GSK1292263
- CAS No.
- 1032823-75-8
- Chemical Name:
- GSK1292263
- Synonyms
- CS-417;GSK1292263;GSK1292263 USP/EP/BP;GSK-1292263;GSK 1292263;GPR119 receptor agonist GS1292263;GPR119 Agonist II GSK1292263 GSK-1292263;3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-;3-Isopropyl-5-(4-(((6-(4-(methylsulfonyl)phenyl)pyridin-3-yl)oxy)methyl)piperidin-1-yl)-1,2,4-oxa;5-((1-(3-isopropyl-1,2,4-oxadiazol-5-yl)piperidin-4-yl)methoxy)-2-(4-(methylsulfonyl)phenyl)pyridine;3-isopropyl-5-(4-(((6-(4-(Methylsulfonyl)phenyl)pyridin-3-yl)oxy)Methyl)piperidin-1-yl)-1,2,4-oxadiazole
- CBNumber:
- CB82522975
- Molecular Formula:
- C23H28N4O4S
- Molecular Weight:
- 456.56
- MDL Number:
- MFCD18385004
- MOL File:
- 1032823-75-8.mol
- MSDS File:
- SDS
| Boiling point | 655.1±65.0 °C(Predicted) |
|---|---|
| Density | 1.23 |
| storage temp. | Store at -20°C |
| solubility | ≥21.1 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| form | solid |
| pka | 4.75±0.32(Predicted) |
| color | White to off-white |
| FDA UNII | R1J57STA6O |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H320-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
GSK1292263 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 26181 | GSK1292263 | 1032823-75-8 | 5mg | $119 | 2024-03-01 | Buy |
| Cayman Chemical | 26181 | GSK1292263 | 1032823-75-8 | 50mg | $813 | 2024-03-01 | Buy |
| Cayman Chemical | 26181 | GSK1292263 | 1032823-75-8 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 26181 | GSK1292263 | 1032823-75-8 | 25mg | $501 | 2024-03-01 | Buy |
| ChemScene | CS-0228 | GSK1292263 99.71% | 1032823-75-8 | 10mg | $150 | 2021-12-16 | Buy |
GSK1292263 Chemical Properties,Uses,Production
Biological Activity
gsk1292263 is a novel agonist of gpr119 receptor agonist and is used for the treatment of type 2 diabetes.gpr119 is described as a class a (rhodopsin-type) orphan gpcr with no close primary sequence relative in the human genome. the activation of gpr119 increases the intracellular accumulation of camp, resulting in enhanced insulin secretion from pancreatic β-cells and increased release of the gut peptides glp-1 (glucagon-like peptide 1), gip (glucose-dependent insulinotropic peptide) and pyy (polypeptide yy).in vitro, gsk1292263 treatment displayed little inhibition towards cyps (cyp1a2, 2c9, 2c19, 2d6, 3a4), p-gp, oatp1b3, or oct2. however, gsk1292263 inhibited bcrp and oatp1b1, which are transporters involved in statin disposition 1.in the glucose tolerance test in rats, administration of gsk-1292263 significantly increases the peak insulin response and insulin auc (0-15 min) as compared with the values in the vehicle control. the upregulation of insulin was found to correlate with an increase in the glucose disposal rate. in hyperinsulinemic-euglycemic clamps, gsk-1292263 administration on sprague-dawley rats at dose of 10 or 30 mg/kg 2 hours prior to insulin infusion can promote glucagon secretion with no increase of blood glucose levels 2.
target
GPR119
References
1. polli jw, hussey e, bush m, et al. evaluation of drug interactions of gsk1292263 (a gpr119 agonist) with statins: from in vitro data to clinical study design. xenobiotica; the fate of foreign compounds in biological systems. 2013;43(6):498-508.2. zhu x, huang d, lan x, et al. the first pharmacophore model for potent g protein-coupled receptor 119 agonist. european journal of medicinal chemistry. 2011;46(7):2901-2907.
GSK1292263 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29791 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32957 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29881 | 58 |
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22783 | 58 |
View Lastest Price from GSK1292263 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-19 | GSK1292263
1032823-75-8
|
US $29.00-76.00 / mg | 99.46% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | GSK1292263
1032823-75-8
|
US $7.00 / kg | 1kg | 99% | 100kg | Career Henan Chemical Co |
-
- GSK1292263
1032823-75-8
- US $29.00-76.00 / mg
- 99.46%
- TargetMol Chemicals Inc.
-
- GSK1292263
1032823-75-8
- US $7.00 / kg
- 99%
- Career Henan Chemical Co