Anti-PFN1
- CAS No.
- Chemical Name:
- Anti-PFN1
- Synonyms
- Anti-PFN1;Monoclonal Anti-Profilin 1 antibody produced in mouse;Anti-Profilin 1 (C-terminal) antibody produced in rabbit;Anti-Profilin 1 (N-terminal) antibody produced in rabbit
- CBNumber:
- CB82093600
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD09265368
- MOL File:
- Mol file
Anti-PFN1 price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | P7749 | Anti-Profilin 1 (N-terminal) antibody produced in rabbit ~1?mg/mL, affinity isolated antibody, buffered aqueous solution | 200μL | $648 | 2024-03-01 | Buy | |
Sigma-Aldrich | P7624 | Anti-Profilin 1 (C-terminal) antibody produced in rabbit ~1?mg/mL, affinity isolated antibody, buffered aqueous solution | 200μL | $209.6 | 2024-03-01 | Buy |
Anti-PFN1 Chemical Properties,Uses,Production
Uses
Anti-Profilin 1 (N-terminal) antibody produced in rabbit has been used in immunoblotting and immunofluorescence.
General Description
Anti-Profilin 1 (N-terminal) is developed in rabbit using as immunogen a synthetic peptide corresponding to amino acid residues of human profilin 1, conjugated to keyhole limpet hemocyanin (KLH). Profilin 1 is a ubiquitous actin monomer-binding protein. Profilin 1 is highly expressed throughout development and adulthood in most of the tissues including brain.
Biochem/physiol Actions
Profilin 1 is involved in actin polymerization in response to extracellular signals. Profilins were shown to be important for normal cell proliferation, differentiation and motility. Deletion of profilin 1 gene leads to an embryonic lethal phenotype. Profilin 1 is a potent regulator of actin filament dynamics. Although profilin 1 prevents spontaneous actin polymerization by complexing with unpolymerized actin in vivo, actin-profilin complexes can be added to free barbed ends, thereby stimulating actin polymerization. Profilin 1 was suggested to act as a tumor suppressor protein based on its reduced expression in several types of invasive cancers and its ability to suppress tumorigenicity when over-expressed in breast cancer cells. Deletion of profilin 1 is associated with Miller-Dieker syndrome.
Anti-PFN1 Preparation Products And Raw materials
Raw materials
Preparation Products
Anti-PFN1 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
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Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Supplier | Advantage |
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Sigma-Aldrich | 80 |