Conivaptan hydrochloride
- CAS No.
- 168626-94-6
- Chemical Name:
- Conivaptan hydrochloride
- Synonyms
- Vaprisol;Conivaptan HCI;Conivaptan HCl;Unii-75L57R6X36;Conivaptan HCl (YM 087);Conivaptan hydrochkoride;Conivaptan hydrochloride;Conivaptan hydrochloride [usan];Conivaptan hydrochloride, >=99%;Conivaptan hydrochloride USP/EP/BP
- CBNumber:
- CB81246922
- Molecular Formula:
- C32H26N4O2.HCl
- Molecular Weight:
- 535.04
- MDL Number:
- MFCD00945712
- MOL File:
- 168626-94-6.mol
- MSDS File:
- SDS
Melting point | >250° |
---|---|
storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
solubility | DMSO (Slightly), Methanol (Slightly) |
form | Solid |
color | White to Off-White |
InChIKey | BTYHAFSDANBVMJ-UHFFFAOYSA-N |
SMILES | C12=CC=CC=C1N(CCC1N=C(C)NC2=1)C(=O)C1=CC=C(NC(=O)C2C=CC=CC=2C2=CC=CC=C2)C=C1.Cl |
FDA UNII | 75L57R6X36 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302 |
Precautionary statements | P501-P270-P264-P301+P312+P330 |
Conivaptan hydrochloride price More Price(38)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 23728 | Conivaptan (hydrochloride) ≥95% | 168626-94-6 | 5mg | $68 | 2024-03-01 | Buy |
Cayman Chemical | 23728 | Conivaptan (hydrochloride) ≥95% | 168626-94-6 | 10mg | $121 | 2024-03-01 | Buy |
Cayman Chemical | 23728 | Conivaptan (hydrochloride) ≥95% | 168626-94-6 | 25mg | $268 | 2024-03-01 | Buy |
Cayman Chemical | 23728 | Conivaptan (hydrochloride) ≥95% | 168626-94-6 | 50mg | $469 | 2024-03-01 | Buy |
Tocris | 6830 | Conivaptanhydrochloride ≥98%(HPLC) | 168626-94-6 | 50 | $214 | 2021-12-16 | Buy |
Conivaptan hydrochloride Chemical Properties,Uses,Production
Description
Arginine vasopressin is intimately involved in volume homeostasis, and elevated levels of arginine vasopressin are responsible for the pathogenesis and progression of diseases with an imbalance of sodium and water, particularly congestive heart failure. To restore homeostasis, antagonism of vasopressin receptors is a practical solution. As such, conivaptan has been developed and launched as a dual V1a and V2 vasopressin receptor antagonist. As a competitive, reversible inhibitor of both subtypes, conivaptan can modulate systemic vascular resistance through the V1a receptor (Ki ? 0.48 nM) distributed in vascular smooth muscle cells, cardiomyocytes, hepatocytes, and platelets and blocks the renal V2 receptor (Ki ? 3.04 nM) resulting in enhanced diuresis, thereby increasing serum sodium concentration and reducing total body volume. Currently, the drug is approved for the management of refractory hyponatremia and potentially lifethreatening sodium and water imbalance, but it has shown promise as a potential treatment option for other diseases, such as congestive heart failure, syndrome of antidiuretic hormone, diabetes insipidus, and liver cirrhosis.
Description
Conivaptan is an antagonist of the arginine vasopressin (AVP) receptors V1A and V2 (Kis = 0.48 and 3.04 nM for rat liver V1A and kidney V2, respectively). It also competitively inhibits oxytocin binding to rat uterine oxytocin receptors (Ki = 44 nM) but has no effect on AVP binding to anterior pituitary V1B receptors at concentrations up to 100 μM in a radioligand binding assay. Conivaptan suppresses AVP-induced increases in intracellular calcium in vascular smooth muscle cells (VSMCs) in vitro and the pressor response in pithed rats. Conivaptan (0.01-0.3 mg/kg, i.v.) increases urine output and decreases urine osmolality in dehydrated conscious rats in a dose-dependent manner. It also reduces brain edema and blood-brain barrier disruption in a mouse experimental stroke model.
Chemical Properties
White to Off-White Solid
Originator
Yamanouchi (Japan)
Uses
Conivaptan is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist).
Uses
Used in treatment of congestive heart failure.
Definition
ChEBI: The hydrochloride salt of conivaptan. It is an antagonist for two of the three types of arginine vasopressin (AVP) receptors, V1a and V2, and is used for the treatment of hyponatraemia (low blood sodium levels) cau ed by syndrome of inappropriate antidiuretic hormone (SIADH).
brand name
Vaprisol (Astellas).
storage
Desiccate at RT
Conivaptan hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Hefei TianRui Pharmaceutical Chemical Co., Ltd. | +86-0551-68665055 +86-+86-18616906106 | sales@trywchem.com | China | 129 | 58 |
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 | sales@sdperfect.com | China | 294 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21677 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ | sales03@shyrchem.com | CHINA | 738 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29901 | 58 |
Jinan Shengqi pharmaceutical Co,Ltd | 86+18663751872 | christine@shengqipharm.com | CHINA | 491 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Conivaptan hydrochloride manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-12 | Conivaptan HCl
168626-94-6
|
US $0.00 / g | 1g | 98% HPLC | 100kg | shandong perfect biotechnology co.ltd | ||
2022-09-30 | Conivaptan hydrochloride
168626-94-6
|
US $0.00-0.00 / kg | 1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. | ||
2021-08-13 | Conivaptan hydrochloride USP/EP/BP
168626-94-6
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
- Conivaptan HCl
168626-94-6
- US $0.00 / g
- 98% HPLC
- shandong perfect biotechnology co.ltd
- Conivaptan hydrochloride
168626-94-6
- US $0.00-0.00 / kg
- 98%
- Henan Aochuang Chemical Co.,Ltd.
- Conivaptan hydrochloride USP/EP/BP
168626-94-6
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited