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Ampicillin sodium

Ampicillin sodium Structure
Ampicillin sodium structure
CAS No.
69-52-3
Chemical Name:
Ampicillin sodium
Synonyms
AMPICILLIN SODIUM SALT;omnipen-n;penialmen;pena/n;Alpen-n;Anhypen;Amcill-s;Citteral;Cilleral;Alppen-N
CBNumber:
CB8151850
Molecular Formula:
C16H20N3NaO4S
Molecular Weight:
373.4
MDL Number:
MFCD00064313
MOL File:
69-52-3.mol
MSDS File:
SDS
Last updated:2024-12-04 20:40:58
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Ampicillin sodium Properties

Melting point 215 °C (dec.)(lit.)
alpha +246～+272°
storage temp. 2-8°C
solubility H2O: 50 mg/mL, clear, very faintly yellow
form powder
color white with slight yellow cast
PH pH(100g/l, 25℃):8.0～10.0
Water Solubility Freely soluble in water. Sparingly soluble in acetone
BRN 4119211
InChIKey XCZQUQSOMVIRFX-AGYZSTNLNA-N
SMILES C([C@H]1C(S[C@]2([H])[C@H](NC(=O)[C@@H](C3C=CC=CC=3)N)C(=O)N12)(C)C)(=O)O.[NaH] |&1:1,4,6,10,r|
CAS DataBase Reference 69-52-3(CAS DataBase Reference)
FDA UNII JFN36L5S8K

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS08
Signal word  Danger
Hazard statements  H317-H334
Precautionary statements  P261-P272-P280-P284-P302+P352-P304+P340+P312
Hazard Codes  Xi,Xn
Risk Statements  42/43-36/37/38-22
Safety Statements  22-36/37-45-36-26
WGK Germany  2
RTECS  XH8400000
F  3-10
HS Code  29419000
Toxicity LD50 oral in rat: > 5314mg/kg

Ampicillin sodium price More Price(53)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 95586 XLD Agar suitable for microbiology, NutriSelect? Basic 69-52-3 500G $179 2024-03-01 Buy
Sigma-Aldrich 1033203 Ampicillin sodium United States Pharmacopeia (USP) Reference Standard 69-52-3 125mg $358 2024-03-01 Buy
Sigma-Aldrich 171255-M Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade - CAS 69-52-3 - Calbiochem sterile, suitable for tissue culture 69-52-3 20ml $62.2 2022-05-15 Buy
Sigma-Aldrich 171254 Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem Ampicillinsaltisanantibioticthatinhibitsbacterialcell-wallsynthesis.Ac 69-52-3 5G $82.4 2022-05-15 Buy
Sigma-Aldrich 171254 Ampicillin, Sodium Salt - CAS 69-52-3 - Calbiochem Ampicillinsaltisanantibioticthatinhibitsbacterialcell-wallsynthesis.Ac 69-52-3 25g $284 2022-05-15 Buy
Product number Packaging Price Buy
95586 500G $179 Buy
1033203 125mg $358 Buy
171255-M 20ml $62.2 Buy
171254 5G $82.4 Buy
171254 25g $284 Buy

Ampicillin sodium Chemical Properties,Uses,Production

Broad-spectrum penicillin

Ampicillin sodium is a broad-spectrum penicillin, its antibacterial spectrum is broader than penicillin , it has antibacterial activity on some gram-negative bacteria (such as Haemophilus influenzae, Escherichia coli, Proteus mirabilis) . Its effects on gram-positive cocci are similar to penicillin. Enzymatic hydrolysis of penicillin produced by bacteria may also make it inactive. It is clinically applicable in the treatment of respiratory infections, urinary tract infections, gastrointestinal tract infections, skin and soft tissue infections, meningitis, septicemia, endocarditis caused by sensitive bacteria. This product is a drug of choice for enterococcal infections.
The above information is edited by the chemicalbook of Tian Ye.

Chemical Properties

White or almost white powder or crystal. Soluble in water, slightly soluble in ethanol, insoluble in ether. Hygroscopic, when it is set at room temperature in an aqueous solution ,it gradually turns yellow,produces turbidity, decreases potency. Odorless, slightly bitter taste.

Uses

A semi-synthetic broad-spectrum penicillin,it is mainly used for treatment of penicillin-sensitive gram-positive bacteria, Escherichia coli, Proteus, Salmonella, Shigella and other.

production method

It is derived from the ampicillin salifying : Ampicillin is suspended in water, adjust to pH 9 with sodium hydroxide solution, dissolve and filter . The filtrate is added active carbon, and is filtered and the filtrate is dried at a low temperature, to obtain the product.

