Neuregulin-1
- CAS No.
- Chemical Name:
- Neuregulin-1
- Synonyms
- NRG1-b1;Neuregulin-1;Heregulin beta -1 human
- CBNumber:
- CB81339398
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- Mol file
| storage temp. | -20°C |
|---|---|
| form | lyophilized |
| color | white to off-white |
| FDA UNII | 6M7LS9PZV4 |
Neuregulin-1 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SRP3055 | Heregulin beta -1 human Animal-component free, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture | 50μG | $644 | 2023-06-20 | Buy | |
| Usbiological | 027063 | Neuregulin 1 | 96Tests | $851 | 2021-12-16 | Buy | |
| Usbiological | 156056 | Neuregulin 1 | 10ug | $329 | 2021-12-16 | Buy | |
| Usbiological | 156055 | Neuregulin 1 | 10ug | $329 | 2021-12-16 | Buy | |
| Usbiological | 156057 | Neuregulin 1 | 10ug | $329 | 2021-12-16 | Buy |
Neuregulin-1 Chemical Properties,Uses,Production
Uses
Heregulin-β1 human has been used in the culture medium for the maintenance of Schwann cells. It has been used to study P-Rex1 (PI(3,4,5)P3-dependent Rac exchanger 1)-driven fibroblast invasiveness.
General Description
Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). HRG1-β1 (heregulin-β1, also referred to as NRG1-β1) contains an Ig (immunoglobulin) domain and an EGF (epidermal growth factor)-like domain that is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. The gene HRG1-β1 is mapped to human chromosome 8p12. Recombinant human Heregulin-β1 is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulin-β1 (65 amino acid residues).
Biochem/physiol Actions
To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 (neuregulin1) gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms release soluble growth factors. HRG1-β1 (heregulin-β1, also referred to as NRG1-β1) binding to receptor tyrosine kinases erb3 and erb4 induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity, which leads to tyrosine phosphorylation. Although HRG1-β1 biological effects is still unclear, it has been found to promote motility and invasiveness of breast cancer cells which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF).
Neuregulin-1 Preparation Products And Raw materials
Raw materials
Preparation Products
Neuregulin-1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Tongwei Biotechnology Co., Ltd | -- | 253437001@qq.com | CHINA | 6378 | 58 |
| Guangzhou Weijia Technology Co., Ltd. | -- | WHIGA22@126.COM | CHINA | 6748 | 58 |
| Shanghai Jingke Chemical Technology Co., Ltd. | -- | jingkehuaxue@163.com | CHINA | 6974 | 58 |
| Shanghai Qumai Biological Technology Co., Ltd. | -- | 13770640776@189.cn | CHINA | 6227 | 58 |
| Nanjing Sai Ruirui Biotechnology Co., Ltd. | -- | sales@shrbio.com | CHINA | 6873 | 58 |
| Shanghai Hao Biological Technology Co., Ltd. | -- | market@xlswkj.com | CHINA | 6805 | 58 |
| Riedel-de Haen AG | -- | United States | 6825 | 87 |