Parecoxib sodium
- CAS No.
- Chemical Name:
- Parecoxib sodium
- Synonyms
- CBNumber:
- CB7952276
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| Melting point | 272-275°C |
|---|---|
| storage temp. | Hygroscopic, Refrigerator, under inert atmosphere |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Water (Slightly) |
| form | Solid |
| color | White |
| FDA UNII | EB87433V6F |
| NCI Drug Dictionary | parecoxib sodium |
Parecoxib sodium price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 462056 | Parecoxib Sodium | 10mg | $475 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb134808 | PARECOXIB SODIUM >99% | 250mg | $615.4 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb134808 | PARECOXIB SODIUM >99% | 1g | $1208.7 | 2021-12-16 | Buy | |
| Biorbyt Ltd | orb134808 | PARECOXIB SODIUM >99% | 100mg | $414.8 | 2021-12-16 | Buy |
Parecoxib sodium Chemical Properties,Uses,Production
Description
Parecoxib sodium (19) is a cyclooxygenase 2 (COX-2) inhibitor and was introduced by Pharmacia (now Pfizer) as an injectable formulation for short-term treatment of postoperative pain. Parecoxib is a water-soluble prodrug of valdecoxib (27) that undergoes biotransformation in vivo to release valdecoxib (27).
Uses
Anti-inflammatory; analgesic (cyclooxygenase).
Synthesis
The synthesis of parecoxib sodium (19) started from commercially available deoxybenzoin (165). Deoxybenzoin (165) was treated with hydroxylamine in EtOH/H2O (3:1) to give deoxybenzoin oxime 166 in 95% yield. Deprotonation of oxime 166 with two equivalents of n-hexyllithium followed by condensation with ethyl acetate afforded isoxazoline 167 in 59% yield. Treatment of isoxazoline 167 with chlorosulfonic acid followed by reaction of the incipient sulfonyl chloride with aqueous ammonia furnished valdecoxib (27). Acylation of isoxazole sulfonamide 27 with propionic anhydride afforded parecoxib, which was converted to its sodium salt by titration with aqueous sodium hydroxide (64%).
Parecoxib sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Parecoxib sodium Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | info@afinechem.com | China | 15395 | 58 |
| Supplier | Advantage |
|---|---|
| AFINE CHEMICALS LIMITED | 58 |