Potassium bis(trimethylsilyl)amide
- CAS No.
- 40949-94-8
- Chemical Name:
- Potassium bis(trimethylsilyl)amide
- Synonyms
- KHMDS;POTASSIUM HEXAMETHYLDISILAZIDE;HEXAMETHYLDISILAZANE POTASSIUM SALT;HMDS K;KHMDS 0.7M;PotassiumHMDS;Potassium bis(trimet;Potassium bis(trimethyL;potassiumhexamethyldisil;POTASSIUM HEXAMETHYLDISLAZANE
- CBNumber:
- CB8139300
- Molecular Formula:
- C6H18KNSi2
- Molecular Weight:
- 199.48
- MDL Number:
- MFCD00010330
- MOL File:
- 40949-94-8.mol
- MSDS File:
- SDS
Melting point | 194-195°C |
---|---|
Boiling point | 111 °C |
Density | 0.877 g/mL at 25 °C |
vapor density | 3.2 (vs air) |
vapor pressure | 54 mm Hg ( 25 °C) |
refractive index | 1.4920 |
Flash point | 45 °F |
storage temp. | Refrigerator |
solubility | Miscible with terahydrofuran, ether, benzene and toluene. |
form | Liquid |
Specific Gravity | 0.877 |
color | clear to slightly hazy yellow |
Water Solubility | Reacts with water. |
Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
Sensitive | Moisture Sensitive |
BRN | 4006754 |
CAS DataBase Reference | 40949-94-8(CAS DataBase Reference) |
EPA Substance Registry System | Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS05 |
---|---|
Signal word | Danger |
Hazard statements | H314 |
Precautionary statements | P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338 |
Hazard Codes | C,F,Xn |
Risk Statements | 14-34-67-65-63-48/20-11-40-36/37/38-19-37 |
Safety Statements | 26-36/37/39-45-62-43-46-16-36/37 |
RIDADR | UN 3263 8/PG 3 |
WGK Germany | 3 |
F | 1-3-10 |
TSCA | No |
HazardClass | 3 |
PackingGroup | II |
HS Code | 29319090 |
Potassium bis(trimethylsilyl)amide price More Price(36)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 277304 | Potassium bis(trimethylsilyl)amide solution 0.5 M in toluene | 40949-94-8 | 4x25ml | $91.6 | 2024-03-01 | Buy |
Sigma-Aldrich | 277304 | Potassium bis(trimethylsilyl)amide solution 0.5 M in toluene | 40949-94-8 | 2l | $880 | 2024-03-01 | Buy |
TCI Chemical | H0893 | Potassium Bis(trimethylsilyl)amide (11% in Toluene, ca. 0.5mol/L) | 40949-94-8 | 100mL | $89 | 2021-12-16 | Buy |
TCI Chemical | H0893 | Potassium Bis(trimethylsilyl)amide (11% in Toluene, ca. 0.5mol/L) | 40949-94-8 | 500mL | $268 | 2021-12-16 | Buy |
Sigma-Aldrich | 775061 | Potassium bis(trimethylsilyl)amide solution 1.0 M in 2-methyltetrahydrofuran | 40949-94-8 | 4x25ml | $327 | 2024-03-01 | Buy |
Potassium bis(trimethylsilyl)amide Chemical Properties,Uses,Production
Chemical Properties
Colorless to amber solution
Uses
Potassium Hexamethyldisilazide is widely used as a Sterically Hindered Base for Enolate Generation in Selective Formation of Linear Conjugated Dienolates and Alkyl (Z)-3-Alkenoates.
Uses
Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.
Uses
Potassium bis(trimethylsilyl)amide is a strong base used in the alkylation carbonyl compounds.1
Preparation
Potassium Hexamethyldisilazide is prepared and isolated by the procedure of Wannagat and Niederpruem. A more convenient in situ generation from potassium hydride and hexamethyldisilane is described by Brown.
General Description
This product, 1.0 M in 2-methyltetrahydrofuran aligns with "Safer Solvents and Auxiliaries", "Use of Renewable Feedstocks" and "Inherently Safer Chemistry for Accident Prevention".
Potassium bis(trimethylsilyl)amide Preparation Products And Raw materials
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
airuikechemical co., ltd. | +undefined86-15315557071 | sales02@airuikechemical.com | China | 983 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1811 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21669 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
Zjartschem | +86-571 87238903 | jocelynpan@zjarts.com | CHINA | 993 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29897 | 58 |
Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
Shanghai Worldyang Chemical Co.,Ltd. | +86-021-56795779 +8613651600618 | sales@worldyachem.com | China | 1080 | 58 |
Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5909 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
View Lastest Price from Potassium bis(trimethylsilyl)amide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-08 | potassium bis(trimethylsilyl)amide
40949-94-8
|
US $0.00-0.00 / Kg | 1Kg | 99.9% | 200tons | airuikechemical co., ltd. | ||
2021-07-02 | Potassium bis(trimethylsilyl)amide
40949-94-8
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | ||
2019-07-10 | Potassium hexamethyldisilazide
40949-94-8
|
US $1.00 / KG | 1KG | 99% | 25kg | Career Henan Chemical Co |
- potassium bis(trimethylsilyl)amide
40949-94-8
- US $0.00-0.00 / Kg
- 99.9%
- airuikechemical co., ltd.
- Potassium bis(trimethylsilyl)amide
40949-94-8
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
- Potassium hexamethyldisilazide
40949-94-8
- US $1.00 / KG
- 99%
- Career Henan Chemical Co