Category

Toxic substances

Toxicity grading

Low toxic

Acute toxicity

Oral-rat LD50:> 5314 mg/kg; Oral-Mouse LD50:> 5314 mg/kg.

Flammability and hazard characteristics

Combustion produces toxic sodium oxide, nitrogen oxide and sulfur oxide gases.

Storage Characteristics

Ventilated, low-temperature ,dry storeroom.

Extinguishing agent

Water, dry powder, foam, sand.

Chemical Properties

White or almost white powder, hygroscopic.

Uses

Penicillin antibacterial.

Uses

Ampicillin sodium salt is a reagent for transformed cells expressing beta-lactamase. It acts as a structural analogue of acyl-D-alanyl-D-alanine, acylates the transpeptidase enzyme and prevents the cross-linking of the peptidoglycan of the cell wall necessary for the growth of the bacterium.

Uses

diuretic, anti-hypertensive

Definition

ChEBI: Ampicillin sodium is an organic sodium salt. It contains an ampicillin(1-).

brand name

Polycillin-N (Bristol-Myers Squibb).

General Description

Chemical structure: ?-lactam

Biological Activity

ampicillin sodium is a competitive inhibitor of the enzyme transpeptidase with ic50 value of 1.8 μg/ml [1].ampicillin is a β-lactam antibiotic that kills bacteria by inhibiting transpeptidase reactions. transpeptidase is involved in the final stages of cell wall biosynthesis and inhibition of it ultimately leads to cell lysis [1].in e. coli 146 cells treated with ether, ampicillin showed no significant inhibition on the transpeptidase reaction at concentrations below 0.5 μg/ml, but exhibited 50% inhibition at the concentration of 1.8 μg/ml. in e. coli 146 cells, the minimal inhibitory concentration (mic) of ampicillin was 3.1 μg/ml [1]. in e. coli and s. typhi, ampicillin and epicillin at concentrations close to mic values killed bacteria at slower rates than amoxycillin [2].in experimental mouse infections, oral or subcutaneous treatment of ampicillin at the dose of 0.2 ml/20 g was significantly more effective than epicillin and amoxycillin against the majority of infections [2].[1]. moore b a, jevons s, brammer k w. inhibition of transpeptidase activity in escherichia coli by thienamycin. antimicrobial agents and chemotherapy, 1979, 15(6): 831-833.[2]. basker m j, gwynn m n, white a r. comparative activities of ampicillin, epicillin and amoxycillin in vitro and in vivo. chemotherapy, 1979, 25(3): 170-180.

Contact allergens

Ampicillin caused contact dermatitis in a nurse also sensitized to amoxicillin (with tolerance to oral phenoxymethylpenicillin) and in a pharmaceutical factory worker. Systemic drug reactions are common. Crossreactivity is regular with ampicillin and can occur with other penicillins.

Biochem/physiol Actions

Mode of Action: This is a ?-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane. Mode of Resistance: Administration with ?-lactamase cleaves the ?-lactam ring of Ampicillin and inactivates it. Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Safety Profile

Moderately toxic by intraperitoneal route. Human systemic effects by ingestion: hypermotility, diarrhea, and other gastrointestinal changes. Questionable carcinogen. When heated to decomposition it emits very toxic fumes of NOx, Na2O, and SOx.

storage

+4°C

Ampicillin sodium Preparation Products And Raw materials

Raw materials

2-Ethylhexanoic acid Ethyl acetate Sodium hydroxide Isopropyl alcohol

Preparation Products

Ampicillin sodium Suppliers

Global( 626)Suppliers
Supplier Tel Email Country ProdList Advantage
Aladdin Scientific
+1-+1(833)-552-7181 sales@aladdinsci.com United States 57505 58
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085 abby@weibangbio.com China 8810 58
Hebei Yime New Material Technology Co., Ltd. 		+86-66697723 +86-17703311139 admin@china-yime.com China 563 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850 info@fortunachem.com China 5976 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325 sales1@chuanghaibio.com China 5892 58
Hebei Weibang Biotechnology Co., Ltd 		+8617732866630 bess@weibangbio.com China 18153 58
shandong perfect biotechnology co.ltd 		+86-53169958659 +86-13153181156 sales@sdperfect.com China 294 58
Guangzhou Tengyue Chemical Co., Ltd. 		+86-86-18148706580 +8618826483838 evan@tyvovo.com China 148 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649 sarah@tnjone.com China 1143 58
Apeloa production Co.,Limited 		+8619933239880 admin@apcl.com.cn China 852 58
Supplier Advantage
Aladdin Scientific
58
Hebei Weibang Biotechnology Co., Ltd 		58
Hebei Yime New Material Technology Co., Ltd. 		58
Wuhan Fortuna Chemical Co., Ltd 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Hebei Weibang Biotechnology Co., Ltd 		58
shandong perfect biotechnology co.ltd 		58
Guangzhou Tengyue Chemical Co., Ltd. 		58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		58
Apeloa production Co.,Limited 		58

