Isosorbide-2-Acetate
- CAS No.
- 13042-39-2
- Chemical Name:
- Isosorbide-2-Acetate
- Synonyms
- 2-Acetyl-isosorbide;Isosorbide Impurity 5;Isosorbide Impurity 15;Isosorbide Dinitrate Impurity 5;1,4:3,6-dianhydro-D-glucitol 2-acetate;1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol;D-Glucitol, 1,4:3,6-dianhydro-, 2-acetate;(3S,3aR,6R,6aR)-6-hydroxyhexahydrofuro[3,2-b]furan-3-yl acetate;(6-Hydroxy-2,3,3a,5,6,6a-hexahydrofuro[2,3-d]furan-3-yl) acetate;(6-hydroxy-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-3-yl) acetate
- CBNumber:
- CB7874929
- Molecular Formula:
- C8H12O5
- Molecular Weight:
- 188.18
- MDL Number:
- MFCD09264290
- MOL File:
- 13042-39-2.mol
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Isosorbide-2-Acetate price More Price(8)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Usbiological | 293150 | 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol | 13042-39-2 | 10g | $359 | 2021-12-16 | Buy |
Biosynth Carbosynth | MD09909 | 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol | 13042-39-2 | 100g | $500 | 2021-12-16 | Buy |
American Custom Chemicals Corporation | CHM0077644 | ISOSORBIDE-2-ACETATE 95.00% | 13042-39-2 | 5G | $909.56 | 2021-12-16 | Buy |
Biosynth Carbosynth | MD09909 | 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol | 13042-39-2 | 5G | $50 | 2021-12-16 | Buy |
Biosynth Carbosynth | MD09909 | 1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol | 13042-39-2 | 10g | $80 | 2021-12-16 | Buy |
Isosorbide-2-Acetate Chemical Properties,Uses,Production
Chemical Properties
Isosorbide-2-acetate is a colourless, crystalline substance with a melting point of 75°-76°C. It has a TLC (diethyl ether) value of Rf=0.28 and a specific rotation of [α]D 20 =+77.1° (c=1.12, ethyl acetate). It is an important intermediate in the synthesis of isosorbide-5-mononitrate, a well-known organic nitrate drug.
Uses
1,4:3,6-Dianhydro-2-O-acetyl-D-glucitol is a useful reagent in the practical enzymic synthesis of isosorbide-2-acetate.
Preparation
The synthesis of isosorbide-2-acetate involves dissolving 2.30 g (10 mmol) of isosorbide-2,5-diacetate in 15 ml of acetone and 5 ml of n-heptanol. Then, 200 mg of lipase from Pseudomonas fluorescens (SAM II, Amano Pharmaceuticals) is added, and the mixture is stirred at room temperature for 2 days. After that, the enzyme is removed by filtration, and the resulting solid is washed thoroughly with acetone. The solvent, excess n-heptanol, and heptyl acetate residue are removed by distillation.
The yield is 1.71 g (9.09 mmol) of isosorbide-2-acetate, which is a colourless crystalline substance with a melting point of 75°-76°C. The overall yield is 91%.
US5538891A
Isosorbide-2-Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | sales@myuchem.com | China | 7192 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52861 | 58 |
CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
Jiangsu Nata Opto-electronic Material Co.,Ltd. | +86-0512-62520998 +86-15030927757 | gaoym@natachem.com | China | 229 | 58 |
PT CHEM GROUP LIMITED | peter68@ptchemgroup.com | China | 35426 | 58 |
View Lastest Price from Isosorbide-2-Acetate manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2023-05-25 | Isosorbide-2-Acetate
13042-39-2
|
US $0.00 / g | 50g | 98% | 5kg | Jiangsu Nata Opto-electronic Material Co.,Ltd. |
- Isosorbide-2-Acetate
13042-39-2
- US $0.00 / g
- 98%
- Jiangsu Nata Opto-electronic Material Co.,Ltd.