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IL-4 Inhibitor

IL-4 Inhibitor Structure
IL-4 Inhibitor structure
CAS No.
1332184-63-0
Chemical Name:
IL-4 Inhibitor
Synonyms
IL-4 Inhibitor;IL-4-inhibitor-1;IL4inhibitor1,IL 4 inhibitor 1;2-Amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile;2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-3-pyridinecarbonitrile;3-Pyridinecarbonitrile, 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-
CBNumber:
CB78571042
Molecular Formula:
C18H12FN3O2
Molecular Weight:
321.31
MDL Number:
MFCD20240733
MOL File:
1332184-63-0.mol
Last updated:2024-11-19 20:33:22
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IL-4 Inhibitor Properties

Boiling point 590.6±50.0 °C(Predicted)
Density 1.50±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:5): 0.1 mg/ml,Ethanol: 10 mg/ml
form A crystalline solid
pka 7.28±0.20(Predicted)
color Light yellow to yellow

IL-4 Inhibitor Chemical Properties,Uses,Production

Biological Activity

IL-4 inhibitor is an inhibitor of IL-4.1 It binds to IL-4 with a Kd value of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50 = 1.81 μM). It is selective for IL-4 over IL-13 (EC50 = 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50 = 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.

References

1.Quinnell, S.P., Leifer, B.S., Nestor, S.T., et al.A small-molecule inhibitor to the cytokine interleukin-4ACS Chem. Biol.15(10)2649-2654(2020)

IL-4 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

IL-4 Inhibitor Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52925 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai SuperLan Chemcial Technique Centre 021-2022843681 15618226720 lucy@atkchemical.com China 10267 58
Jinan Jiuli Biotechnology Co. , Ltd. 15865264761 486064515@qq.com China 3732 58
ChemeGen 中国 18818260767 2625930290@qq.com China 6973 58
Bide Pharmatech Ltd. 400-1647117 13681763483 product02@bidepharm.com China 62163 58
Beijing Biocreative Technology Co., Ltd. 15522676233 3007606172@qq.com China 1248 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Suzhou Zhixin Biotechnology Co., Ltd. 0512-65118909 15162312715 sales@szzxbio.com China 2990 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Aladdin Scientific 		58
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai SuperLan Chemcial Technique Centre 58
Jinan Jiuli Biotechnology Co. , Ltd. 58
ChemeGen 中国 58
Bide Pharmatech Ltd. 58
Beijing Biocreative Technology Co., Ltd. 58
TargetMol Chemicals Inc. 58
Suzhou Zhixin Biotechnology Co., Ltd. 58

View Lastest Price from IL-4 Inhibitor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IL-4-inhibitor-1 pictures 2024-11-19 IL-4-inhibitor-1
1332184-63-0
 US $39.00-347.00 / mg 98.26% 10g TargetMol Chemicals Inc.
  • IL-4-inhibitor-1 pictures
  • IL-4-inhibitor-1
    1332184-63-0
  • US $39.00-347.00 / mg
  • 98.26%
  • TargetMol Chemicals Inc.
IL-4 Inhibitor IL-4-inhibitor-1 IL4inhibitor1,IL 4 inhibitor 1 3-Pyridinecarbonitrile, 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)- 2-amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)-3-pyridinecarbonitrile 2-Amino-4-(3,4-dihydroxyphenyl)-6-(4-fluorophenyl)nicotinonitrile 1332184-63-0