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ChemicalBook >> CAS DataBase List >>Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1)

Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1)

Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1) Structure
Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1) structure
CAS No.
2309312-90-9
Chemical Name:
Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1)
Synonyms
1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone,monohydrochloride;Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1)
CBNumber:
CB812155248
Molecular Formula:
C22H23ClF6N2O2
Molecular Weight:
496.88
MDL Number:
MOL File:
2309312-90-9.mol
Last updated:2023-04-23 13:52:06
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Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1) Properties

solubility DMF: 5 mg/ml; DMF:PBS(pH 7.2)(1:6): 0.16 mg/ml; DMSO: 3 mg/ml; Ethanol: 1.6 mg/ml
form A crystalline solid

Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1) price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 12071 SR 1555 (hydrochloride) ≥98% 2309312-90-9 1 mg $32 2024-03-01 Buy
Cayman Chemical 12071 SR 1555 (hydrochloride) ≥98% 2309312-90-9 5 mg $106 2024-03-01 Buy
Cayman Chemical 12071 SR 1555 (hydrochloride) ≥98% 2309312-90-9 10 mg $186 2024-03-01 Buy
Cayman Chemical 12071 SR 1555 (hydrochloride) ≥98% 2309312-90-9 25 mg $404 2024-03-01 Buy
Product number Packaging Price Buy
12071 1 mg $32 Buy
12071 5 mg $106 Buy
12071 10 mg $186 Buy
12071 25 mg $404 Buy

Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1) Chemical Properties,Uses,Production

Description

Retinoic acid receptor-related nuclear receptor γ (RORγ) plays a central role in T cell differentiation, particularly in the development of TH17 cells, which are implicated in autoimmune diseases like multiple sclerosis and rheumatoid arthritis.1,2 SR 1555 is a selective ligand of RORγ (IC50 = 1 μM).3 It does not bind RORα, LXR, or FXR. SR 1555 acts as an inverse agonist of RORγ, inhibiting endogenous IL-17A gene expression in mouse splenocytes and suppressing differentiation of TH17 cells when cultured under TH17 polarizing conditions.3 Moreover, SR 1555 stimulates T regulatory development when cultured under T regulatory polarizing conditions, unlike digoxin and ursolic acid.3

References

1. Ivanov, I.I., McKenzie, B.S., Zhou, L., et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells Cell 126(6),1121-1133(2006).
2. Solt, L.A., Kumar, N., Nuhant, P., et al. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand Nature 472(7344),491-494(2011).
3. Solt, L.A., Kumar, N., He, Y., et al. Identification of a selective RORγ ligand that suppresses TH17 cells and stimulates T regulatory cells ACS Chem. Biol. 7,1515-1519(2012).

Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1) Preparation Products And Raw materials

Raw materials

Preparation Products

Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1) Suppliers

Global( 2)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
Shanghai Yifei Biotechnology Co. , Ltd. 58
Ethanone, 1-[4-[[4'-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl][1,1'-biphenyl]-4-yl]methyl]-1-piperazinyl]-, hydrochloride (1:1) 1-(4-((4'-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-[1,1'-biphenyl]-4-yl)methyl)piperazin-1-yl)ethanone,monohydrochloride 2309312-90-9 C22H23ClF6N2O2