ChemicalBook >> CAS DataBase List >>7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel-

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel-

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel- structure

CAS No.: 1180158-99-9

Chemical Name:: 7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel-

Synonyms: BVB-808;7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel-

CBNumber:: CB812259205

Molecular Formula:: C28H32F2N8O

Molecular Weight:: 534.6

MDL Number:

MOL File:: 1180158-99-9.mol

Last updated:2023-07-12 16:57:17

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7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel- Properties

Boiling point	660.0±65.0 °C(Predicted)
Density	1.41±0.1 g/cm3(Predicted)
pka	8.72±0.60(Predicted)

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel- Chemical Properties,Uses,Production

Description

BVB-808 is a selective Jak2 type 1 inhibitor. Janus kinases are critical components of signaling pathways that regulate hematopoiesis. Mutations of the non-receptor tyrosine kinase JAK2 are found in many BCR-ABL-negative myeloproliferative neoplasms. Preclinical results support that JAK2 inhibitors could show efficacy in treating chronic myeloproliferative neoplasms. JAK2 has also been postulated to play a role in BCR-ABL signal transduction. Therefore, inhibitors of JAK2 kinases are turning into therapeutic strategies for treatment of chronic myelogenous leukemia (CML).

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel- Preparation Products And Raw materials

Raw materials

Preparation Products

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel- Suppliers

Global( 1)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	18470	58

Supplier	Advantage
TargetMol Chemicals Inc.	58

7H-Pyrrolo[2,3-d]pyrimidin-2-amine, 7-[3,5-difluoro-4-(4-morpholinylmethyl)phenyl]-N-[6-[(3R,5S)-3,5-dimethyl-1-piperazinyl]-3-pyridinyl]-, rel- BVB-808 1180158-99-9 C28H32F2N8O