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Potassium bis(trimethylsilyl)amide

Potassium bis(trimethylsilyl)amide structure

CAS No.: 40949-94-8

Chemical Name:: Potassium bis(trimethylsilyl)amide

Synonyms: KHMDS;POTASSIUM HEXAMETHYLDISILAZIDE;HEXAMETHYLDISILAZANE POTASSIUM SALT;HMDS K;KHMDS 0.7M;PotassiumHMDS;Potassium bis(trimet;Potassium bis(trimethyL;potassiumhexamethyldisil;POTASSIUM HEXAMETHYLDISLAZANE

CBNumber:: CB8139300

Molecular Formula:: C6H18KNSi2

Molecular Weight:: 199.48

MDL Number:: MFCD00010330

MOL File:: 40949-94-8.mol

MSDS File:: SDS

Last updated:2024-04-08 17:36:13

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Potassium bis(trimethylsilyl)amide Properties

Melting point	194-195°C
Boiling point	111 °C
Density	0.877 g/mL at 25 °C
vapor density	3.2 (vs air)
vapor pressure	54 mm Hg ( 25 °C)
refractive index	1.4920
Flash point	45 °F
storage temp.	Refrigerator
solubility	Miscible with terahydrofuran, ether, benzene and toluene.
form	Liquid
Specific Gravity	0.877
color	clear to slightly hazy yellow
Water Solubility	Reacts with water.
Hydrolytic Sensitivity	8: reacts rapidly with moisture, water, protic solvents
Sensitive	Moisture Sensitive
BRN	4006754
CAS DataBase Reference	40949-94-8(CAS DataBase Reference)
EPA Substance Registry System	Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)-, potassium salt (1:1) (40949-94-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05
Signal word	Danger
Hazard statements	H314
Precautionary statements	P260-P280-P301+P330+P331-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes	C,F,Xn
Risk Statements	14-34-67-65-63-48/20-11-40-36/37/38-19-37
Safety Statements	26-36/37/39-45-62-43-46-16-36/37
RIDADR	UN 3263 8/PG 3
WGK Germany	3
F	1-3-10
TSCA	No
HazardClass	3
PackingGroup	II
HS Code	29319090

Potassium bis(trimethylsilyl)amide price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	277304	Potassium bis(trimethylsilyl)amide solution 0.5 M in toluene	40949-94-8	4x25ml	$91.6	2024-03-01	Buy
Sigma-Aldrich	277304	Potassium bis(trimethylsilyl)amide solution 0.5 M in toluene	40949-94-8	2l	$880	2024-03-01	Buy
TCI Chemical	H0893	Potassium Bis(trimethylsilyl)amide (11% in Toluene, ca. 0.5mol/L)	40949-94-8	100mL	$89	2021-12-16	Buy
TCI Chemical	H0893	Potassium Bis(trimethylsilyl)amide (11% in Toluene, ca. 0.5mol/L)	40949-94-8	500mL	$268	2021-12-16	Buy
Sigma-Aldrich	775061	Potassium bis(trimethylsilyl)amide solution 1.0 M in 2-methyltetrahydrofuran	40949-94-8	4x25ml	$327	2024-03-01	Buy

Product number	Packaging	Price	Buy
277304	4x25ml	$91.6	Buy
277304	2l	$880	Buy
H0893	100mL	$89	Buy
H0893	500mL	$268	Buy
775061	4x25ml	$327	Buy

Potassium bis(trimethylsilyl)amide Chemical Properties,Uses,Production

Chemical Properties

Colorless to amber solution

Uses

Potassium Hexamethyldisilazide is widely used as a Sterically Hindered Base for Enolate Generation in Selective Formation of Linear Conjugated Dienolates and Alkyl (Z)-3-Alkenoates.

Uses

Potassium Bis(trimethylsilyl)amide (1M in THF) is used in the preparation of 5-azacytidine, an antineoplastic drug. Also applied in the preparation of β3-AR agonists used in anti-stress formulations. It is also used as a reagent in the preparation of lanthanide complexes employed in selective cyclization reactions.

