Bucromarone
- CAS No.
- 78371-66-1
- Chemical Name:
- Bucromarone
- Synonyms
- Bucromarone;2-[4-[3-(Dibutylamino)propoxy]-3,5-dimethylbenzoyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-[4-[3-(dibutylamino)propoxy]-3,5-dimethylbenzoyl]-
- CBNumber:
- CB81117224
- Molecular Formula:
- C29H37NO4
- Molecular Weight:
- 463.61
- MDL Number:
- MFCD00864709
- MOL File:
- 78371-66-1.mol
| FDA UNII | JI688O846T |
|---|
Bucromarone Chemical Properties,Uses,Production
Originator
Bucromarone,Transphyto
Uses
Cardiac depressant (anti-arrhythmic).
Uses
Bucromarone is an antiarrhythmic drug.
Definition
ChEBI: Bucromarone is an aromatic ketone.
Manufacturing Process
1.2 mol of an electrophilic catalyst, advantageously aluminum chloride, was
slowly added to a solution of 48.8 g (0.4 mol) of 2,6-dimethyl phenol in 400
ml of dichloroethane and agitated at room temperature for an hour. The
mixture was cooled to 0°C and a solution of 84.0 g (0.4 mol) of 2-carboxylic
chromone acid chloride in 400 ml of a dichloroethane, was slowly added.
Agitation was continued at 0°C for 5 h and then at room temperature for 4
days. The reaction mixture was poured into 1.6 L of iced 50% hydrochloric
acid. The resulting precipitate was filtered, washed with water, dried and
106.0 g (72% yield) of 2-(3,5-dimethyl-4-hydroxybenzoyl)chromone, melting
point 216°C (recrystallised from dioxane) were obtained.
6.9 g (0.05 mol) of potassium carbonate was added to a solution of 29.4 g
(0.1 mol) of 2-(3,5-dimethyl-4-hydroxybenzoyl)chromone in 250 ml of
dimethyl formamide and kept at 100°C for an hour. A solution of 20.5 g (0.1
mol) of 3-N,N-dibutylamino-1-chloropropane in 100 ml of diethyl formamide
was then added and the resulting solution heated to 130°C for 3 h. The
solution was filtered, the dimethyl formamide was concentrated, dissolved in
300 ml water and extracted twice with 200 ml of benzene. The organic phase
was dried on magnesium sulfate and the hydrochloride was precipitated by
adding hydrochloric ether. 40.0 g (yield 80%) of 2-[4-(3-N,N-dibutylaminopropoxy)-
3,5-dimethylbenzoyl]chromone were obtained (recrystallised from an
acetone/ether mixture).
Therapeutic Function
Antiarrhythmic, Coronary vasodilator
Bucromarone Preparation Products And Raw materials
Raw materials
Preparation Products
Bucromarone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | -- | sales@clearsynth.com | India | 6257 | 58 |
| United States Biological | -- | chemicals@usbio.net | United States | 6214 | 80 |
| Leancare Ltd. | -- | enquiry@leancare.co.uk | United Kingdom | 6446 | 42 |
| Lanospharma Laboratories Co.,Ltd | -- | sales@lanospharma.com | China | 6329 | 56 |
| 2A PharmaChem USA | -- | sales@2apharmachem.com | United States | 6137 | 39 |
| 3B Scientific Corporation | -- | sales@3bsc.com | United States | 6718 | 47 |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| United States Biological | 80 |
| Leancare Ltd. | 42 |
| Lanospharma Laboratories Co.,Ltd | 56 |
| 2A PharmaChem USA | 39 |
| 3B Scientific Corporation | 47 |