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ChemicalBook >> CAS DataBase List >>6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]-

6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]-

6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]- Structure
6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]- structure
CAS No.
2694871-86-6
Chemical Name:
6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]-
Synonyms
BLK-IN-2;6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]-
CBNumber:
CB811235448
Molecular Formula:
C39H41N9O3
Molecular Weight:
683.8
MDL Number:
MOL File:
2694871-86-6.mol
Last updated:2025-04-18 09:52:47
Request For Quotation

6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]- Properties

Density 1.329±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 125 mg/mL (182.80 mM; Need ultrasonic)
form Solid
pka 11.44±0.70(Predicted)
color Light yellow to yellow

6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]- Chemical Properties,Uses,Production

Uses

BLK-IN-2 (compound 25) is a potent and selective irreversible inhibitor of B-Lymphoid tyrosine kinase (BLK), with an IC50 of 5.9 nM. BLK-IN-2 also inhibits BTK (IC50=202.0 nM). BLK-IN-2 shows potent antiproliferative activities against several lymphoma cells[1].

References

[1] Fu T, et, al. Discovery of selective irreversible inhibitors of B-Lymphoid tyrosine kinase (BLK). Eur J Med Chem. 2022 Feb 5;229:114051. DOI:10.1016/j.ejmech.2021.114051

6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]- Suppliers

Global( 1)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
Supplier Advantage
Aladdin Scientific 		58
6-Isoquinolinecarboxamide, N-[3-[[[2-[[3-[[1-[4-(dimethylamino)-1-oxo-2-buten-1-yl]-4-piperidinyl]amino]phenyl]amino]-5-pyrimidinyl]amino]carbonyl]-4-methylphenyl]- BLK-IN-2 2694871-86-6 C39H41N9O3