ChemicalBook >> CAS DataBase List >>[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid structure

CAS No.: 378247-75-7

Chemical Name:: [7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid

Synonyms: Fmoc-7-aminocoumarin-4-acetic acid;Pyridine,2,3,6-trichloro-8-nitro-;N-Fmoc-Aminocoumarin-4-acetic acid;7-N-Fmoc-aminocoumarin-4-acetic acid;7-(Fmoc-amino)-2-oxo-2H-1-benzopyran-4-acetic acid;7-(9-Fluorenylmethyloxycarbonylamino)-coumarin-4-acetic acid;[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid;7-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-oxo-2H-1-benzopyran-4-acetic acid;2-(7-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-oxo-2H-chromen-4-yl)aceticaci;2H-1-Benzopyran-4-acetic acid, 7-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-oxo-

CBNumber:: CB82489625

Molecular Formula:: C26H19NO6

Molecular Weight:: 441.43

MDL Number:: MFCD13195295

MOL File:: 378247-75-7.mol

Last updated:2023-07-14 17:43:39

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[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid Properties

Melting point	273-276 °C
Boiling point	660.5±55.0 °C(Predicted)
Density	1.418±0.06 g/cm3(Predicted)
storage temp.	Store at +2°C to +8°C.
pka	4.23±0.10(Predicted)

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AK Scientific	KMA0040	7-N-Fmoc-Aminocoumarin-4-aceticacid	378247-75-7	100mg	$264	2021-12-16	Buy
Iris Biotech GmbH	RL-1170	Fmoc-ACA-OH	378247-75-7	1g	$270	2021-12-16	Buy
AK Scientific	2787CS	2-(7-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-oxo-2H-chromen-4-yl)aceticacid	378247-75-7	100mg	$293	2021-12-16	Buy
Biosynth Carbosynth	FA36373	7-N-Fmoc-Aminocoumarin-4-acetic acid	378247-75-7	500mg	$300	2021-12-16	Buy
American Custom Chemicals Corporation	CHM0078619	7-N-FMOC-AMINOCOUMARIN-4-ACETIC ACID 95.00%	378247-75-7	5G	$909.56	2021-12-16	Buy

Product number	Packaging	Price	Buy
KMA0040	100mg	$264	Buy
RL-1170	1g	$270	Buy
2787CS	100mg	$293	Buy
FA36373	500mg	$300	Buy
CHM0078619	5G	$909.56	Buy

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid Chemical Properties,Uses,Production

General Description

Fmoc-ACA-OH is a useful tool for the SPPS of AMC fluorogenic protease substrates. Fmoc-ACA-OH [1] must be first loaded onto a Wang-type resin. Any unreacted linker hydroxyls must be capped using acetic anhydride. Following Fmoc removal, the first amino acid should be coupled withy HATU/collidine [2]. Insertion of ACA into the middle of a peptide provides fluorogenic substrates for endopeptidases [3]. Treatment of the ACC peptide obtained after TFA cleavage with aqueous base causes facile decarboxylation and formation of the AMC peptide.

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid synthesis

Synthesis of [7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid from 3-Aminophenol

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid Preparation Products And Raw materials

Raw materials

ETHYL (3-HYDROXYPHENYL)CARBAMATE 7-Amino-4-carboxymethylcoumarin 3-Aminophenol 9-Fluorenylmethyl chloroformate

Preparation Products

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid Suppliers

Global( 41)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30253	58
GL Biochem (Shanghai) Ltd.	+86-021-61263370 +86-18901917034		CHINA	3904	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33350	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
Shanghai Ennopharm Co., Ltd.	+86 (21) 6435-5022		China	4271	65
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	025-66113011 18112977050	cb6@aikonchem.com	China	16687	50
Hangzhou Milestone Pharmtech Co., Ltd.	0571-82896630 18969958410	sales_hz@milestonepharmtech.com	China	4849	55
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51471	80

Supplier	Advantage
Alchem Pharmtech,Inc.	58
Career Henan Chemica Co	58
GL Biochem (Shanghai) Ltd.	58
Nextpeptide Inc	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Amadis Chemical Company Limited	58
Shanghai Ennopharm Co., Ltd.	65
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.	50
Hangzhou Milestone Pharmtech Co., Ltd.	55
Sigma-Aldrich	80

[7-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-oxo-2H-chromen-4-yl]-aceticacid 2-(7-((((9H-Fluoren-9-yl)Methoxy)carbonyl)aMino)-2-oxo-2H-chroMen-4-yl)acetic acid 7-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-2-oxo-2H-1-benzopyran-4-acetic acid 7-N-Fmoc-aminocoumarin-4-acetic acid 2-[7-[[9H-fluoren-9-ylmethoxy(oxo)methyl]amino]-2-oxo-1-benzopyran-4-yl]acetic acid 2H-1-Benzopyran-4-acetic acid, 7-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-oxo- N-Fmoc-Aminocoumarin-4-acetic acid Fmoc-7-aminocoumarin-4-acetic acid 2-(7-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2-oxo-2H-chromen-4-yl)aceticaci Pyridine,2,3,6-trichloro-8-nitro- 7-(Fmoc-amino)-2-oxo-2H-1-benzopyran-4-acetic acid 7-(9-Fluorenylmethyloxycarbonylamino)-coumarin-4-acetic acid 378247-75-7