p-Toluic acid
- CAS No.
- 99-94-5
- Chemical Name:
- p-Toluic acid
- Synonyms
- 4-METHYLBENZOIC ACID;PTLA;p-Tolylcarboxylic acid;4-TOLUIC ACID;para-Toluic acid;BENZOIC ACID, 4-METHYL-;p-toluic;P-TOLUYLIC ACID;p-carboxytoluene;P-METHYLBENZOIC ACID
- CBNumber:
- CB7854776
- Molecular Formula:
- C8H8O2
- Molecular Weight:
- 136.15
- MDL Number:
- MFCD00002565
- MOL File:
- 99-94-5.mol
- MSDS File:
- SDS
| Melting point | 177-180 °C (lit.) |
|---|---|
| Boiling point | 274-275 °C (lit.) |
| Density | 1,06 g/cm3 |
| bulk density | 700kg/m3 |
| vapor pressure | 0.02 hPa (70 °C) |
| refractive index | 1.5120 (estimate) |
| Flash point | 181°C |
| storage temp. | Store below +30°C. |
| solubility | 0.3g/l |
| pka | 4.36(at 25℃) |
| form | Powder |
| color | White to slightly yellow-cream |
| PH | 3.73(1 mM solution);3.2(10 mM solution);2.69(100 mM solution) |
| Water Solubility | <0.1 g/100 mL at 19 ºC |
| Merck | 14,9535 |
| BRN | 507600 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChIKey | LPNBBFKOUUSUDB-UHFFFAOYSA-N |
| LogP | 2.44 |
| CAS DataBase Reference | 99-94-5(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | A26GBX5SSV |
| NIST Chemistry Reference | Benzoic acid, 4-methyl-(99-94-5) |
| EPA Substance Registry System | Benzoic acid, 4-methyl- (99-94-5) |
| UNSPSC Code | 12352106 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P362+P364 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| Safety Statements | 22-24/25 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | XU1575000 | |||||||||
| Autoignition Temperature | 570 °C | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29163900 | |||||||||
| Toxicity | LD50 orally in Rabbit: 400 mg/kg | |||||||||
| NFPA 704 |
|
p-Toluic acid price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | T36803 | p-Toluic acid 98% | 99-94-5 | 5g | $36.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 41768 | p-Toluic acid analytical standard | 99-94-5 | 100mg | $89.2 | 2022-05-15 | Buy |
| TCI Chemical | T0293 | p-Toluic Acid >98.0%(GC)(T) | 99-94-5 | 25g | $20 | 2024-03-01 | Buy |
| TCI Chemical | T0293 | p-Toluic Acid >98.0%(GC)(T) | 99-94-5 | 500g | $61 | 2024-03-01 | Buy |
| Alfa Aesar | A11506 | p-Toluic acid, 98% | 99-94-5 | 250g | $49.4 | 2024-03-01 | Buy |
p-Toluic acid Chemical Properties,Uses,Production
Uses
p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.
Chemical Properties
colourless crystals or white crystalline powder. Slightly soluble in water; soluble in alcohol and ether. Combustible.
Uses
Intermediates of Liquid Crystals
Uses
p-Toluic Acid is used as a reagent in the synthesis of several organic compounds including that of 2-aryl-1,3,4-oxadiazole derivatives which are potential antibacterial agents. Also used in the synthesis of 4-(bromomethyl) benzoic acid.
Definition
ChEBI: A methylbenzoic acid in which the methyl substituent is located at position 4.
Synthesis Reference(s)
Journal of the American Chemical Society, 94, p. 4024, 1972 DOI: 10.1021/ja00766a069
The Journal of Organic Chemistry, 37, p. 2564, 1972 DOI: 10.1021/jo00981a010
Air & Water Reactions
Fine dust dispensed in air in sufficient concentrations, and in the presence of an ignition source is a potential dust explosion hazard. . Insoluble in water.
