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Ly93

Ly93 structure

CAS No.: 1883528-69-5

Chemical Name:: Ly93

Synonyms: Ly93;Ly93,Ly-93;SMS2-IN-Ly93;Benzamide, 2-[(2-ethylphenyl)methoxy]-N-3-pyridinyl-;2-[(2-ethylphenyl)methoxy]-N-(pyridin-3-yl)benzamide

CBNumber:: CB78054633

Molecular Formula:: C21H20N2O2

Molecular Weight:: 332.4

MDL Number:: MFCD32067900

MOL File:: 1883528-69-5.mol

Last updated:2024-07-02 08:55:17

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Ly93 Properties

Boiling point	450.6±35.0 °C(Predicted)
Density	1.191±0.06 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO : 250 mg/mL (752.11 mM; Need ultrasonic)
pka	12.67±0.70(Predicted)
form	Solid
color	Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H319-H335-H315
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P

Ly93 Chemical Properties,Uses,Production

Biological Activity

Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor, with an IC50 of 91 nM[1]. Ly93 (100 mg/kg, i.g. once daily for 7 days) significantly decreases the plasma SM levels of C57BL/6J mice[1].Ly93 dose-dependently attenuates the atherosclerotic lesions in the root and the entire aorta as well as macrophage content in lesions, in apolipoprotein E gene knockout mice[1].

References

[1]. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882.

Ly93 Preparation Products And Raw materials

Raw materials

Preparation Products

Ly93 Suppliers

Global( 14)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	757984502@qq.com	China	892	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9707	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11289	58
Nanjing Shizhou Biology Technology Co.,Ltd	025-85560043 15850508050	info@synzest.com	China	9287	58
ShangHai ChuanQian Chemcial Technique Centre	15869524721	3525679403@qq.com	China	3714	58
Changzhou Furuisi Biotechnology Co., Ltd	0519-85524369	3477467573@qq.com	China	8618	58
Jinan Jiuli Biotechnology Co. , Ltd.	15865264761	486064515@qq.com	China	3113	58
Nanjing Shizhou Biology Technology Co.,Ltd	18351873721	helen.zhang@synzest.com	China	8298	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
Shanghai EFE Biological Technology Co., Ltd.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58
Nanjing Shizhou Biology Technology Co.,Ltd	58
ShangHai ChuanQian Chemcial Technique Centre	58
Changzhou Furuisi Biotechnology Co., Ltd	58
Jinan Jiuli Biotechnology Co. , Ltd.	58
Nanjing Shizhou Biology Technology Co.,Ltd	58

Ly93 SMS2-IN-Ly93 2-[(2-ethylphenyl)methoxy]-N-(pyridin-3-yl)benzamide Ly93,Ly-93 Benzamide, 2-[(2-ethylphenyl)methoxy]-N-3-pyridinyl- 1883528-69-5