CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)
![CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Structure](CAS/20200611/GIF/162760-96-5.gif)
- CAS No.
- 162760-96-5
- Chemical Name:
- CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3)
- Synonyms
- N-ethyl]piperazinyl]methoxyphenyl)WAY 100635;WAY100635;cyclohexanecarboxamiWAY100635 TRIHYDROCHLORIDE;WAY-100635;WAY 100635; WAY100635;Cyclohexanecarboxamide,N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinyl-;N-{2-[4-(2-Methoxyphenyl)piperazin-1-yl]ethyl}-N-(pyridin-2-yl)cyclohexanecarboxaMide
- CBNumber:
- CB82448237
- Molecular Formula:
- C25H34N4O2
- Molecular Weight:
- 422.56
- MDL Number:
- MFCD00916243
- MOL File:
- 162760-96-5.mol
- MSDS File:
- SDS
CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Properties
| Melting point | >145oC (dec.) |
|---|---|
| Boiling point | 594.8±50.0 °C(Predicted) |
| Density | 1.154±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| pka | 6.84±0.10(Predicted) |
| color | Off-White to Pale Yellow |
| Stability | Hygroscopic |
| FDA UNII | 71IH826FEG |
CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | W498665 | WAY100635 | 162760-96-5 | 250mg | $215 | 2021-12-16 | Buy |
| ApexBio Technology | A3933 | WAY-100635 | 162760-96-5 | 10mg | $102 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | BRS0000230 | WAY-100635 TRIHYDROCHLORIDE 95.00% | 162760-96-5 | 10MG | $792 | 2021-12-16 | Buy |
| DC Chemicals | DC22622 | WAY-100635 >98% | 162760-96-5 | 1g | $800 | 2021-12-16 | Buy |
| Crysdot | CD31003127 | WAY-100635 98+% | 162760-96-5 | 10mg | $64 | 2021-12-16 | Buy |
CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Chemical Properties,Uses,Production
Uses
WAY 100635 exhibits high affinity and efficacy at the dopamine D4 receptor (1,2,3). WAY 100635 is a potent 5-HT1A antagonist.
Definition
ChEBI: N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide is a member of piperazines.
Biological Activity
5-ht1a receptors mediate various serotonergic functions and may be implicated in various pathologies including depressive and anxiety disorders, alzheimer’s disease, and schizophrenia. way-100635 is a potential spect ligands for the 5-ht1a receptor.
in vitro
way-100635 displaced specific binding of the 5-ht1a radioligand, [3h]8-oh-dpat, to rat hippocampal membranes with a plc50 of 8.87. in functional assays, way-100635 was a potent 5-ht1a receptor antagonist, with no evidence of any 5-htia receptor agonist or partial agonist activity. in the isolated guinea-pig ileum way-100635 was a potent and, at high concentrations, an insurmountable antagonist of the 5-ht1a receptor agonist action of 5-carboxamidotryptamine, with an apparent pa 2 value (at 0.3 nm) of 9.71 [2].
in vivo
way-100635 blocked the inhibitory action of 8-oh-dpat on dorsal raphe neuronal firing in the anaesthetised rat at doses which had no inhibitory action per se. in behavioural models, way-100635 itself induced no overt behavioural changes but potently antagonised the behavioural syndrome induced by 8-oh-dpat in the rat and guinea-pig (minimum effective dose = 0.003 mg/kg s.c. and id50 = 0.01 mg/kg s.c., respectively). way-100635 also blocked the hypothermia induced by 8-oh-dpat in the mouse and rat with id50 values of 0.01 mg/kg s.c. [2].
target
5-HT1A receptor
References
[1] al hussainy r, verbeek j, van der born d, braker ah, leysen je, knol rj, booij j, herscheid jk. design, synthesis, radiolabeling, and in vitro and in vivo evaluation of bridgehead iodinated analogues of n-{2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl}-n-(pyridin-2-yl)cyclohexanecarboxamide (way-100635) as potential spect ligands for the 5-ht1a receptor. j med chem. 2011;54(10):3480-91.
[2] forster ea, cliffe ia, bill dj, dover gm, jones d, reilly y, fletcher a. a pharmacological profile of the selective silent 5-ht1a receptor antagonist, way-100635. eur j pharmacol. 1995;281(1):81-8.
CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38632 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| NCE Biomedical Co.,Ltd. | 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 | China | 1493 | 55 | |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-400-6206333 18521732826 | market@aladdin-e.com | China | 25003 | 65 |
| AdooQ BioScience, LLC | +1 (866) 930-6790 | info@adooq.com | United States | 2782 | 58 |
| ShangHai KenEn Chemical Technology Co., Ltd. | 13120367189 | mychess007@163.com | China | 1994 | 55 |
View Lastest Price from CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2024-10-28 | WAY-100635
162760-96-5
|
US $73.00 / mg | 10g | TargetMol Chemicals Inc. |
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- WAY-100635
162760-96-5
- US $73.00 / mg
- TargetMol Chemicals Inc.
CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3) Spectrum
162760-96-5(CYCLOHEXANECARBOXAMIDE, N-[2-[4-(2-METHOXYPHENYL)-1-PIPERAZINYL]ETHYL]-N-2-PYRIDINYL-, HYDROCHLORIDE (1:3))Related Search:
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