choto-san

Pharmacology

Choto-san (Gouteng-san) is a Japanese (Kampo) herbal medicine with apparent neuroprotective effect against glutamate- induced neuronal death (Itoh et al., 1999; Watanabe et al., 2003). Choto-san was administered for 12 weeks to 10 patients with post-stroke VCI; P3 event-related brain potentials, MMSE and verbal fluency tests significantly improved with treatment (Yamaguchi et al., 2004). In a larger trial, Choto-san resulted in improvement of ADLs, global rating and subjective and psychiatric symptoms (Itoh et al., 1999).