Atipamezole hydrochloride
- CAS No.
- 104075-48-1
- Chemical Name:
- Atipamezole hydrochloride
- Synonyms
- Antisedan;Unii-2W4279571x;Atipamezole HCL;MPV1248 hydrochloride;MPV-1248 hydrochloride;MPV 1248 hydrochloride;Atipamezole hydrochloride;Atipamezole HCl (MPV-1248);Atipamezole hydrochloride, >=99%;4-(2-ethylindan-2-yl)-1H-imidazole
- CBNumber:
- CB81210097
- Molecular Formula:
- C14H16N2.HCl
- Molecular Weight:
- 248.75
- MDL Number:
- MFCD06407819
- MOL File:
- 104075-48-1.mol
| Melting point | 211-215° |
|---|---|
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Off-White |
| Merck | 14,861 |
| InChI | InChI=1S/C14H16N2.ClH/c1-2-14(13-9-15-10-16-13)7-11-5-3-4-6-12(11)8-14;/h3-6,9-10H,2,7-8H2,1H3,(H,15,16);1H |
| InChIKey | PCCVCJAQMHDWJY-UHFFFAOYSA-N |
| SMILES | C1(CC)(CC2=C(C=CC=C2)C1)C1=CNC=N1.Cl |
| CAS DataBase Reference | 104075-48-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 2W4279571X |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332-H312-H302 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501-P280-P302+P352-P312-P322-P363-P501 | |||||||||
| RTECS | NI6139000 | |||||||||
| HS Code | 2933.29.2000 | |||||||||
| Toxicity | LD50 in male, female rats (mg/kg): >50, 44 s.c. (Scheinin) | |||||||||
| NFPA 704 |
|
Atipamezole hydrochloride price More Price(39)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | A2956 | Atipamezole Hydrochloride >98.0%(HPLC)(T) | 104075-48-1 | 25mg | $299 | 2024-03-01 | Buy |
| TCI Chemical | A2956 | Atipamezole Hydrochloride >98.0%(HPLC)(T) | 104075-48-1 | 100mg | $596 | 2024-03-01 | Buy |
| Alfa Aesar | H37332 | Atipamezole (hydrochloride) | 104075-48-1 | 1g | $406 | 2021-12-16 | Buy |
| Alfa Aesar | H37332 | Atipamezole (hydrochloride) | 104075-48-1 | 250mg | $123 | 2021-12-16 | Buy |
| Cayman Chemical | 9001181 | Atipamezole (hydrochloride) ≥98% | 104075-48-1 | 5mg | $72 | 2024-03-01 | Buy |
Atipamezole hydrochloride Chemical Properties,Uses,Production
Uses
Atipamezole Hydrochloride, is the a synthetic α2-adrenergic antagonist, usually used to reverse the sedative and analgesic effects of dexmedetomidine and medetomidine in dogs. It has also been shown to be used as possible anti-Parkinsonian drug in humans.
Biological Activity
Selective α 2 -adrenergic receptor antagonist (K i values are 1.1, 1.0, 0.89, 1300 and 6500 nM for α 2A , α 2B , α 2C , α 1A and α 1B receptors respectively). Brain penetrant.
Side effects
A transient hypotensive effect has been observed during the first 10 minutes post-injection of atipamezole hydrochloride. In rare cases, hyperactivity, tachycardia, salivation, atypical vocalization, muscle tremor, vomiting, increased respiratory rate, uncontrolled urination, and defecation may occur. In very rare cases, recurrence of sedation may occur, or the recovery time may not be shortened after administration of atipamezole. In cats, when using low doses to reverse the effects of medetomidine or dexmedetomidine partially, the possibility of hypothermia (even when aroused from sedation) should be guarded against.
Veterinary Drugs and Treatments
Atipamezole is labeled for use as a reversal agent for medetomidine and dexmedetomidine. It potentially could be useful for reversal of other alpha2-adrenergic agonists as well (e.g., amitraz, xylazine, clonidine, tizanidine, brimonidine).
storage
Desiccate at RT
Atipamezole hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Liaoning Pharmaceutical Innovation Co., Ltd | +8616588669988 | sales@pipharma.com.cn | China | 151 | 58 |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5889 | 58 |
| Hangzhou ICH Biofarm Co., Ltd | +86-0571-28186870; +undefined8613073685410 | sales@ichemie.com | China | 1010 | 58 |
| airuikechemical co., ltd. | +86-18353166132 +86-18353166132 | sales02@airuikechemical.com | China | 983 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29793 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 | product@chemlin.com.cn | CHINA | 3009 | 60 |
| Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
Related articles
- A synthetic α2-adrenergic antagonist-Atipamezole hydrochloride
- ANTISEDAN (atipamezole hydrochloride) is a synthetic α2-adrenergic antagonist.
- Feb 29，2024
View Lastest Price from Atipamezole hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-02 | Atipamezole hydrochloride
104075-48-1
|
US $10317.00 / g | 1g | 99 | 10kg | Baoji Guokang Bio-Technology Co., Ltd. | |
 |
2024-12-24 | atipamezole hcl
104075-48-1
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | |
 |
2024-11-19 | Atipamezole hydrochloride
104075-48-1
|
US $47.00-135.00 / mg | 96.71% | 10g | TargetMol Chemicals Inc. |
-
- Atipamezole hydrochloride
104075-48-1
- US $10317.00 / g
- 99
- Baoji Guokang Bio-Technology Co., Ltd.
-
- atipamezole hcl
104075-48-1
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
-
- Atipamezole hydrochloride
104075-48-1
- US $47.00-135.00 / mg
- 96.71%
- TargetMol Chemicals Inc.