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Docetaxel

Docetaxel Structure
Docetaxel structure
CAS No.
125354-16-7
Chemical Name:
Docetaxel
Synonyms
CS-878;DOCETAXOL;Docetaxal;PNU 101383;10-Acetyltaxotere;MK-0431 phosphate;10-Acetyldocetaxel;Docetaxel impurity G;ACETYLDOCETAXEL, 10-;Paclitaxel Impurity 3
CBNumber:
CB7842087
Molecular Formula:
C45H55NO15
Molecular Weight:
849.93
MDL Number:
MFCD09028033
MOL File:
125354-16-7.mol
Last updated:2024-11-07 08:52:35
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Docetaxel Properties

Melting point 201-203 °C(Solv: methanol (67-56-1))
Boiling point 901.4±65.0 °C(Predicted)
Density 1.36±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form Solid
pka 11.20±0.46(Predicted)
color White to Off-White

Docetaxel price More Price(16)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC D494565 Docetaxal 125354-16-7 100mg $120 2021-12-16 Buy
TRC D494565 Docetaxal 125354-16-7 1g $580 2021-12-16 Buy
Usbiological 163942 Docetaxal 125354-16-7 5mg $460 2021-12-16 Buy
American Custom Chemicals Corporation API0010442 10-ACETYLDOCETAXEL 95.00% 125354-16-7 10MG $477.75 2021-12-16 Buy
Biosynth Carbosynth FA46386 10-Acetyl docetaxel 125354-16-7 50mg $1800 2021-12-16 Buy
Product number Packaging Price Buy
D494565 100mg $120 Buy
D494565 1g $580 Buy
163942 5mg $460 Buy
API0010442 10MG $477.75 Buy
FA46386 50mg $1800 Buy

Docetaxel Chemical Properties,Uses,Production

Uses

Docetaxal (Docetaxel EP Impurity G) is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de-polymerization to free tubulin.

Uses

Docetaxal is an impurity of Docetaxel (D494420), a semisynthetic derivative of Paclitaxel (P132500). Docetaxel is an antimitotic agent that promotes the assembly of micro-tubules and inhibits their de -polymerization to free tubulin.

General Description

Docetaxel is available in single-dose vials of 20 mg/0.5 mLand 80 mg/2 mL for IV administration in the treatment of breast, NSCLC, and prostate cancers. It has also been utilizedin non–FDA-approved treatment of head, neck, gastric,bladder, and refractory ovarian cancers.
Docetaxel is highly plasma protein bound (80%) andwidely distributed with the highest concentration in the hepatobiliarysystem, but it does not appear to cross the bloodbrainbarrier. The metabolism of docetaxel has been lesswell studied than that of paclitaxel. The use of human livermicrosomes has indicated that metabolism involves oxidationof one of the tert-butyl methyl groups of the C-13 sidechain to initially give the alcohol. Further oxidation to thealdehyde and carboxylic acid both of which may cyclizewith the carbamate nitrogen to give stereoisomeric hydroxyoxazolidinonesand an oxazolidinedione, respectively. Noactive metabolites have been identified. The major enzymeinvolved is CYP3A4. The drug is primarily eliminated in thefeces with a terminal half-life of 11 hours.
The adverse effects profile for docetaxel is similar to thatof paclitaxel but also includes reversible fluid retention that isdose related. This has been associated with an initial increasein capillary permeability followed by a decrease in lymphaticdrainage later in the therapy. Restriction of sodium intake andpretreatment with corticosteroids is usually successful inminimizing this adverse effect. Peripheral neuropathy is seenwith docetaxel but occurs less often than with paclitaxel.Fatigue and muscle pain are commonly seen, and fever mayoccur in up to 30% of patients who are infection free.

