icFSP1
- CAS No.
- 1115910-36-5
- Chemical Name:
- icFSP1
- Synonyms
- icFSP1;Benzeneacetamide, 3,4,5-trimethoxy-N-[4-(2-methyl-4-oxo-3(4H)-quinazolinyl)phenyl]-;N-(4-(2-Methyl-4-oxoquinazolin-3(4H)-yl)phenyl)-2-(3,4,5-trimethoxyphenyl)acetamide
- CBNumber:
- CB813695134
- Molecular Formula:
- C26H25N3O5
- Molecular Weight:
- 459.49
- MDL Number:
- MOL File:
- 1115910-36-5.mol
icFSP1 Chemical Properties,Uses,Production
Uses
icFSP1 is a potent ferroptosis suppressor protein-1 (FSP1) inhibitor. icFSP1 triggers subcellular relocalization of FSP1 from the membrane and FSP1 condensation, in synergism with GPX4 inhibition. icFSP1 induces ferroptosis. icFSP1 shows antitumor activity against melanoma.[1].
Biological Activity
Selective and efficacious in vivo inhibitor of ferroptosis-suppressor-protein 1 (FSP1); ferroptosis inducer.
icFSP1 is a selective and efficacious in vivo inhibitor of ferroptosis-suppressor-protein 1 (FSP1). icFSP1 triggers subcellular relocalization of FSP1 from the membrane and initiate FSP1 reversible aggregation into liquid droplet-like structures before ferroptosis initiation. It synergizes with ferroptosis inducing agents to potentiate the ferroptotic cell death response.
in vivo
icFSP1 (50?mg/kg, i.p., twice daily) impairs tumour growth in a tumour-bearing (Gpx4 and Fsp1 double knockout B16F10 cells overexpressing hFSP1) mouse model[1].
| Animal Model: | Tumour-bearing (Gpx4 and Fsp1 double knockout B16F10 cells overexpressing hFSP1) mouse (C57BL/6J) model[1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection (i.p.), twice daily |
| Result: | Inhibited tumour growth and decreased tumour weight, without affecting body weight. Increased the abundance of hFSP1 condensates and immunoreactivity to 4-hydroxynonenal (4-HNE). |
References
[1] Toshitaka Nakamura, et al. Phase separation of FSP1 promotes ferroptosis. Nature. 2023 Jul;619(7969):371-377. DOI:10.1038/s41586-023-06255-6
icFSP1 Preparation Products And Raw materials
Raw materials
Preparation Products
icFSP1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4601 | 55 | |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 6188 | 55 |
| DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9409 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 62072 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24641 | 58 |
| Nantong QuanYi Biotechnology Co., Ltd | 0513-66337626 18051384581 | sales@chemhifuture.com | China | 5236 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| Hubei wei shi reagent group ltd., company | 027-59101766 13125137661 | 2853877621@qq.com | China | 7901 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd | 025-58851090 17714375163 | 2881759498@qq.com | China | 13012 | 58 |
