Dot1L-IN-4
- CAS No.
- 2565705-02-2
- Chemical Name:
- Dot1L-IN-4
- Synonyms
- Dot1L- IN-4;QQN05022(Dot1L-IN-4);H3K79,Histone Methyltransferase,histone,methyltransferase,lysine,DOT1L,Dot1L IN 4,Inhibitor,Dot-1L-IN-4,Dot1LIN4,inhibit;N1-[(3-Chloro-pyridin-2-yl)-(2,2-difluoro-benzo[1,3]dioxol-4-yl)-methyl]-4-methanesulfonyl-N2-(4-methoxy-6-piperazin-1-yl-[1,3,5]triazin-2-yl)-benzene-1,2-diamine;1,2-Benzenediamine, N1-[(S)-(3-chloro-2-pyridinyl)(2,2-difluoro-1,3-benzodioxol-4-yl)methyl]-N2-[4-methoxy-6-(1-piperazinyl)-1,3,5-triazin-2-yl]-4-(methylsulfonyl)-
- CBNumber:
- CB78364259
- Molecular Formula:
- C28H27ClF2N8O5S
- Molecular Weight:
- 661.08
- MDL Number:
- MFCD33023947
- MOL File:
- 2565705-02-2.mol
Dot1L-IN-4 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0109501 | Dot1L-IN-4 99.60% | 2565705-02-2 | 5mg | $580 | 2021-12-16 | Buy |
| ChemScene | CS-0109501 | Dot1L-IN-4 99.60% | 2565705-02-2 | 10mg | $980 | 2021-12-16 | Buy |
| ChemScene | CS-0109501 | Dot1L-IN-4 99.60% | 2565705-02-2 | 25mg | $1900 | 2021-12-16 | Buy |
| ChemScene | CS-0109501 | Dot1L-IN-4 99.60% | 2565705-02-2 | 50mg | $3200 | 2021-12-16 | Buy |
| ChemScene | CS-0109501 | Dot1L-IN-4 99.60% | 2565705-02-2 | 100mg | $5000 | 2021-12-16 | Buy |
Dot1L-IN-4 Chemical Properties,Uses,Production
Biological Activity
Dot1L-IN-4 is a potent disruptor of telomeric silencing 1-like protein (DOT1L) inhibitor with an IC50 SPA DOT1L of 0.11 nM[1]. Dot1L-IN-4 (Compound 10) is tested in cellular assays to assess the ability to inhibit the dimethylation of H3K79 in HeLa cells (ED50 H3K79me2 Elisa=1.7 nM) and HOXA9 gene expression in Molm-13 cells (ED50 HOXA9 RGA=33 nM). Dot1L-IN-4 also inhibits mixed lineage leukemia (MLL) with an IC50 of 99 μM[1]. Dot1L-IN-4 (Compound 10; 300 mg/kg; p.o.; qd) is not tolerated at such a high dose by tumor xenograft bearing mice, and at a 6-fold reduced dose, the tumor growth as well as the HOXA9 reporter gene mRNA are reduced only by less than half as compared to control animals[1].
References
[1]. Frédéric Stauffer, et al. New Potent DOT1L Inhibitors for in Vivo Evaluation in Mouse. ACS Med. Chem. Lett. 2019, 10, 12, 1655-1660.
Dot1L-IN-4 Preparation Products And Raw materials
Raw materials
Preparation Products
Dot1L-IN-4 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Wuhan Acumen Bio-Technology Co.,ltd | 027-027-16602739303 16602739303 | 673003916@qq.com | China | 2997 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4197 | 55 | |
| Shanghai JingRon Chemical Technology Co., Ltd. | 021-60546673 13701861782 | kuanga111@sina.com | China | 821 | 58 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8018 | 62 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2988 | 58 |
| Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9863 | 58 |