ChemicalBook >> CAS DataBase List >>Atrasentan hydrochloride
Atrasentan hydrochloride
- CAS No.
- 195733-43-8
- Chemical Name:
- Atrasentan hydrochloride
- Synonyms
- ABT627;ABT-627;ABT 627;A 147627.1;Abbott 147627;Atrasentan HCl;Unii-E4G31X93za;ABT-627 hydrochloride;A-147627 hydrochloride;Atrasentan hydrochloride
- CBNumber:
- CB82128704
- Molecular Formula:
- C29H38N2O6.HCl
- Molecular Weight:
- 547.08
- MDL Number:
- MFCD13194884
- MOL File:
- 195733-43-8.mol
Last updated:2024-11-19 23:02:33
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
|---|---|
| solubility | Soluble in DMSO |
| form | Powder |
| color | Off-white to gray |
| InChIKey | IJFUJIFSUKPWCZ-FZVADPAUNA-N |
| SMILES | C1(=CC2=C(OCO2)C=C1)[C@@H]1[C@@H](C(=O)O)[C@H](C2C=CC(OC)=CC=2)N(CC(N(CCCC)CCCC)=O)C1.Cl |&1:9,10,14,r| |
| FDA UNII | E4G31X93ZA |
| NCI Drug Dictionary | atrasentan hydrochloride |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
Atrasentan hydrochloride price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | A793930 | AtrasentanHydrochloride | 195733-43-8 | 25mg | $825 | 2021-12-16 | Buy |
| AK Scientific | 0895CB | Atrasentanhydrochloride | 195733-43-8 | 50mg | $937 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FA64949 | Atrasentan hydrochloride | 195733-43-8 | 100mg | $1010 | 2021-12-16 | Buy |
| ChemScene | CS-1373 | Atrasentan(hydrochloride) 99.51% | 195733-43-8 | 50mg | $1087 | 2021-12-16 | Buy |
| AK Scientific | 0895CB | Atrasentanhydrochloride | 195733-43-8 | 5mg | $277 | 2021-12-16 | Buy |
Atrasentan hydrochloride Chemical Properties,Uses,Production
Description
Atrasentan Hydrochloride is the orally available hydrochloride salt of pyrrolidine-3-carboxylic acid with potential antineoplastic activity. As a selective antagonist of the endothelin-A (ETA) receptor, atrasentan binds selectively to the ETA receptor, which may result in inhibition of endothelin-induced angiogenesis and tumor cell proliferation.
Uses
Atrasentan belongs to a pyrrolidine and benzodioxole derivative. It is a selective antagonist of the endothelin-A (ETA) receptor and binds selectively to the ETA receptor, which may result in the inhibition of endothelin-induced angiogenesis and tumor cell proliferation. Its potential therapeutic uses include the treatment of diabetic nephropathies and as an antineoplastic agent.
Biological Activity
Atrasentan is a selective endothelin ETA receptor antagonist with an IC50 of 0.2 nM for ETA compared to 190 nM for ETB receptors. It blocks blocks endothelin induced cell proliferation, and has been investigated as a possible treatment for prostate cancer, and more recently for therapy for diabetic kidney disease.
Atrasentan hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Atrasentan hydrochloride Suppliers
Global( 74)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Xi'an ZB Biotech Co.,Ltd | sales03@xazbbio.com | CHINA | 719 | 58 | |
| Wuhan Ruilida Biomedical Technology Co., Ltd. | 18201884268 | magean83@163.com | China | 1506 | 58 |
View Lastest Price from Atrasentan hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | Atrasentan hydrochloride
195733-43-8
|
US $58.00-167.00 / mg | 98.64% | 10g | TargetMol Chemicals Inc. |
-
- Atrasentan hydrochloride
195733-43-8
- US $58.00-167.00 / mg
- 98.64%
- TargetMol Chemicals Inc.
195733-43-8(Atrasentan hydrochloride)Related Search:
Atrasentan hydrochloride
3-Pyrrolidinecarboxylic acid, 4-(1,3-benzodioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)-, monohydrochloride, (2R,3R,4S)-
A 147627.1
Abbott 147627
Atrasentan HCl
Atrasentan hydrochloride [usan]
Unii-E4G31X93za
ABT 627
ABT627
ABT-627
3-Pyrrolidinecarboxylicacid,4-(1,3-benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)-,hydrochloride (1:1), (2R,3R,4S)-
(2R,3R,4S)-4-(1,3-Benzodioxol-5-yl)-1-[2-(dibutylamino)-2-oxoethyl]-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
(2R,3R,4S)-4-(Benzo[d][1,3]dioxol-5-yl)-1-(2-(dibutylamino)-2-oxoethyl)-2-(4-methoxyphenyl)pyrrolidine-3-carboxylic acid hydrochloride
Atrasentan hydrochloride, CID 159595
ABT-627; ABT627; ABT 627; ABBOTT 147627
Atrasentan hydrochloride (ABT-627
ABT-627; ABT627; ABT 627
ABT-627 hydrochloride
(+)-A 127722 hydrochloride
A-147627 hydrochloride
Atrasentan Hydrochloride，ABT627 HCl
A 147627,A-147627,(+)-A 127722,Atrasentan hydrochloride,Atrasentan,ABT627,ABT-627,Endothelin Receptor,ABT 627,Inhibitor,inhibit,A147627
195733-43-8
C29H38N2O6HCl
C29H39ClN2O6
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