AS 1269574
- CAS No.
- 330981-72-1
- Chemical Name:
- AS 1269574
- Synonyms
- AS126957;AS 1269574;AS-1269574 (AS1269574);AS1269574, 10 mM in DMSO;2-(2-(4-Bromophenyl)-6-methylpyrimidin-4-ylamino)ethanol;2-[[2-(4-BroMophenyl)-6-Methyl-4-pyrinidinyl]aMino]ethanol;2-[[2-(4-Bromophenyl)-6-methyl-4-pyrimidinyl]amino]ethanol;Ethanol, 2-[[2-(4-bromophenyl)-6-methyl-4-pyrimidinyl]amino]-;TRP Channel,G Protein-Coupled Receptor 119,secretion,Inhibitor,type,AS1269574,cation,diabetes,insulin,inhibit,Transient receptor potential channels,glucose,GPR119,channels,AS-1269574
- CBNumber:
- CB82535661
- Molecular Formula:
- C13H14BrN3O
- Molecular Weight:
- 308.17
- MDL Number:
- MFCD00298280
- MOL File:
- 330981-72-1.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| NFPA 704 |
|
AS 1269574 price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 371724 | GPR119 Agonist, AS1269574 The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications. | 330981-72-1 | 10MG | $166 | 2024-03-01 | Buy |
| Cayman Chemical | 10626 | AS-1269574 ≥98% | 330981-72-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 10626 | AS-1269574 ≥98% | 330981-72-1 | 5mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 10626 | AS-1269574 ≥98% | 330981-72-1 | 10mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 10626 | AS-1269574 ≥98% | 330981-72-1 | 25mg | $257 | 2024-03-01 | Buy |
AS 1269574 Chemical Properties,Uses,Production
Uses
Acts as an orally available agonist of GPR119 (G-protein coupled receptor 119), a regulator of incretin and insulin hormone secretion.
Biological Activity
as 1269574,(2-[2-(4-bromophenyl)-6-methylpyrimidin-4-yl] amino ethanol), was capable of inducing glucose-stimulated insulin secretion (gsis) and improved glucose tolerance in normal mice. as 1269574 is an agonist of gpr119 with ec50 value of 2.5 μm [1] [2].gpr119 is highly expressed in pancreatic β-cells. this receptor enhances the effect of gsis via the elevation of intracellular camp concentrations [2].treated with either 1 or 10 μm as 1269574 for 20 min, the insulin secretion of mouse pancreatic min-6 β-cells pre-exposed to 16.8 mm glucose was significantly increased compared with the dmso vehicle control. in contrast, as 1269574 did not affect the insulin release of min-6 cells previously treated with low-glucose (2.8 mm) [2].in normal mice, a single treatment with 100 mg/kg of as 1269574 significantly reduced the area under the curve (auc) after 2 h (auc0-2h) of blood glucose. as 1269574 significantly increase the plasma insulin auc0-2h in mice compared with the vehicle control. a single oral administration of 100 mg/kg as 1269574 did not significantly lower the blood glucose auc in either fasted or fed mice, indicating as 1269574 did not have a hypoglycemic effect [2].
References
[1]. shigeru yoshida, hirotsugu tanaka, hiroyuki oshima, et al. as1907417, a novel gpr119 agonist, as an insulinotropic and β-cell preservative agent for the treatment of type 2 diabetes. biochemical and biophysical research communications, 2010, 400: 745-751.
[2]. shigeru yoshida, takahide ohishi, tetsuo matsui, et al. identification of a novel gpr119 agonist, as1269574, with in vitro and in vivo glucose-stimulated insulin secretion. biochemical and biophysical research communications, 2010, 400: 437-441.
AS 1269574 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14055 | 65 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4727 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| TargetMol Chemicals Inc. | 58 |
| InvivoChem | 58 |
| Aladdin Scientific | 58 |
| J & K SCIENTIFIC LTD. | 76 |
| BOC Sciences | 65 |
| Dalian Meilun Biotech Co., Ltd. | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 58 |
| LETOPHARM LIMITED | 58 |
| EMMX Biotechnology LLC | 60 |
