1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
- CAS No.
- 147591-46-6
- Chemical Name:
- 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol
- Synonyms
- ID 8;CS-989;ID 8; ID8;ID 8 free base;1-(4-methoxyphenyl)-2-methyl-3-nitroindol-6-ol;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol;1H-Indol-6-ol, 1-(4-methoxyphenyl)-2-methyl-3-nitro-;1-(4-methoxy-phenyl)-2-methyl-3-nitro-1H-indole-6-ol;1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol ID8;cell,embryonic,dual-specificity,DYRK,ESC,Inhibitor,inhibit,ID 8,Dual specificity tyrosine phosphorylation regulated kinase,stem,regulated,phosphorylation,kinase,tyrosine,ID-8,Dual specificity tyrosine regulated kinase
- CBNumber:
- CB82510019
- Molecular Formula:
- C16H14N2O4
- Molecular Weight:
- 298.29
- MDL Number:
- MFCD00593367
- MOL File:
- 147591-46-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| Hazard Codes | Xn,N | |||||||||
| Risk Statements | 22-50 | |||||||||
| Safety Statements | 61 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.99.8290 | |||||||||
| NFPA 704 |
|
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol price More Price(38)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | I1786 | ID 8 ≥98% (HPLC) | 147591-46-6 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | I1786 | ID 8 ≥98% (HPLC) | 147591-46-6 | 25mg | $379 | 2024-03-01 | Buy |
| TCI Chemical | I1108 | ID 8 | 147591-46-6 | 10MG | $123 | 2024-03-01 | Buy |
| TCI Chemical | I1108 | ID 8 | 147591-46-6 | 50MG | $425 | 2024-03-01 | Buy |
| Cayman Chemical | 15222 | ID 8 ≥98% | 147591-46-6 | 5mg | $56 | 2024-03-01 | Buy |
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Chemical Properties,Uses,Production
Description
ID-8 (147591-46-6) enhances stem cell proliferation and protects pluripotency in culture.1?Inhibits Dual-specificity tyrosine phosphorylation-regulated kinase (DYRK).2
Uses
ID 8 is an indole derivative that sustains embryonic stem cell self-renewal in long-term culture.
General Description
ID-8 is an inhibitor of dual-specificity tyrosine-phosphorylation-regulated kinase 1A (DYRK1A).
Biochem/physiol Actions
ID-8 sustains self-renewal and pluripotency of mouse embryonic stem cells (ESCs) in vitro. Stimulates proliferation at a steady rate (observed in serum-free media supplemented with 10 μM over a 30 day period).
storage
+4°C
References
1) Miyabayashi?et al. (2008),?Indole derivatives sustain embryonic stem cell self-renewal in long term culture; Biosci. Biotechnol. Biochem.,?72?1242 2) Hasegawa?et al. (2012),?Wnt signaling orchestration with a small molecule DYRK inhibitor provides long-term xeno-free human pluripotent cell expansion?; Stem Cells Translat. Med., 1?18
1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49392 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |