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Triethyl 1,1,2-ethanetricarboxylate

Triethyl 1,1,2-ethanetricarboxylate structure

CAS No.: 7459-46-3

Chemical Name:: Triethyl 1,1,2-ethanetricarboxylate

Synonyms: triethyl ethane-1,1,2-tricarboxylate;TETC;LABOTEST-BB LT00452668;1,1,2-Tricarbethoxyethane;Triethyl 1,1,2-ethanetricarb;Triethyl ethane tricarboxylate;TRIETHYL 1,1,2-ETHANETRICARBOXYLATE;Triethyl ethane-1,2,2-tricarboxylate;Triethyle1, 1, 2-ethanetricarboxylate;Diethyl 2-(Ethoxycarbonyl)butanedioate

CBNumber:: CB8254360

Molecular Formula:: C11H18O6

Molecular Weight:: 246.26

MDL Number:: MFCD00009154

MOL File:: 7459-46-3.mol

MSDS File:: SDS

Last updated:2026-01-13 11:25:47

Product description	Number	Pack Size	Price
Triethyl 1,1,2-ethanetricarboxylate 99%	T59854	25g	$81.5
Triethyl 1,1,2-ethanetricarboxylate 99%	T59854	100g	$144.9
Triethyl 1,1,2-Ethanetricarboxylate >96.0%(GC)	T2431	5g	$21
Triethyl 1,1,2-Ethanetricarboxylate >96.0%(GC)	T2431	25g	$61
1,1,2-EthanetricarboxylicAcid1,1,2-TriethylEster	E676480	10g	$130
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Triethyl 1,1,2-ethanetricarboxylate Properties

Boiling point	99 °C/0.5 mmHg (lit.)
Density	1.074 g/mL at 25 °C (lit.)
refractive index	n20/D 1.429(lit.)
Flash point	>230 °F
storage temp.	Sealed in dry,Room Temperature
solubility	Chloroform, Ethyl Acetate
pka	11.78±0.59(Predicted)
form	Liquid
Specific Gravity	1.074
color	Clear colorless
BRN	1796294
Dielectric constant	6.5（19.0℃）
InChI	InChI=1S/C11H18O6/c1-4-15-9(12)7-8(10(13)16-5-2)11(14)17-6-3/h8H,4-7H2,1-3H3
InChIKey	TVWZLLYAJDSSCJ-UHFFFAOYSA-N
SMILES	C(C(=O)OCC)(C(=O)OCC)CC(=O)OCC
CAS DataBase Reference	7459-46-3(CAS DataBase Reference)
NIST Chemistry Reference	1,1,2-Ethanetricarboxylic acid, triethyl ester(7459-46-3)
UNSPSC Code	12352100
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06,GHS02

Signal word

Danger

Hazard statements

H301-H226

Precautionary statements

P501-P270-P240-P210-P233-P243-P241-P242-P264-P280-P370+P378-P303+P361+P353-P301+P310+P330-P403+P235-P405

PPE

Eyeshields, Gloves

Safety Statements

23-24/25

WGK Germany

HS Code

29420000

Storage Class

10 - Combustible liquids

NFPA 704

	0
0		0

Triethyl 1,1,2-ethanetricarboxylate price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	T59854	Triethyl 1,1,2-ethanetricarboxylate 99%	7459-46-3	25g	$81.5	2025-07-31	Buy
Sigma-Aldrich	T59854	Triethyl 1,1,2-ethanetricarboxylate 99%	7459-46-3	100g	$144.9	2025-07-31	Buy
TCI Chemical	T2431	Triethyl 1,1,2-Ethanetricarboxylate >96.0%(GC)	7459-46-3	5g	$21	2025-07-31	Buy
TCI Chemical	T2431	Triethyl 1,1,2-Ethanetricarboxylate >96.0%(GC)	7459-46-3	25g	$61	2025-07-31	Buy
TRC	E676480	1,1,2-EthanetricarboxylicAcid1,1,2-TriethylEster	7459-46-3	10g	$130	2021-12-16	Buy

Product number	Packaging	Price	Buy
T59854	25g	$81.5	Buy
T59854	100g	$144.9	Buy
T2431	5g	$21	Buy
T2431	25g	$61	Buy
E676480	10g	$130	Buy

Triethyl 1,1,2-ethanetricarboxylate Chemical Properties,Uses,Production

Description

Triethyl 1,1,2-ethanetricarboxylate is a carboxylic acid ester compound that can be used in nanomaterials, pharmaceutical intermediates, organic synthesis and other fields.

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

1,1,2-Ethanetricarboxylic Acid 1,1,2-Triethyl Ester is a useful synthetic intermediate. It can be used to prepare Isobutylsuccinic Acid (I780660) which was used to synthesize succinimide derivatives as inhibitors of human leukocyte elastase, cathepsin G and proteinase 3.

Synthesis

105-39-5

105-53-3

7459-46-3

Step a): Sodium metal (23 g, 1 mole) was slowly added to anhydrous ethanol (500 mL) under stirring conditions until completely dissolved. Subsequently, diethyl malonate (160 g, 1 mole) was added dropwise over 30 min. After cooling the reaction mixture to 15°C, ethyl chloroacetate (117 g, 0.095 mol) was added dropwise over the same time. After the dropwise addition, the reaction mixture was refluxed for 6 hours. After completion of the reaction, the mixture was poured into 2 liters of water and the organic phase was extracted with dichloromethane (500 mL each time, three times). The organic extracts were combined, dried with anhydrous sodium sulfate, filtered and the solvent was evaporated to give an oily crude product. Finally, purification by vacuum distillation afforded triethyl ethyl-1,1,2-tricarboxylate (220 g, 89% yield).

