NORTRIPTYLINE HYDROCHLORIDE

NORTRIPTYLINE HYDROCHLORIDE Properties

Melting point	217-220?C
Flash point	9℃
storage temp.	2-8°C
solubility	ethanol: 100 mg/mL
form	powder
color	white to off-white
λmax	237nm(H2O)(lit.)
Merck	14,6715
NCI Dictionary of Cancer Terms	Pamelor
FDA UNII	00FN6IH15D

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P301+P312+P330
Hazard Codes	Xn,T,F
Risk Statements	22-36/38-23/25-11-39/23/24/25-23/24/25
Safety Statements	22-36-45-24-16-7-36/37
RIDADR	UN 1230 3/PG 2
WGK Germany	3
RTECS	HP0175000
HS Code	2921490002
Toxicity	LD50 oral in rat: 405mg/kg

NORTRIPTYLINE HYDROCHLORIDE price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	PHR3216	Nortriptyline Hydrochloride pharmaceutical secondary standard, certified reference material	894-71-3	500MG	$230	2024-03-01	Buy
Sigma-Aldrich	N-907	Nortriptyline hydrochloride solution 1.0?mg/mL in methanol (as free base), ampule of 1?mL, certified reference material, Cerilliant?	894-71-3	1mL	$27.7	2024-03-01	Buy
Sigma-Aldrich	N7261	Nortriptyline hydrochloride ≥98% (TLC), powder	894-71-3	10g	$80.2	2024-03-01	Buy
Sigma-Aldrich	1474005	Nortriptyline hydrochloride United States Pharmacopeia (USP) Reference Standard	894-71-3	200mg	$436	2024-03-01	Buy
TCI Chemical	N0957	Nortriptyline Hydrochloride >98.0%(HPLC)(T)	894-71-3	5g	$34	2024-03-01	Buy

Product number	Packaging	Price	Buy
PHR3216	500MG	$230	Buy
N-907	1mL	$27.7	Buy
N7261	10g	$80.2	Buy
1474005	200mg	$436	Buy
N0957	5g	$34	Buy

NORTRIPTYLINE HYDROCHLORIDE Chemical Properties,Uses,Production

Chemical Properties

Off-White Solid

Originator

Aventyl,Lilly,UK,1963

Uses

Nortriptyline Hydrochloride (Amitriptyline EP Impurity C) is a tricyclic antidepressant.

Uses

Monoamine reuptake inhibitor; tricyclic antidepressant.

Definition

ChEBI: Nortriptyline hydrochloride is an organic tricyclic compound. It has a role as a geroprotector.

Manufacturing Process

A mixture of 114.5 g of 5-(3-chloropropylidene)dibenzo[a,d]cyclohepta[1,4] diene, 75 ml of benzene, and about 400 ml of methylamine is heated in an autoclave at 120°C for six hours. The excess methylamine is distilled from the reaction mixture under vacuum and the residue is stirred with 300 ml of water. Acidification of the mixture with hydrochloric acid causes the separation of the hydrochloride of 5-(3-methylaminopropylidene)dibenzo[a,d] cyclohepta[1,4]diene. The product is collected by filtration and is purified by recrystallization from a mixture of absolute ethanol and ethyl acetate. MP 210°C to 212°C.

brand name

Aventyl Hydrochloride (Lilly); Aventyl Hydrochloride (Ranbaxy); Pamelor (Tyco).

Therapeutic Function

Antidepressant

General Description

Pertinent biological and chemical properties for nortriptyline,3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)Nmethyl-1-propanamine hydrochloride, 5-(3-methyl-aminopropylidene)-10,11-hydro-5H-dibenzo[a,d] cycloheptene hydrochloride(Aventyl, Pamelor), are given previously in thediscussion of amitriptyline. Metabolic inactivation and eliminationare like those of amitriptyline. Nortriptyline is a selectiveNE transporter (NET) inhibitor.

Biological Activity

ki: 3.4 nm: blocks the norepinephrine transporter.ki: 161 nm: inhibits the serotonin transporter.nortriptyline, a dibenzocycloheptene-derivative tricyclic antidepressant, inhibits norepinephrine and serotonin transporters, which is used for short-term treatment of various forms of depression, including major depression, dysthymia, and atypical depressions. nortriptyline suppresses the norepinephrine presynaptic receptors, thus inhibiting the reuptake of this neurotransmitter and increasing the concentration in the synaptic cleft in the central nervous system.norepinephrine transporter is responsible for the sodium-chloride (na+/cl-) -dependent reuptake of extracellular norepinephrine. serotonin transporter transports serotonin from the synaptic cleft to the presynaptic neuron.