Reactivity Profile
p-Toluic acid is a carboxylic acid. Carboxylic acids donate hydrogen ions if a base is present to accept them. They react in this way with all bases, both organic (for example, the amines) and inorganic. Their reactions with bases, called "neutralizations", are accompanied by the evolution of substantial amounts of heat. Neutralization between an acid and a base produces water plus a salt. Carboxylic acids with six or fewer carbon atoms are freely or moderately soluble in water; those with more than six carbons are slightly soluble in water. Soluble carboxylic acid dissociate to an extent in water to yield hydrogen ions. The pH of solutions of carboxylic acids is therefore less than 7.0. Many insoluble carboxylic acids react rapidly with aqueous solutions containing a chemical base and dissolve as the neutralization generates a soluble salt. Carboxylic acids in aqueous solution and liquid or molten carboxylic acids can react with active metals to form gaseous hydrogen and a metal salt. Such reactions occur in principle for solid carboxylic acids as well, but are slow if the solid acid remains dry. Even "insoluble" carboxylic acids may absorb enough water from the air and dissolve sufficiently in p-Toluic acid to corrode or dissolve iron, steel, and aluminum parts and containers. Carboxylic acids, like other acids, react with cyanide salts to generate gaseous hydrogen cyanide. The reaction is slower for dry, solid carboxylic acids. Insoluble carboxylic acids react with solutions of cyanides to cause the release of gaseous hydrogen cyanide. Flammable and/or toxic gases and heat are generated by the reaction of carboxylic acids with diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides. Carboxylic acids, especially in aqueous solution, also react with sulfites, nitrites, thiosulfates (to give H2S and SO3), dithionites (SO2), to generate flammable and/or toxic gases and heat. Their reaction with carbonates and bicarbonates generates a harmless gas (carbon dioxide) but still heat. Like other organic compounds, carboxylic acids can be oxidized by strong oxidizing agents and reduced by strong reducing agents. These reactions generate heat. A wide variety of products is possible. Like other acids, carboxylic acids may initiate polymerization reactions; like other acids, they often catalyze (increase the rate of) chemical reactions. p-Toluic acid is incompatible with strong oxidizers. p-Toluic acid is also incompatible with strong bases. .
Fire Hazard
Flash point data for p-Toluic acid are not available; however, p-Toluic acid is probably combustible.
Flammability and Explosibility
Not classified
Purification Methods
Crystallise the acid from water, water/EtOH (1:1), MeOH/water or *benzene. [Beilstein 9 IV 1724.] Aromatic acid impurities (to <0.05%) can be removed via the (±)--methylbenzylamine salt as described for 2,4-dichlorobenzoic acid [Ley & Yates Organic Process Research & Development 12 120 2008]. The S-benzylisothiuronium salt has m 164o (from aqueous EtOH).
p-Toluic acid Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of4
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Dalian Richfortune Chemicals Co., Ltd | 0411-84820922 8613904096939 | sales@richfortunechem.com | China | 304 | 57 |
| Anhui Royal Chemical Co., Ltd. | +86-25-86655873 +8613962173137 | marketing@royal-chem.com | China | 193 | 55 |
| Ningxia Jinhua Chemical Co.,Ltd | 025-52279164 | info@nxjhchem.com | China | 79 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| Hebei Weibang Biotechnology Co., Ltd | +8615531157085 | abby@weibangbio.com | China | 8804 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5887 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 997 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615350851019 | admin@86-ss.com | China | 1001 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29792 | 60 |
Related articles
- The Essential Role of p-Toluic Acid in Chemical Industry: Properties, Applications, and Safe Handling
- p-Toluic acid, also known as 4-methylbenzoic acid, is a significant compound in the field of organic chemistry.
- Aug 30，2024
View Lastest Price from p-Toluic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2025-02-14 | p-Toluic Acid
99-94-5
|
US $200.00-95.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2025-02-14 | p-Toluic acid
99-94-5
|
US $0.00 / Kg/Drum | 1KG | 99% | 1000tons | Hebei Mujin Biotechnology Co.,Ltd | |
 |
2025-02-13 | p-Toluic acid
99-94-5
|
US $99.00-66.00 / kg | 0.0010000000474974513kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD |
-
- p-Toluic Acid
99-94-5
- US $200.00-95.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- p-Toluic acid
99-94-5
- US $0.00 / Kg/Drum
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- p-Toluic acid
99-94-5
- US $99.00-66.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD