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Chk2 Inhibitor

Chk2 Inhibitor Structure
Chk2 Inhibitor structure
CAS No.
724708-21-8
Chemical Name:
Chk2 Inhibitor
Synonyms
SC203885;SC-203885;SC 203885;Chk2 Inhibitor;Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem;Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)-
CBNumber:
CB82514668
Molecular Formula:
C15H13N5O2
Molecular Weight:
295.3
MDL Number:
MFCD22380609
MOL File:
724708-21-8.mol
Last updated:2024-10-23 13:36:13
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Chk2 Inhibitor Properties

storage temp. -20C
solubility DMSO: Soluble
form Pale yellow solid

Chk2 Inhibitor price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21184 Chk2 Inhibitor 724708-21-8 500μg $242 2024-03-01 Buy
Cayman Chemical 21184 Chk2 Inhibitor 724708-21-8 1mg $387 2024-03-01 Buy
TRC C263468 Chk2Inhibitor 724708-21-8 1000μg $645 2021-12-16 Buy
Product number Packaging Price Buy
21184 500μg $242 Buy
21184 1mg $387 Buy
C263468 1000μg $645 Buy

Chk2 Inhibitor Chemical Properties,Uses,Production

Uses

Chk2 Inhibitor is a checkpoint kinase inhibitor that mediates apoptosis and cell cycle arrest.

General Description

A cell-permeable, ATP competitive, and reversible indoloazepine compound that displays anti-proliferative and anti-inflammatory properties. Acts as a potent inhibitor of Chk2 (IC50 = 8 nM) that targets the ATP binding pocket. Exhibits selectivity for Chk2 over MEK1, Chk1, CK1δ, PKCα, PKCβII and CK2 (IC50 = 89 nM, 237 nM, 1.352 μM, 2.539 μM, 3.381 μM, and >10.0 μM, respectively). Blocks the production of IL-2 and TNF-α by preventing the transcriptional activation of NF-κB (IC50 = 3.55 μM for IL-2 production in PMA-stimulated Jurkat T cells; 8.16 μM for TNF-α production in LPS-stimulated THP-1 cells). Also reported to suppress the growth of leukemic T cells (GI50 = 1.73 μM).

Biochem/physiol Actions

Primary TargetChk2

Chk2 Inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

Chk2 Inhibitor Suppliers

Global( 16)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32165 58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		027-88013699 17354350817 Ryan@jiutian-bio.com China 6001 58
Aladdin Scientific 		+1-+1(833)-552-7181 sales@aladdinsci.com United States 52924 58
VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14055 65
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 info@efebio.com China 9806 58
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6777 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11217 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24647 58
Shanghai Yiyan Biotechnology Co. , Ltd. 021-69985186 13611928337 3427709316@qq.com China 7979 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd 		58
Aladdin Scientific 		58
VDM Biochemicals 64
BOC Sciences 65
Shanghai EFE Biological Technology Co., Ltd. 58
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yiyan Biotechnology Co. , Ltd. 58

View Lastest Price from Chk2 Inhibitor manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
SC-203885 pictures 2024-10-24 SC-203885
724708-21-8
 US $968.00 / mg 10g TargetMol Chemicals Inc.
  • SC-203885 pictures
  • SC-203885
    724708-21-8
  • US $968.00 / mg
  • TargetMol Chemicals Inc.

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Chk2 Inhibitor Chk2 Inhibitor - CAS 724708-21-8 - Calbiochem Azepino[3,4-b]indol-1(2H)-one, 5-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-3,4,5,10-tetrahydro-, (5Z)- SC 203885 SC203885 SC-203885 724708-21-8 Cholinergics