Bucladesine sodium
- CAS No.
- 16980-89-5
- Chemical Name:
- Bucladesine sodium
- Synonyms
- DC 2797;,5ÕDBcAMP-Na;N6-2ÕPrestwick_32;CAMP, DB-, NA;BUCLADESINE NA;dt5621sodiumsalt;DIB-3:5-CAMP, NA;bucladesinesodium
- CBNumber:
- CB8236166
- Molecular Formula:
- C18H25N5NaO8P
- Molecular Weight:
- 493.39
- MDL Number:
- MFCD00005843
- MOL File:
- 16980-89-5.mol
- MSDS File:
- SDS
Melting point | >173°C (dec.) |
---|---|
storage temp. | -20°C |
solubility | H2O: 50 mg/mL |
form | powder |
color | white |
Merck | 14,1463 |
Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
InChIKey | DBXVIQJWMFGXGO-AOTDUVMNNA-N |
SMILES | O([C@@H]1[C@]2([H])OP(O)(=O)OC[C@@]2([H])O[C@H]1N1C=NC2C(=NC=NC1=2)NC(=O)CCC)C(=O)CCC.[NaH] |&1:1,2,10,13,r| |
FDA UNII | 4DZN2C97A7 |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
Safety Statements | 24/25 |
WGK Germany | 2 |
RTECS | ES5055500 |
F | 10-21 |
HS Code | 29349990 |
Bucladesine sodium price More Price(50)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 28745-M | Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA. | 16980-89-5 | 25mg | $136 | 2024-03-01 | Buy |
Sigma-Aldrich | 28745-M | Adenosine 3ʹ,5ʹ-cyclic Monophosphate, N⁶,O2ʹ-Dibutyryl-, Sodium Salt - CAS 16980-89-5 - Calbiochem This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA. | 16980-89-5 | 100mg | $418 | 2024-03-01 | Buy |
Sigma-Aldrich | 28745-M | Adenosine 3′,5′-cyclic Monophosphate, N⁶,O2′-Dibutyryl-, Sodium Salt This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA. | 16980-89-5 | 1g | $1250 | 2024-03-01 | Buy |
Sigma-Aldrich | 28745-M | Adenosine 3′,5′-cyclic Monophosphate, N⁶,O2′-Dibutyryl-, Sodium Salt This Dibutyryl-cAMP, CAS 16980-89-5, is a cell-permeable cAMP analog that preferentially activates PKA. | 16980-89-5 | 28745-1GM | $1220 | 2023-06-20 | Buy |
TCI Chemical | D4228 | N6,2'-O-Dibutyryladenosine 3',5'-Cyclic Monophosphate Sodium Salt >97.0%(HPLC) | 16980-89-5 | 25mg | $121 | 2024-03-01 | Buy |
Bucladesine sodium Chemical Properties,Uses,Production
Description
Bucladesine sodium is a derivative of cyclic-AMP with cardiac stimulant and peripheral vasodilatory properties. It is reported to be useful in cardiac insufficiency, especially after heart surgery.
Originator
Daiichi Seiyaku; Seishin Seiyaku (Japan)
Uses
Bucladesine sodium is an analog of cyclic AMP that stimulates cAMP-dependent protein kinase. It has vasodilator properties and is used as a cardiac stimulant.
Definition
ChEBI: Bucladesine sodium is a 3',5'-cyclic purine nucleotide.
Application
N6,2′-O-Dibutyryladenosine 3′,5′-cyclic monophosphate sodium salt has been used:
as a medium supplement for neural crest stem cells (NCSCs) differentiation
as a component of thawing medium for cryopreserved human iPSC (induced pluripotent stem cell)-derived neurons
in serum-free Dulbecco′s modified eagle′s medium (DMEM) to induce astrocyte differentiation
brand name
ACTOCIN
General Description
A cell-permeable cAMP analog that preferentially activates cAMP-dependent protein kinase (PKA). Causes an increase in the steady state level of parathyroid hormone-related peptide mRNA. Also acts as a Hh pathway antagonist. Shown to induce apoptosis in vascular smooth muscle cells.
Biochem/physiol Actions
Cell-permeable cAMP analog that activates cAMP dependent protein kinase (PKA).
storage
Store at -20°C
References
1) Bartsch?et al.?(2003),?Bioactivatable, membrane-permeant analogs of cyclic nucleotides as biological tools for growth control of C6 glioma cells; Biol. Chem.,?384?1321
2) Carranza?et al.?(1998),?Protein kinase A induces recruitment of active Na+,K+-ATPase units to the plasma membrane of rat proximal convoluted tubule cells; J. Physiol.,?15?511
3) Hei?et al.?(1991),?Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs; Mol. Pharmacol.,?39?233
4) Imamura?et al.?(1998),?Differential expression of dystrophin isoforms and utrophin during dibutyryl-cAMP-induced morphological differentiation of rat brain astrocytes; Proc. Natl. Acad. Sci. USA,?95?6139
5) Xia?et al.?(2016),?Transcriptional comparison of human induced and primary midbrain dopaminergic neurons; Sci. Rep.,?6?20270
Bucladesine sodium Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
HangZhou RunYan Pharma Technology Co.,LTD. | +86-88660901 +86-18112526015 | sales@runyanpharma.com | China | 326 | 58 |
Hangzhou Meiya Pharmaceutical Co Ltd | +86-021-33686691 +8618001850931 | sales@meiyapharm.com | China | 57 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 | peter@yan-xi.com | China | 6011 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21687 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32715 | 60 |
Shanxi Naipu Import and Export Co.,Ltd | +86-13734021967 +8613734021967 | kaia@neputrading.com | China | 1011 | 58 |
Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 967 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
Shanghai Longyu Biotechnology Co., Ltd. | +8615821988213 | info@longyupharma.com | China | 2531 | 58 |
View Lastest Price from Bucladesine sodium manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-03-11 | Bucladesine sodium salt (DB-cAMP.Na)
16980-89-5
|
US $0.00-0.00 / kg | 1kg | ≥95% | 5000kg | Hangzhou Meiya Pharmaceutical Co Ltd | ||
2023-11-14 | Bucladesine
16980-89-5
|
US $0.00 / kg | 1kg | 0.99 | 20 tons | Hebei Yanxi Chemical Co., Ltd. | ||
2023-09-06 | Bucladesine
16980-89-5
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. |
- Bucladesine sodium salt (DB-cAMP.Na)
16980-89-5
- US $0.00-0.00 / kg
- ≥95%
- Hangzhou Meiya Pharmaceutical Co Ltd
- Bucladesine
16980-89-5
- US $0.00 / kg
- 0.99
- Hebei Yanxi Chemical Co., Ltd.
- Bucladesine
16980-89-5
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
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