10-Hydroxy-2-decenoic acid
- CAS No.
- 14113-05-4
- Chemical Name:
- 10-Hydroxy-2-decenoic acid
- Synonyms
- 10-HAD;10-HDA;10H2DA;jelly acid;Queenbeeaci;QUEEN BEE ACID;Queen been acid;ROYAL JELLY ACID;hydroxy-decenouc acid;10-HYDROXYDECENOIC ACID
- CBNumber:
- CB8109967
- Molecular Formula:
- C10H18O3
- Molecular Weight:
- 186.25
- MDL Number:
- MFCD00204506
- MOL File:
- 14113-05-4.mol
| Melting point | 64.0 to 68.0 °C |
|---|---|
| Boiling point | 339.2±15.0 °C(Predicted) |
| Density | 1.038±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml |
| form | powder to crystal |
| pka | 4.78±0.10(Predicted) |
| color | White to Almost white |
| LogP | 1.808 (est) |
| CAS DataBase Reference | 14113-05-4(CAS DataBase Reference) |
| FDA UNII | 76B519G7TJ |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 | |||||||||
| Safety Statements | 24/25 | |||||||||
| HS Code | 29181990 | |||||||||
| NFPA 704 |
|
10-Hydroxy-2-decenoic acid price More Price(27)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML3381 | 10-Hydroxy-trans-2-decenoic acid ≥98% (HPLC) | 14113-05-4 | 10MG | $86.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML3381 | 10-Hydroxy-trans-2-decenoic acid ≥98% (HPLC) | 14113-05-4 | 50MG | $350 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL89223 | 10-Hydroxy-trans-2-decenoic acid phyproof? Reference Substance | 14113-05-4 | 10mg | $608 | 2024-03-01 | Buy |
| TCI Chemical | H1337 | trans-10-Hydroxy-2-decenoic Acid >97.0%(GC)(T) | 14113-05-4 | 200mg | $72 | 2024-03-01 | Buy |
| TCI Chemical | H1337 | trans-10-Hydroxy-2-decenoic Acid >97.0%(GC)(T) | 14113-05-4 | 1g | $252 | 2024-03-01 | Buy |
10-Hydroxy-2-decenoic acid Chemical Properties,Uses,Production
Description
10-
Uses
10-Hydroxy-2-decenoic acid has antiseptic, anti-inflammatory, anti-obesity, anti-aging, preventing bone loss and anti-tumour pharmacological effects, with potential therapeutic effects for postmenopausal osteoporosis, as well as benefiting the human gastrointestinal tract[1-3].
Definition
ChEBI: (E)-10-hydroxydec-2-enoic acid is an omega-hydroxy amino acid that is 2-decenoic acid in which one of the hydrogens attached to the terminal carbon is replaced by a hydroxy group and in which the C=C double bond has E configuration. It is a component of royal jelly. It has a role as an animal metabolite and a geroprotector. It is an alpha,beta-unsaturated monocarboxylic acid, a straight-chain fatty acid, a hydroxy monounsaturated fatty acid and an omega-hydroxy-medium-chain fatty acid.
Biological Activity
10-Hydroxy-2-decenoic acid is an orally available royal jelly component that potently inhibits osteoclastogenesis. It binds to free fatty acid receptor 4 (FFAR4) on osteoclasts which inhibits RANKL (receptor activator of nuclear factor-κB (NF-κB) ligand), thereby attenuating the induction of nuclear factor of activated T cells (NFAT) c1. 10-Hydroxy-2-decenoic acid inhibits bone resorption in ovariectomized mice.
The production of pro-inflammatory cytokines, Interleukin (IL)-8, IL-1β and tumor necrosis factor-alpha (TNF-α) in WiDr cells was modulated by 10-HDA. IL-8 were dramatically declined by 10-HDA at 3 mM, while IL-1β and TNF-α were significantly decreased. 10-HDA increased IL-1ra in a dose manner. NF-κB pathway is primarily in response to prototypical pro-inflammatory cytokines, and NF-κB was reduced after 10-HDA treatment. 10-HDA acted as potent bactericide against animal- or human-specific pathogens, including Staphylococcus aureus, Streptococcus alactolyticus, Staphylococcus intermedius B, Staphylococcus xylosus, Salmonella cholearasuis, Vibro parahaemolyticus and Escherichia coli (hemolytic)[1].
References
[1] YUAN-CHANG YANG. 10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells.[J]. BMC Complementary and Alternative Medicine, 2018: 202. DOI:10.1186/s12906-018-2267-9.
[2] YOKO HONDA. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling.[J]. Journal of Aging Research, 2015, 2015: 425261. DOI:10.1155/2015/425261.
[3] YOSUKE TSUCHIYA. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4.[J]. The Journal of Biological Chemistry, 2020, 295 34: 12224-12232. DOI:10.1074/jbc.RA120.013821.
10-Hydroxy-2-decenoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 | sales@hbmojin.com | China | 12840 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5893 | 58 |
| SHANDONG OUCHEM CO.,LTD. | +86-18506360988 +86-18506360988 | wtaili@ouchem.cn | China | 51 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-18034520335 | admin@hbsaisier.cn | China | 1015 | 58 |
| Hebei Longbang Technology Co., LTD | +86-18633929156 +86-18633929156 | admin@hblongbang.com | China | 941 | 58 |
| HebeiShuoshengImportandExportco.,Ltd | +86-18532138899 +86-18532138899 | L18532138899@163.com | China | 939 | 58 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 18779 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Hangzhou FandaChem Co.,Ltd. | +8615858145714 | FandaChem@Gmail.com | China | 9214 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
View Lastest Price from 10-Hydroxy-2-decenoic acid manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-22 | 10-Hydroxy-2-decenoic acid
14113-05-4
|
US $6.00 / kg | 1kg | 99% | 2000KG/Month | HebeiShuoshengImportandExportco.,Ltd | |
 |
2024-11-20 | 10-Hydroxy-2-decenoic acid
14113-05-4
|
US $6.00 / kg | 1kg | More than 99% | 2000KG/Month | Hebei Longbang Technology Co., Ltd | |
 |
2024-11-19 | Royal Jelly acid
14113-05-4
|
US $148.00-62.00 / mg | 98.02% | 10g | TargetMol Chemicals Inc. |
-
- 10-Hydroxy-2-decenoic acid
14113-05-4
- US $6.00 / kg
- 99%
- HebeiShuoshengImportandExportco.,Ltd
-
- 10-Hydroxy-2-decenoic acid
14113-05-4
- US $6.00 / kg
- More than 99%
- Hebei Longbang Technology Co., Ltd
-
- Royal Jelly acid
14113-05-4
- US $148.00-62.00 / mg
- 98.02%
- TargetMol Chemicals Inc.