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[1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2)

[1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2) structure

CAS No.: 2716849-01-1

Chemical Name:: [1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2)

Synonyms: [1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2);2-Amino-3-[5'-(2-amino-2-carboxy-ethyl)-6,2'-dihydroxy-biphenyl-3-yl]-propionic acid dihydrochloride

CBNumber:: CB812116935

Molecular Formula:: C18H21ClN2O6

Molecular Weight:: 396.82

MDL Number:

MOL File:: 2716849-01-1.mol

Last updated:2023-04-23 13:52:06

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[1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2) Properties

solubility	DMF: 5 mg/ml; DMSO: 10 mg/ml; Ethanol: 15 mg/ml; PBS (pH 7.2): 10 mg/ml
form	A solid

[1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2) price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	27657	Dityrosine (hydrochloride) ≥95%	2716849-01-1	500 μg	$96	2024-03-01	Buy
Cayman Chemical	27657	Dityrosine (hydrochloride) ≥95%	2716849-01-1	1 mg	$144	2024-03-01	Buy
Cayman Chemical	27657	Dityrosine (hydrochloride) ≥95%	2716849-01-1	5 mg	$669	2024-03-01	Buy
Cayman Chemical	27657	Dityrosine (hydrochloride) ≥95%	2716849-01-1	10 mg	$954	2024-03-01	Buy

Product number	Packaging	Price	Buy
27657	500 μg	$96	Buy
27657	1 mg	$144	Buy
27657	5 mg	$669	Buy
27657	10 mg	$954	Buy

[1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2) Chemical Properties,Uses,Production

Description

Dityrosine is a protein oxidation product that is formed by intermolecular cross-linking of two tyrosyl radicals generated from the interaction between reactive oxygen species (ROS) and tyrosine.^1,2 Intragastric administration of dityrosine (320 μg/kg per day) decreases hippocampal expression of the NMDA receptor subunits Nr1, Nr2a, and Nr2b and induces memory impairments in a novel object recognition test in mice.² It increases fasting blood glucose levels and decreases plasma insulin levels and pancreatic expression of the insulin synthesis-related genes Ins2, Pdx1, and MafA in mice.³ Increased levels of dityrosine are positively correlated with various diseases, including autism spectrum disorder, cataracts, Alzheimer’s disease, Parkinson’s disease, atherosclerosis, and cystic fibrosis.^4,5

References

1. Amadò, R., Aeschbach, R., and Neukom, H. Dityrosine: In vitro production and characterization Methods Enzymol. 107,377-388(1984).
2. Ran, Y., Yan, B., Li, Z., et al. Dityrosine administration induces novel object recognition deficits in young adulthood mice Physiol. Behav. 164(Pt A),292-299(2016).
3. Ding, Y.Y., Li, Z.Q., Cheng, X.R., et al. Dityrosine administration induces dysfunction of insulin secretion accompanied by diminished thyroid hormones T3 function in pancreas of mice Amino Acids 49(8),1401-1414(2017).
4. Anwar, A., Abruzzo, P.M., Pasha, S., et al. Advanced glycation endproducts, dityrosine and arginine transporter dysfunction in autism - a source of biomarkers for clinical diagnosis Mol. Autism 9,3(2018).
5. DiMarco, T., and Giulivi, C. Current analytical methods for the detection of dityrosine, a biomarker of oxidative stress, in biological samples Mass Spectrom. Rev. 26(1),108-120(2007).

[1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2) Preparation Products And Raw materials

Raw materials

Preparation Products

[1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2) Suppliers

Global( 5)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
JW & Y Pharmlab Co., Ltd.	021-64340559 13651849907	xinyu_shi@jwypharmlab.com.cn	China	6080	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19707	58
Shanghai Kaisen Biotechnology Co., Ltd	17558870519	3549952815@qq.com	China	2997	58

Supplier	Advantage
JW & Y Pharmlab Co., Ltd.	58
Shanghai Yifei Biotechnology Co. , Ltd.	58
TargetMol Chemicals Inc.	58
Shanghai Kaisen Biotechnology Co., Ltd	58

[1,1'-Biphenyl]-3,3'-dipropanoic acid, α3,α3'-diamino-6,6'-dihydroxy-, hydrochloride (1:2) 2-Amino-3-[5'-(2-amino-2-carboxy-ethyl)-6,2'-dihydroxy-biphenyl-3-yl]-propionic acid dihydrochloride 2716849-01-1