ChemicalBook >> CAS DataBase List >>3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate
3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate
- CAS No.
- 63540-28-3
- Chemical Name:
- 3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate
- Synonyms
- Unii-07o6708m02;Fenobam (hydrate);Fenobam [usan:inn];3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate
- CBNumber:
- CB81457036
- Molecular Formula:
- C11H13ClN4O3
- Molecular Weight:
- 0
- MDL Number:
- MOL File:
- 63540-28-3.mol
Last updated:2023-05-21 10:59:17
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO: 100 mM |
| form | A crystalline solid |
| FDA UNII | 07O6708M02 |
3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 29759 | Fenobam (hydrate) | 63540-28-3 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29759 | Fenobam (hydrate) | 63540-28-3 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 29759 | Fenobam (hydrate) | 63540-28-3 | 10mg | $153 | 2024-03-01 | Buy |
| AK Scientific | 5925EM | 1-(m-Chlorophenyl)-3-(1-methyl-4-oxo-2-imidazolin-2-yl)ureamonohydrate | 63540-28-3 | 10mg | $268 | 2021-12-16 | Buy |
3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate Chemical Properties,Uses,Production
Description
Fenobam is a noncompetitive antagonist and inverse agonist of metabotropic glutamate receptor 5 (mGluR5) that binds to an allosteric site. It inhibits intracellular calcium mobilization induced by the glutamate analog quisqualate in HEK293 cells expressing the human receptor (IC50 = 58 nM) and inhibits basal activity of mGluR5 in a cell-based assay (IC50 = 84 nM). Fenobam (10 and 30 mg/kg) reduces stress-induced hyperthermia in mice and increases drinking time in the Vogel conflict test in rats when administered at a dose of 30 mg/kg, indicating anxiolytic-like activity. It induces analgesia in the formalin test in mice when administered at a dose of 30 mg/kg.
Uses
Sedative-hypnotic.
3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate Preparation Products And Raw materials
Raw materials
Preparation Products
3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate Suppliers
Global( 5)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11217 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1248 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11974 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 19707 | 58 |
3-(3-chlorophenyl)-1-(1-methyl-4-oxo-5H-imidazol-2-yl)urea hydrate
Fenobam [usan:inn]
Unii-07o6708m02
Fenobam (hydrate)
63540-28-3