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PROTAC KRASG12C Degrader-LC-2

PROTAC KRASG12C Degrader-LC-2 Structure
PROTAC KRASG12C Degrader-LC-2 structure
CAS No.
2502156-03-6
Chemical Name:
PROTAC KRASG12C Degrader-LC-2
Synonyms
LC-2;PROTAC KRASG12C Degrader-LC-2;(2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m;(2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;L-Prolinamide, N-[3-[3-[(2S)-2-[[[7-(8-chloro-1-naphthalenyl)-4-[(3S)-3-(cyanomethyl)-4-(2-fluoro-1-oxo-2-propen-1-yl)-1-piperazinyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl]oxy]methyl]-1-pyrrolidinyl]propoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-
CBNumber:
CB78200421
Molecular Formula:
C59H71ClFN11O7S
Molecular Weight:
1132.78
MDL Number:
MFCD32857122
MOL File:
Mol file
Last updated:2024-07-02 08:55:17
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PROTAC KRASG12C Degrader-LC-2 Properties

Density 1.297±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 50 mg/mL (44.14 mM; ultrasonic and warming and heat to 80°C)
form Solid
pka 14.07±0.40(Predicted)
color Off-white to brown

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

PROTAC KRASG12C Degrader-LC-2 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0139674 LC-2 2502156-03-6 1mg $550 2021-12-16 Buy
ChemScene CS-0139674 LC-2 2502156-03-6 5mg $1500 2021-12-16 Buy
ChemScene CS-0139674 LC-2 2502156-03-6 10mg $2500 2021-12-16 Buy
ChemScene CS-0139674 LC-2 2502156-03-6 25mg $4800 2021-12-16 Buy
CSNpharm CSN27182 LC-2 2502156-03-6 1mg $360 2021-12-16 Buy
Product number Packaging Price Buy
CS-0139674 1mg $550 Buy
CS-0139674 5mg $1500 Buy
CS-0139674 10mg $2500 Buy
CS-0139674 25mg $4800 Buy
CSN27182 1mg $360 Buy

PROTAC KRASG12C Degrader-LC-2 Chemical Properties,Uses,Production

Description

LC-2 is a von Hippel-Lindau-based PROTAC which can degrade endogenous KRAS G12C. It covalently binds KRAS G12C with a MARTX849 warhead and recruits the E3 ligase VHL which degrades the KRAS G12C and suppresses MAPK signaling in homozygous and heterzygous KRAS G12C cell lines.

storage

Store at -20°C

PROTAC KRASG12C Degrader-LC-2 Preparation Products And Raw materials

Raw materials

Preparation Products

PROTAC KRASG12C Degrader-LC-2 Suppliers

Global( 29)Suppliers
Supplier Tel Email Country ProdList Advantage
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525 masar@topule.com China 8467 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139 orders@jknbiochem.com China 5221 58
Bide Pharmatech Ltd. 400-164-7117 13681763483 product02@bidepharm.com China 41462 60
DebyeTec.com Inc. 18086626237 18086626237 sales@debyesci.com China 2645 56
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994 2853530910@QQ.com China 8011 62
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1456 58
DC Chemicals 021-58447131 13564518121 sales@dcchemicals.com China 9409 58
Guangzhou Younan Technology Co., Ltd 020-82000279 18988968278 sales@ubiochem.com China 4297 58
Supplier Advantage
Wuhan Topule Biopharmaceutical Co., Ltd 		58
Jilin Chinese Academy of Sciences-yanshen Technology 		58
Aladdin Scientific 		58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		58
Bide Pharmatech Ltd. 60
DebyeTec.com Inc. 56
ShangHai Biochempartner Co.,Ltd 62
Jilin Province Woda Biotechnology Co., Ltd. 58
DC Chemicals 58
Guangzhou Younan Technology Co., Ltd 58

2502156-03-6(PROTAC KRASG12C Degrader-LC-2)Related Search:

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PROTAC KRASG12C Degrader-LC-2 LC-2 (2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (2S,4R)-1-((S)-2-(3-(3-((S)-2-(((7-(8-Chloronaphthalen-1-yl)-4-((S)-3-(cyanomethyl)-4-(2-fluoroacryloyl)piperazin-1-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)oxy)methyl)pyrrolidin-1-yl)propoxy)propanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-m L-Prolinamide, N-[3-[3-[(2S)-2-[[[7-(8-chloro-1-naphthalenyl)-4-[(3S)-3-(cyanomethyl)-4-(2-fluoro-1-oxo-2-propen-1-yl)-1-piperazinyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl]oxy]methyl]-1-pyrrolidinyl]propoxy]-1-oxopropyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- 2502156-03-6