Biochem/physiol Actions

Tricyclic antidepressant that is a more potent inhibitor of the norepinephrine transporter (Ki = 3.4 nM) than the serotonin transporter (Ki = 161 nM). 5-HT2 serotonin receptor antagonist.

in vitro

nortriptyline dose-dependently dampened the spontaneous migration of human polymorphonuclear cells (pmn) at the highest concentrations (10-4 and 10-5 m). nortriptyline decreased the motility of the cells at 10-4m. chemotaxis of pmn triggered by 10-10m n-formyl-l-methionil-l-leucyl-l-phenylalanine (fmlp) was blocked by nortriptyline in a dose-dependent fashion [1].

in vivo

rats and mice were injected intraperitoneally with nortriptyline at the dose of 50, 25, 12.5 mg/kg. after 2 hours of the last injection, nortriptyline inducted little or no inhibition of the 4, α-dimethyl-meta-tyramine (h 77/77) induced depletion in a dose of 25 + 12.5 mg/kg. however, there was a partial blockade, evoked by nortriptyline in a dose of 50 + 25 mg/kg, of the h 77/77 elicited depletion in the noradrenaline nerve terminals in all the rats studied. additionally, nortriptyline also proved to be active in the brain, however, its activity was low [2].

References

[1]. sacerdote, p., bianchi, m., & panerai, a. chlorimipramine and nortriptyline but not fluoxetine and fluvoxamine inhibit human polymorphonuclear cell chemotaxis in vitro. general pharmacology: the vascular system. 1994; 25(3): 409-412.
[2]. carlsson, a., corrodi, h., fuxe, k., & hkfelt, t. effects of some antidepressant drugs on the depletion of intraneuronal brain catecholamine stores caused by 4, α-dimethyl-meta-tyramine. european journal of pharmacology.1969; 5(4): 367-373.

NORTRIPTYLINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Methylamine

Preparation Products

NORTRIPTYLINE HYDROCHLORIDE Suppliers

Global( 240)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29811	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32165	58
Xi'an MC Biotech, Co., Ltd.	029-89275612 +8618991951683	mcbio_sales@163.com	China	2251	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15352	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9980	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38632	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33338	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58

Supplier	Advantage
career henan chemical co	58
TargetMol Chemicals Inc.	58
Xi'an MC Biotech, Co., Ltd.	58
AFINE CHEMICALS LIMITED	58
NewCan Biotech Limited	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
LEAPCHEM CO., LTD.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

View Lastest Price from NORTRIPTYLINE HYDROCHLORIDE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2024-11-19	Nortriptyline hydrochloride 894-71-3	US $33.00-68.00 / mg		≥95%	10g	TargetMol Chemicals Inc.
2024-11-19	Nortriptyline hydrochloride 894-71-3	US $33.00-68.00 / mg		≥95%	10g	TargetMol Chemicals Inc.
2019-12-25	NORTRIPTYLINE HYDROCHLORIDE 894-71-3	US $1.00 / g	1g	99%	1000KGS	Career Henan Chemical Co

Nortriptyline hydrochloride
894-71-3
US $33.00-68.00 / mg
≥95%
TargetMol Chemicals Inc.

Nortriptyline hydrochloride
894-71-3
US $33.00-68.00 / mg
≥95%
TargetMol Chemicals Inc.