Uses

Potassium bis(trimethylsilyl)amide is a strong base used in the alkylation carbonyl compounds.1

Preparation

Potassium Hexamethyldisilazide is prepared and isolated by the procedure of Wannagat and Niederpruem. A more convenient in situ generation from potassium hydride and hexamethyldisilane is described by Brown.

General Description

This product, 1.0 M in 2-methyltetrahydrofuran aligns with "Safer Solvents and Auxiliaries", "Use of Renewable Feedstocks" and "Inherently Safer Chemistry for Accident Prevention".

Synthesis

Potassium bis(trimethylsilyl)amide is an important non-nucleophilic base widely used in organic synthesis. The main method for its preparation is are interaction of hexamethyldisilazane with potassium amide) potassium hydride, potassium metal, mad styrene, isoprene, or naphthalene as electron acceptors.
An oven-dried 100 ml round-bottom flask was charged with KH (3.22 g, 20.1 mmol, 25 wt. 96 in oil) and flushed with argon. The hydride was then washed with hexane (4x5 ml). To the flask was fitted, a reflux condenser was made, and then THF (20 ml) and bis(trimethylsi1yl)amine (3.81 ml, 18.1 mmol) were added. The resultant slurry was sonicated until the hydrogen gas evolution had ceased, and almost all the potassium hydride had been consumed (3.25 h). The slurry was allowed to settle, and the supernatant was then cannulated into a Schlenk flask. Titration4 for the amide base concentration showed it to be 0.80 M, while the concentration of the total base was 0.86 M[1-2].

References

[1] I. V. Magedov. “Convenient method for the preparation of a solution of potassium bis(trimethylsilyl)amide.” Russian Chemical Bulletin 44 11 (1995): 2197–2198.
[2] J. Ahman, P. Somfai. “An Efficient Preparation of Potassium Bis (Trimethylsilyl) Amide (KHMDS).” Synthetic Communications 25 1 (1995): 2301–2303.

Potassium bis(trimethylsilyl)amide Preparation Products And Raw materials

Raw materials

Preparation Products

CYCLOHEXANE-1 4-DICARBONITRILE 98% MIXT&

Potassium bis(trimethylsilyl)amide Suppliers

Global( 279)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9639	58
airuikechemical co., ltd.	+undefined86-15315557071	sales02@sdzhonghuimaterial.com	China	983	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32957	60
Zjartschem	+86-571 87238903	jocelynpan@zjarts.com	CHINA	988	58
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29881	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	1243	58
Shandong chuangyingchemical Co., Ltd.	18853181302	sale@chuangyingchem.com	CHINA	5906	58

Supplier	Advantage
Finetech Industry Limited	58
airuikechemical co., ltd.	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
Henan Tianfu Chemical Co.,Ltd.	55
ATK CHEMICAL COMPANY LIMITED	60
Zjartschem	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
Shanghai Worldyang Chemical Co.,Ltd.	58
Shandong chuangyingchemical Co., Ltd.	58

View Lastest Price from Potassium bis(trimethylsilyl)amide manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-10-15	potassium bis(trimethylsilyl)amide 40949-94-8	US $0.00-0.00 / Kg	1Kg	99.9%	200tons	airuikechemical co., ltd.
2021-07-02	Potassium bis(trimethylsilyl)amide 40949-94-8	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd
2019-07-10	Potassium hexamethyldisilazide 40949-94-8	US $1.00 / KG	1KG	99%	25kg	Career Henan Chemical Co

potassium bis(trimethylsilyl)amide
40949-94-8
US $0.00-0.00 / Kg
99.9%
airuikechemical co., ltd.

Potassium bis(trimethylsilyl)amide
40949-94-8
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

Potassium hexamethyldisilazide
40949-94-8
US $1.00 / KG
99%
Career Henan Chemical Co

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