Etonogestrel
- CAS No.
- 54048-10-1
- Chemical Name:
- Etonogestrel
- Synonyms
- Nexplanon;Implanon;org3236;CS-1364;Etonoestrel;ETONOGESTREL;3-oxodesogestrel;Etonogestrel CRS;3-KETO DESOGESTREL;Etonogestrel Solution
- CBNumber:
- CB8146610
- Molecular Formula:
- C22H28O2
- Molecular Weight:
- 324.46
- MDL Number:
- MFCD00867863
- MOL File:
- 54048-10-1.mol
- MSDS File:
- SDS
| Melting point | 182-184°C |
|---|---|
| Boiling point | 473.1±45.0 °C(Predicted) |
| alpha | D +87.6° |
| Density | 1.13±0.1 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: >5mg/mL |
| pka | 13.04±0.40(Predicted) |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +80 to +95°, c = 1 (CHCl3) |
| InChI | InChI=1/C22H28O2/c1-4-21-13-14(3)20-17-9-7-16(23)12-15(17)6-8-18(20)19(21)10-11-22(21,24)5-2/h2,12,17-20,24H,3-4,6-11,13H2,1H3/t17-,18-,19-,20+,21-,22-/s3 |
| InChIKey | GCKFUYQCUCGESZ-BPIQYHPVSA-N |
| SMILES | C([C@]12CC(=C)[C@]3([H])[C@@]4([H])CCC(=O)C=C4CC[C@@]3([H])[C@]1([H])CC[C@@]2(O)C#C)C |&1:1,5,7,17,19,23,r| |
| CAS DataBase Reference | 54048-10-1(CAS DataBase Reference) |
| FDA UNII | 304GTH6RNH |
| ATC code | G03AC08 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H351-H360 |
| Precautionary statements | P201-P280-P308+P313 |
| Risk Statements | 60-40 |
| WGK Germany | 3 |
| RTECS | JF8290000 |
| HS Code | 2937230000 |
Etonogestrel price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0356 | Etonogestrel ≥98% (HPLC) | 54048-10-1 | 5mg | $116 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0356 | Etonogestrel ≥98% (HPLC) | 54048-10-1 | 25mg | $463 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHR2453 | Etonogestrel Pharmaceutical Secondary Standard; Certified Reference Material | 54048-10-1 | 200MG | $534 | 2024-03-01 | Buy |
| Sigma-Aldrich | 1173268 | Desogestrel Related Compound C United States Pharmacopeia (USP) Reference Standard | 54048-10-1 | 25MG | $1370 | 2022-05-15 | Buy |
| Cayman Chemical | 21062 | Etonogestrel ≥98% | 54048-10-1 | 1mg | $32 | 2024-03-01 | Buy |
Etonogestrel Chemical Properties,Uses,Production
Description
Etonogestrel molecule is a 3-ketodesogestrel or 19-nortestosterone which is a synthetic biologically active metabolite of progestin desogestrel. The first product including etonogestrel was developed by the Merck subsidiary Organon and FDA approved in 2001.
Chemical Properties
White Solid
Uses
A biologically active metabolite of Desogestrel.
Definition
ChEBI: Etonogestrel is a 17beta-hydroxy steroid, a 3-oxo-Delta(4) steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a female contraceptive drug.
brand name
Implanon (Organon).
General Description
Etonogestrel, 17α-13-ethyl-17hydroxy-11-methylene-18,19-dinorpregn-4-en-20-yn-3-one,3-ketodesogestrel, is the active metabolite of desogestrel. It isthe progestin component in a newer implantable contraceptive(Implanon) and in the vaginal contraceptive ring (NuvaRing).
Biochem/physiol Actions
Etonogestrel is a lipophilic molecule. Pharmacokinetics studies reveal that etonogestrel is bound to protein albumin in the blood. This remains independent of both endogenous and exogenous concentration of estradiol.
Mode of action
Etonogestrel binds to the cytoplasmic progesterone receptors in the reproductive system and subsequently activates progesterone receptor mediated gene expression. As a result of the negative feedback mechanism, luteinizing hormone (LH) release is inhibited, which leads to an inhibition of ovulation and an alteration in the cervical mucus and endometrium.
Etonogestrel Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +8615350851019 | admin@86-ss.com | China | 1001 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21628 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 904 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-86-5926051114 +8615060885618 | sales@amoychem.com | China | 6383 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Standardpharm Co. Ltd. | 86-714-3992388 | overseasales1@yongstandards.com | United States | 14332 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
View Lastest Price from Etonogestrel manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-27 | Etonogestrel
54048-10-1
|
US $50.00-123.00 / mg | 99.69% | 10g | TargetMol Chemicals Inc. | ||
 |
2025-04-27 | Etonogestrel
54048-10-1
|
US $1000.00-800.00 / kg | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2025-04-27 | Etonogestrel
54048-10-1
|
US $1.00 / g | 1g | ≥99% | 10kg/month | WUHAN FORTUNA CHEMICAL CO., LTD |
-
- Etonogestrel
54048-10-1
- US $50.00-123.00 / mg
- 99.69%
- TargetMol Chemicals Inc.
-
- Etonogestrel
54048-10-1
- US $1000.00-800.00 / kg
- 99%
- HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
-
- Etonogestrel
54048-10-1
- US $1.00 / g
- ≥99%
- WUHAN FORTUNA CHEMICAL CO., LTD