3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
- CAS No.
- 677297-51-7
- Chemical Name:
- 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
- Synonyms
- CS-427;100-115;T 100-115;TG100-115, >=98%;TG100115; TG100 115;TG100-115, 10 mM in DMSO;TG100-115;TG100115;TG100 115;3,3'-(2,4-Diamino-6,7-pteridinediyl)bispheno;3,3,-(2,4-diaminopteridine-6,7-diyl)diphenol;3,3'-(2,4-Diaminopteridine-6,7-diyl)diphenol
- CBNumber:
- CB82484695
- Molecular Formula:
- C18H14N6O2
- Molecular Weight:
- 346.34
- MDL Number:
- MFCD16038873
- MOL File:
- 677297-51-7.mol
- MSDS File:
- SDS
| Boiling point | 699.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.516±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥3.46 mg/mL in DMSO |
| form | Yellow powder solid. |
| pka | 8.54±0.10(Predicted) |
| color | Light yellow to yellow |
| FDA UNII | 7ACH1U1E2M |
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TRC | T337795 | TG100-115 | 677297-51-7 | 10mg | $120 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0000880 | TG-100115 95.00% | 677297-51-7 | 1G | $9799.02 | 2021-12-16 | Buy |
| ChemScene | CS-0186 | TG100-115 99.31% | 677297-51-7 | 5mg | $96 | 2021-12-16 | Buy |
| ApexBio Technology | A2754 | TG100-115 | 677297-51-7 | 5mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FB43326 | 6,7-Bis(3-hydroxyphenyl)pteridine-2,4-diamine | 677297-51-7 | 25mg | $100 | 2021-12-16 | Buy |
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Chemical Properties,Uses,Production
Uses
TG100-115 is a potent and selective phosphoinositide 3-kinase gamma/delta (PI3Kγ/δ) inhibitor. It can provide potent cardioprotection, reduce infarct development, and preserve myocardial function.
Definition
ChEBI: 3-[2,4-diamino-7-(3-hydroxyphenyl)-6-pteridinyl]phenol is a member of pteridines.
Biological Activity
tg100-115 is an inhibitor of pi3kγ and pi3kδ with ic50 values of 83 nm and 235 nm, respectively. tg100-115 shows no obvious activity against pi3kα and pi3kβ [1].tg100-115 remarkably reduced eosinophil accumulation, balf levels of classic th2 cytokine il-13, perivascular and peribronchial leukocyte accumulations, and bronchiolar mucin accumulation in a murine model. besides, tg100-115 showed to reduce airway hyper-responsiveness (ahr) by approximately 50% in asthmatic mice. moreover, tg100-115 has been reported to reduce both smoke-and lps-induced neutrophil and lps-induced classic th1 cytokine tnfα accumulations in mice [2].
in vivo
To correlate these in vivo responses with the molecular target of interest, PI3K pathway signaling is monitored through western blot analyses of Akt phosphorylation (a PI3K-mediated event). VEGF injection i.v. in mice induces a rapid Akt phosphorylation readily detectable in lung lysates, pretreatment with TG100-115 blocks this response. Blockade is seen with TG100-115 doses as low as 0.5 mg/kg and persists over a period of several hours. In initial dose-ranging studies, generally equivalent responses are observed using TG100-115 doses of 0.5-10 mg/kg, and we therefore elected to conduct a statistically powered test at the lowest dose. Animals dosed with TG100-115 as a single 0.5 mg/kg i.v. bolus 30 min after reperfusion developed smaller infarcts vs. vehicle-treated controls. Measuring infarct area as percent of total LV ischemic area, infarct size is reduced by 35% (P=0.04). Viable tissue within the ischemic zone is increased by 37% (P=0.04), directly demonstrating the cardioprotective effect of PI3Kγ/δ inhibition[1].
target
PI3K-γ
IC 50
PI3Kγ: 83 nM (IC50); PI3Kδ: 235 nM (IC50)
References
[1] doukas j1, wrasidlo w, noronha g, dneprovskaia e, fine r, weis s, hood j, demaria a, soll r, cheresh d. hosphoinositide 3-kinase gamma/delta inhibition limits infarct size after myocardial ischemia/reperfusion injury. proc natl acad sci u s a. 2006 dec 26;103(52):19866-71.
[2] doukas j1, eide l, stebbins k, racanelli-layton a, dellamary l, martin m, dneprovskaia e, noronha g, soll r, wrasidlo w, acevedo lm, cheresh da. aerosolized phosphoinositide 3-kinase gamma/delta inhibitor tg100-115 [3-[2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl]phenol] as a therapeutic candidate for asthma and chronic obstructive pulmonary disease. j pharmacol exp ther. 2009 mar;328(3):758-65.
3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29858 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22963 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | eric@witopchemical.com | China | 23541 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | info@dycnchem.com | China | 52849 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
View Lastest Price from 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2022-02-19 | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bispheno
677297-51-7
|
US $0.00 / gram | 1gram | 99% | 10kg | Zhejiang J&C Biological Technology Co.,Limited | |
 |
2019-07-06 | 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
677297-51-7
|
US $2.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- 3,3'-(2,4-Diamino-6,7-pteridinediyl)bispheno
677297-51-7
- US $0.00 / gram
- 99%
- Zhejiang J&C Biological Technology Co.,Limited
-
- 3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol
677297-51-7
- US $2.00 / kg
- 99%
- Career Henan Chemical Co
677297-51-7(3,3'-(2,4-Diamino-6,7-pteridinediyl)bisphenol)Related Search:
1of4