References

[1] Patent: WO2013/29767, 2013, A1. Location in patent: Page/Page column 16; 17
[2] Patent: CN105566111, 2016, A. Location in patent: Paragraph 0029-30
[3] Liebigs Annalen der Chemie, 1983, # 1, p. 112 - 136
[4] Patent: WO2012/92880, 2012, A1. Location in patent: Page/Page column 45-46
[5] Justus Liebigs Annalen der Chemie, 1882, vol. 214, p. 38

Triethyl 1,1,2-ethanetricarboxylate synthesis

Synthesis of Triethyl 1,1,2-ethanetricarboxylate from Ethyl bromoacetate and Diethyl malonate

Triethyl 1,1,2-ethanetricarboxylate Preparation Products And Raw materials

Raw materials

Ethanol Sodium Sodium ethoxide Diethyl malonate Ethyl chloroacetate

Ethyl bromoacetate

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Preparation Products

Triethyl 1,1,2-ethanetricarboxylate Suppliers

Global( 199)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Finetech Industry Limited	+86-27-8746-5837 +8619945049750	info@finetechnology-ind.com	China	9629	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-81148696 +86-17392712697	1022@dideu.com	China	3995	58
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29831	58
Changzhou Ansciep Chemical Co., Ltd.	+86 519 86305871	sales@ansciepchem.com	CHINA	4241	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Wuhan Chemwish Technology Co., Ltd	027-67849912	sales@chemwish.com	CHINA	10821	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	+8613580539051	joe@yuhengpharm.com	CHINA	21142	58
SIMAGCHEM CORP	+86-5922680277 +86-13806087780	sale@simagchem.com	China	17346	58

Supplier	Advantage
Finetech Industry Limited	58
Shaanxi Dideu Medichem Co. Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Changzhou Ansciep Chemical Co., Ltd.	58
Alchem Pharmtech,Inc.	58
Wuhan Chemwish Technology Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
Guangzhou Yuheng Pharmaceutical Technology Co., Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from Triethyl 1,1,2-ethanetricarboxylate manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2025-12-24	TRIETHYL 1,1,2-ETHANETRICARBOXYLATE 7459-46-3	US $0.10 / KG	1KG	99.0%	1000 tons	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	TRIETHYL 1,1,2-ETHANETRICARBOXYLATE 7459-46-3	US $1.00 / kg	1kg	98%	100KG	Career Henan Chemical Co

TRIETHYL 1,1,2-ETHANETRICARBOXYLATE
7459-46-3
US $0.10 / KG
99.0%
Shaanxi Dideu Medichem Co. Ltd

TRIETHYL 1,1,2-ETHANETRICARBOXYLATE
7459-46-3
US $1.00 / kg
98%
Career Henan Chemical Co

Triethyl 1,1,2-ethanetricarboxylate Spectrum

TRIETHYL 1,1,2-ETHANETRICARBOXYLATE(7459-46-3)MS TRIETHYL 1,1,2-ETHANETRICARBOXYLATE(7459-46-3)¹HNMR TRIETHYL 1,1,2-ETHANETRICARBOXYLATE(7459-46-3)¹³CNMR TRIETHYL 1,1,2-ETHANETRICARBOXYLATE(7459-46-3)IR1 TRIETHYL 1,1,2-ETHANETRICARBOXYLATE(7459-46-3)Raman

7459-46-3(Triethyl 1,1,2-ethanetricarboxylate)Related Search:

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1,1,2-Tricarbethoxyethane Ethane-1,1,2-tricarboxylic acid, triethyl ester Triethyl ethane tricarboxylate Triethyl 1,1,2-ethanetricarboxylate 99% Triethyl1,1,2-ethanetricarboxylate/triethylethane-1,1,2-tricarboxylate Triethyle1, 1, 2-ethanetricarboxylate Triethyl ethane-1,2,2-tricarboxylate LABOTEST-BB LT00452668 2-(Ethoxycarbonyl)butanedioic Acid Diethyl Ester Diethyl 2-(Ethoxycarbonyl)butanedioate TRIETHYL 1,1,2-ETHANETRICARBOXYLATE TETC Triethyl 1,1,2-ethanetricarboxylate/1,1,2-Ethanetricarboxylic acid triethyl ester Triethyl 1,1,2-ethanetricarboxylate ,99% 1,1,2-Ethanetricarboxylic acid, 1,1,2-triethyl ester 1,1,2-Ethanetricarboxylic Acid Triethyl Ester Diethyl 2-(Ethoxycarbonyl)butanedioate 2-(Ethoxycarbonyl)butanedioic Acid Diethyl Ester Triethyl 1,1,2-ethanetricarb 1,1,2-triethyl ethane-1,1,2-tricarboxylate triethyl ethane-1,1,2-tricarboxylate 7459-46-3 C2H5O2CCH2CHCO2C2H52 C11H18O6 Esters Organic Building Blocks C10 to C11 Carbonyl Compounds Building Blocks Building Blocks C10 to C11 Carbonyl Compounds Chemical Synthesis Organic Building Blocks C10 to C11 Carbonyl Compounds Esters