Docetaxel Preparation Products And Raw materials

Raw materials

Preparation Products

Docetaxel Suppliers

Global( 204)Suppliers
Supplier Tel Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512 info@tianfuchem.com China 21634 55
Nanjing ChemLin Chemical Industry Co., Ltd. 		025-83697070 product@chemlin.com.cn CHINA 3009 60
Nanjing Finetech Chemical Co., Ltd. 		025-85710122 17714198479 sales@fine-chemtech.com CHINA 885 55
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29884 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715 admin@nexconn.com China 10310 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD 		86-13657291602 linda@hubeijusheng.com CHINA 22963 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39894 58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD 		+8615377521700 wangwendy93@gmail.com China 868 58
Supplier Advantage
Henan Tianfu Chemical Co.,Ltd. 		55
Nanjing ChemLin Chemical Industry Co., Ltd. 		60
Nanjing Finetech Chemical Co., Ltd. 		55
career henan chemical co 		58
Shenzhen Nexconn Pharmatechs Ltd 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hubei xin bonus chemical co. LTD 		58
Standardpharm Co. Ltd. 		58
Chongqing Chemdad Co., Ltd 		58
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD 		58

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View Lastest Price from Docetaxel manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Docetaxal pictures 2024-11-07 Docetaxal
125354-16-7
 US $40.00-113.00 / mg 10g TargetMol Chemicals Inc.
Docetaxel pictures 2024-03-16 Docetaxel
125354-16-7
 US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Docetaxel USP/EP/BP pictures 2021-07-03 Docetaxel USP/EP/BP
125354-16-7
 US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
  • Docetaxal pictures
  • Docetaxal
    125354-16-7
  • US $40.00-113.00 / mg
  • TargetMol Chemicals Inc.
  • Docetaxel pictures
  • Docetaxel
    125354-16-7
  • US $0.00 / KG
  • 98%+
  • WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD

125354-16-7(Docetaxel)Related Search:

Docetaxel Paclitaxel tert-Butanol tert-Butyl peroxyacetate tert-Butyl acetate
DOCETAXEL HYDRATE,Docetaxel trihydrate (2R,3S)-2-HYDROXY-3-(N-TERTBUTOXYCARBONYL) AMINO-3- PHENYL- METHYL PROPIONATE (INTERMEDIATE OF DOCETAXEL) SIDE CHAINS OF DOCETAXEL--4 SIDE CHAINS OF DOCETAXEL--1 SIDE CHAINS OF DOCETAXEL--3
10-Oxo Docetaxel 13-O-(Triethylsilyl) Baccatin III 2-Debenzoyl-2-pentenoyl Docetaxel Docetaxel Impurity 5 Docetaxel impurity 1/(2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-6,9,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-4-(((2,2,2-trichloroethoxy)carbonyl)oxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl
Docetaxel Impurity 36 (2S,3S)-methyl 3-(tert-butoxycarbonylamino)-2-hydroxy-3-phenylpropanoate Docetaxel Impurity 15

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10-Acetyldocetaxel 10-Acetyltaxotere Docetaxal PNU 101383 ACETYLDOCETAXEL, 10-(P) Docetaxel N-Debenzoyl-N-(tert-butoxycarbonyl)taxol DOCETAXOL N-Debenzoyl-N-(tert-butoxycarbonyl)taxol Docetaxel impurity G Docetaxel Impurity 7(Docetaxel EP Impurity G) Docetaxel EP Impurity G CS-878 Paclitaxel Impurity 3 Docetaxel EP Impurity G (10-Acetyl Docetaxel) Docetaxel impurity 7/Docetaxel EP Impurity G/10-Acetyl Docetaxel/(αR,βS)-β-[[(1,1-Dimethylethoxy)carbonyl]amino]-α-hydroxybenzenepropanoic Acid (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-Bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dode Benzenepropanoic acid, β-[[(1,1-dimethylethoxy)carbonyl]amino]-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,... (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxete-6,12b-diyldiacetate Docetaxel,125354-16-7 MK-0431 phosphate 5β,20-epoxy-1,7β-dihydroxy-9-oxotax-11-ene-2α,4,10β,13α-tetrayl 4,10-diacetate 2-benzoate 13-[(2R,3S)-3-[[(1,1-dimethylethoxy)carbonyl]amino]-2-hydroxy-3-phenylpropanoate] (10-acetyldocetaxel). Docetaxel EP Impurity G（Paclitaxel Impurity 3） ACETYLDOCETAXEL, 10- (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12-(benzoyloxy)-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12 125354-16-7 C45H55NO15