Cefotetan disodium
- CAS No.
- 74356-00-6
- Chemical Name:
- Cefotetan disodium
- Synonyms
- Cefotan in plastic container;Cefotetan and dextrose in duplex container;Cefotetan disodi;CEFOTETAN DISODIUM;Ondansetron Impurity 14;Cefotetan DisodiuM Sterile;Cefotetan Sodium (ICI156834;Cefotetan disodium USP/EP/BP;Disodium (7R)-7-[[4-(carbamoyl-carboxylato-methylidene)-1,3-dithietane-2-carbonyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,7-[[[4-(2-aMino-1-carboxy-2-oxoethylidene)-1,3-dithietan-2-yl]carbonyl]aMino]-7-Methoxy-3-[[(1-Methyl-1H-tetrazol-5-yl)thio]Methyl]-8-oxo-,sodiuM salt (1:2), (6R,7S)-
- CBNumber:
- CB82130367
- Molecular Formula:
- C17H18N7NaO8S4
- Molecular Weight:
- 599.6
- MDL Number:
- MFCD00941449
- MOL File:
- 74356-00-6.mol
| Boiling point | 798℃ |
|---|---|
| RTECS | XI0330600 |
| storage temp. | 2-8°C |
| solubility | Freely soluble in aqueous solution |
| form | powder |
| FDA UNII | 0GXP746VXB |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H334 |
| Precautionary statements | P261-P280g-P284-P304+P340-P342+P311a-P501a |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| HS Code | 29419000 |
| Toxicity | LD50 in male mice, rats (g/kg): 6.35, 8.48 i.v.; 8.12, 8.37 i.p.; >10 orally and s.c. both species (Imamura) |
Cefotetan disodium price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A5737 | Cefotetan disodium | 74356-00-6 | 100mg | $47.6 | 2024-03-01 | Buy |
| Alfa Aesar | J66206 | Cefotetan disodium | 74356-00-6 | 100mg | $89.65 | 2024-03-01 | Buy |
| Cayman Chemical | 23624 | Cefotetan (sodium salt) ≥98% | 74356-00-6 | 50mg | $64 | 2024-03-01 | Buy |
| Cayman Chemical | 23624 | Cefotetan (sodium salt) ≥98% | 74356-00-6 | 100mg | $101 | 2024-03-01 | Buy |
| Cayman Chemical | 23624 | Cefotetan (sodium salt) ≥98% | 74356-00-6 | 250mg | $236 | 2024-03-01 | Buy |
Cefotetan disodium Chemical Properties,Uses,Production
Brand Name(s) in US
Cefotan
Description
Cefotetan disodium is a β-lactamase resistant, second generation cephalosporin with a serum half-life of about three hours, permitting twice-daily dosing.
Originator
Yamanouchi (Japan)
Uses
Antibacterial.
Uses
Cefotetan Disodium is a related compound of Cefotetan (C242970), an antibiotic related to Cephalosporin that is used to treat bacterial infections.
Definition
ChEBI: The disodium salt of cefotetan.
brand name
Cefotan (AstraZeneca);YAMATETAN.
Clinical Use
Cefotetan (Cefotan) is a third-generation cephalosporin thatis structurally similar to cefoxitin. Like cefoxitin, cefotetanis resistant to destruction by β-lactamases. It is also a competitiveinhibitor of many β-lactamases and causes transient inactivation of some of these enzymes. Cefotetan is reportedto synergize with β-lactamase–sensitive β-lactams but, unlikecefoxitin, does not appear to cause antagonism.
The antibacterial spectrum of cefotetan closely resemblesthat of cefoxitin. It is, however, generally more activeagainst S. aureus, and members of the Enterobacteriaceaefamily sensitive to both agents. It also exhibits excellentpotency against H. influenzae and N. gonorrhoeae, includingβ-lactamase–producing strains. Cefotetan is slightly lessactive than cefoxitin against B. fragilis and other anaerobes.Enterobacter spp. are generally resistant to cefotetan, andthe drug is without effect against Pseudomonas spp.Cefotetan has a relatively long half-life of about 3.5hours. It is administered on a twice-daily dosing schedule. Itis excreted largely unchanged in the urine. Aqueoussolutions for parenteral administration maintain potency for24 hours at 25°C. Refrigerated solutions are stable for 4 days.
Cefotetan contains the MTT group that has been associatedwith hypoprothrombinemia and alcohol intolerance.Another cephalosporin that lacks these properties should beselected for patients at risk for severe bleeding or alcoholism.
Veterinary Drugs and Treatments
Cefotetan may be a reasonable choice for treating serious infections caused by susceptible bacteria, including E. coli or anaerobes. It appears to be well tolerated in small animals and may be given less frequently than cefoxitin.
Cefotetan disodium Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29811 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | info@fortunachem.com | China | 5978 | 58 |
| Baoji Guokang Healthchem co.,ltd | +8615604608665 15604608665 | dominicguo@gk-bio.com | CHINA | 9414 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
View Lastest Price from Cefotetan disodium manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-27 | Cefotetan disodium
74356-00-6
|
US $0.00 / Kg/Bag | 1KG | 98%min | 500kg | WUHAN FORTUNA CHEMICAL CO., LTD | |
 |
2024-10-24 | Cefotetan disodium
74356-00-6
|
US $160.00-590.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2020-05-25 | Cefotetan disodium
74356-00-6
|
US $0.00-0.00 / Kg | 1KG | 99.0%+ | 300 MT | Shaanxi Dideu Medichem Co. Ltd |
-
- Cefotetan disodium
74356-00-6
- US $0.00 / Kg/Bag
- 98%min
- WUHAN FORTUNA CHEMICAL CO., LTD
-
- Cefotetan disodium
74356-00-6
- US $160.00-590.00 / mg
- TargetMol Chemicals Inc.
-
- Cefotetan disodium
74356-00-6
- US $0.00-0.00 / Kg
- 99.0%+
- Shaanxi Dideu Medichem Co. Ltd