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CB 3717

CB 3717 structure

CAS No.: 76849-19-9

Chemical Name:: CB 3717

Synonyms: PDDF;CB 3717;8-dideazafolic acid;N(sup 10)-Propargyl-5;LTKHPMDRMUCUEB-IBGZPJMESA-N;10-Propargyl-5,8-dideazafolate;10-Propargyl-5,8-dideazafolic acid;N(sup 10)-Propargyl-5,8-dideazafolic acid;N¹⁰)-PROPARGYL-5,8-DIDEAZAFOLIC ACID;N-[p-[Propargyl(2-amino-4-hydroxyquinazolin-6-ylmethyl)amino]benzoyl]-L-glutamic acid

CBNumber:: CB81316159

Molecular Formula:: C24H23N5O6

Molecular Weight:: 477.47

MDL Number:: MFCD00869489

MOL File:: 76849-19-9.mol

Last updated:2024-03-16 16:54:43

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CB 3717 Chemical Properties,Uses,Production

Description

CB 3717, a potent inhibitor of thymidylate synthase, is toxic for cell lines with altered dihydrofolate reductase; and homofolate, a de novo purine inhibitor requiring dihydrofolate reductase for activation, is effective in reductase-amplified lines.

Definition

ChEBI: CB3717 is a N-acyl-L-glutamic acid.

Hazard

A poison.

CB 3717 Preparation Products And Raw materials

Raw materials

Preparation Products

CB 3717 Suppliers

Global( 4)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	027-88013699 17354350817	Ryan@jiutian-bio.com	China	7113	58
SPIRO PHARMA		eric_feng1954@126.com	China	9254	55
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19696	58

Supplier	Advantage
TargetMol Chemicals Inc.	58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd	58
SPIRO PHARMA	55
TargetMol Chemicals Inc.	58

CB 3717 10-Propargyl-5,8-dideazafolate 10-Propargyl-5,8-dideazafolic acid N-[4-[[(2-Amino-1,4-dihydro-4-oxoquinazolin-6-yl)methyl]-2-propynylamino]benzoyl]-L-glutamic acid N-[p-[Propargyl(2-amino-4-hydroxyquinazolin-6-ylmethyl)amino]benzoyl]-L-glutamic acid PDDF LTKHPMDRMUCUEB-IBGZPJMESA-N L-Glutamic acid, N-[4-[[(2-amino-3,4-dihydro-4-oxo-6-quinazolinyl)methyl]-2-propyn-1-ylamino]benzoyl]- 8-dideazafolic acid N(sup 10)-Propargyl-5 N(sup 10)-Propargyl-5,8-dideazafolic acid N¹⁰)-PROPARGYL-5,8-DIDEAZAFOLIC ACID 76849-19-9