NORTRIPTYLINE HYDROCHLORIDE
894-71-3
US $1.00 / g
99%
Career Henan Chemical Co

NORTRIPTYLINE HYDROCHLORIDE Spectrum

NORTRIPTYLINE HYDROCHLORIDE(894-71-3)¹HNMR

894-71-3(NORTRIPTYLINE HYDROCHLORIDE)Related Search:

Amitriptyline trans-10-Hydroxy Nortriptyline NORTRIPTYLINE NORTRIPTYLINE HYDROCHLORIDE Amitriptyline hydrochloride

10-hydroxyamitriptyline AMITRIPTYLINE-D3 HCL (N-METHYL-D3) DIBENZOSUBEROL Cyclobenzaprine hydrochloride amitriptyline N-oxide

Dibenzosuberone DIBENZOSUBERENOL 5-(3-DIMETHYLAMINOPROPYL)-10,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-OL AMITRIPTYLINE HCL (D6) 10,11-DIHYDRO-5 H-DIBENZO[A,D]CYCLOHEPTENE

NORTRIPTYLINE-D3 HYDROCHLORIDE Piroheptine amitriptyline N-glucuronide

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Nortriptyline Hydrochloride (200 mg) Nortriptyline HCl, 1.0 mg/mL as free base Norzepine Sensival Vividyl NORTRIPTYLINE HCL(P) Norfenazin Nortriptyline hydrochloride solution Nortriptyline for system suitability 1-Propanamine, 3-(10,11-dihydro-5H-dibenzoa,dcyclohepten-5-ylidene)-N-methyl-, hydrochloride NORTRIPTYLINEHYDROCHLORIDE,USP NORTRIPTYLINE HCL USP Nortriptyline solution hydrochloride 3-(10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5-ylidene)-n-methyl-1-propanamin 5-(3-(methylamino)propylidene)dibenzo(a,e)cyclohepta(1,5)dienehydrochloride NORTRIPTYLINE HYDROCHLORIDE NORTRIPTYLINE HCL 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N-methylpropylamine hydrochloride 3-(10,11-Dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N-methyl-1-propanamine·hydrochloride Nortrityline Hydrochloride (2)10,11-Dihydro-N-methyl-5H-dibenzo[A,D]cycloheptene-.delta.5.gamma.-propylamine, hydrochloride 5-[(3-(Methylamino)propylidene]-10,11-dihydro-5H-dibenzo[A,D]cycloheptene hydrochloride 5-[3-(Methylamino)propylidene]dibenzo[A,D]cyclohepta[1,5]diene hydrochloride 5H-Dibenzo[A,D]cycloheptene-.delta.(sup5),.gamma.-propylamine, 10-11-dihydro-N-methyl-, hydrochloride 5H-Dibenzo[A,D]cycloheptene-.delta.5,.gamma.-propylamine, 10,11-dihydro-N-methyl-, hydrochloride Acetexa Noramitriptyline hydrochloride nortriptyline hydrochloride methanol*solution 5-(3-methylaminopropylidene)-10,11-dihydro-5h-dibenzo(a,d)cycloheptenehydroc 5h-dibenzo(a,d)cycloheptene-delta(sup5),gamma-propylamine,10-11-dihydro-n-met aventylallegron aventylhydrochloride desmethylamitriptylinehydrochloride nortrilen pamelor AMITRIPTYLINE HYDROCHLORIDE IMP C 3-(10, 11-DIHYDRO-5H-DIBENZO[A,D]-CYCLOHEPTEN-5-YLIDENE)-N-METHYL-1-PROPANAMINE HYDROCHLORIDE Amitriptyline hydrochloride impurity C Amitriptyline EP Impurity C HCl Nortriptyline hydrochloride CRS Nortriptyline Hydrochloride > Nortriptyline for system suitability CRS Nortriptyline HCl (Amitriptyline EP Impurity C HCl) Amitriptyline EP Impurity C HCl (Nortriptyline HCl) Desitriptyline HCl ELF-101 hydrochloride EN-7048 hydrochloride 3-(10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N-methylpropan-1-amine hydrochloride 10,11-Dihydro-5-(N-methyl-3-aminopropylidene)-5H-dibenzo[a,d]cycloheptene Hydrochloride NORTRIPTYLINE HCL(USP)(COMING SOON)(P) USP/EP/BP NORTRIPTYLINE HYDROCHLORIDE USP/EP/BP Nortriptyline HydrochlorideQ: What is Nortriptyline Hydrochloride Q: What is the CAS Number of Nortriptyline Hydrochloride Q: What is the storage condition of Nortriptyline Hydrochloride Q: What are the applications of Nortriptyline Hydrochloride Amitriptyline Impurity 3 Nortriptyline Hydrochloride (1474005) N-Desmethyl Amitriptyline HCl Amitriptyline Hydrochloride EP Impurity C as Hydrochloride Nortriptyline hydrochloride in methanol 894-71-3