View Lastest Price from Ampicillin sodium manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ampicillin Sodium pictures 2024-12-04 Ampicillin Sodium
69-52-3
 US $150.00 / kg 1kg 99% 500kg Hebei Zhuanglai Chemical Trading Co Ltd
Ampicillin sodium pictures 2024-12-04 Ampicillin sodium
69-52-3
 US $0.00 / kg 25kg ≥85% 10tons Henan Suikang Pharmaceutical Co.,Ltd.
Ampicillin sodium pictures 2024-11-29 Ampicillin sodium
69-52-3
 US $0.00 / Kg/Bag 5KG 845-988μg/mg; Sterile; USP 1000KGS WUHAN FORTUNA CHEMICAL CO., LTD
  • Ampicillin sodium pictures
  • Ampicillin sodium
    69-52-3
  • US $0.00 / Kg/Bag
  • 845-988μg/mg; Sterile; USP
  • WUHAN FORTUNA CHEMICAL CO., LTD

Ampicillin sodium Spectrum

Ampicillin sodium(69-52-3)MSAmpicillin sodium(69-52-3)RamanAmpicillin sodium(69-52-3)IR

69-52-3(Ampicillin sodium)Related Search:

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D-6-(-Amino-phenylacetamido)penicillanicacidsodiumsalt Domicillin pena/n penbritin-s polycillin-n principen/n sodiumamipicillin sodiumbinotal sodiumd-(-)-alpha-aminobenzylpenicillin sodiump-50 sodiumsalt,d-(-)-do)-3-dimethyl-7-oxo- Alpen-n Amcill-s Binotalsodium Citteral AMPICILLIN SODIUM SALT, PHARMA AMPICILLIN SODIUM SALT USP AMPICILLIN SODIUM USP(CRM STANDARD) AMPICILLIN SODIUM WHO(CRM STANDARD) AMPICILLINE SODIUM SALT BIOTECH AmpicillinSodiumSterilePowder 4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-(2R)-aminophenylacetylamino-3,3-dimethyl-7-oxo-, monosodium salt, (2S,5R,6R)- 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-, monosodium salt, D-(-)- (8CI) 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[(aminophenylacetyl)amino]-3,3-dimethyl-7-oxo-, monosodium salt, [2S-[2α,5α,6β(S*)]]- Anhypen Britapen injection Cilleral Monosodium ampicillin Sodium 6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Sodium 6-[D-α-aminophenylacetamido]penicillanoate Sodium ampicillinate Sodium D-α-aminobenzylpenicillanate 6-(2-amino-2-phenylacetamido)- 3,3-dimethyl-7-oxo-, sodium salt, d-(-)-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(2-amino-2-phenylacetamido)- 3,3-dimethyl-7-oxo-, sodium salt, D-(-) Alppen-N Amicill-S Sodium [2S-[2α,5α,6β(S*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate Sodium ampicillin AMPICILLIN SODIUM SALT, PURE 98% MIN. CSL Austrapen Composition (Ampicillin sodium) ampicillin sodium soluble powder AMpicilllin sodiuM salt CITRIC ACID 3NA SALT 2H2O REAGENT GR Ampicillin sodium salt, >=98.5% AMMONIUM ACETATE ULTRA PURE GRADE Ampicillin sodium salt, cell culture grade Ampicillin Sodium Salt, Antibiotic for Culture Media Use Only )-α-Aminobenzylpenicillin sodium salt Ampicillin sodium salt Ampicillin, Sodium Salt, Sterile, Tissue Culture Grade Ampicillin, Sodium Salt, Sterile-Filtered Aqueous Solution, Cell Culture Tested 6-(2-amino-2-phenylacetamido)-3,3-dimethyl-7-oxo-,sodiumsalt,d-(-)-4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylicacid XLD AGAR sodium [2s-[2alpha,5alpha,6beta(s*)]]-6-(aminophenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate D(-)-ALPHA-AMINOBENZYLPENICILLIN SODIUM SALT AMPICILLIN, SODIUM SALT, GAMMA IRRADIATED AMPICILLIN NA-SALT Ampicillin Na D-(?)-α-Aminobenzylpenicillin sodium salt