Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>CAY10608

CAY10608

CAY10608 Structure
CAY10608 structure
CAS No.
457897-92-6
Chemical Name:
CAY10608
Synonyms
CAY10608;CAY10608 Exclusive;N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide;Methanesulfonamide, N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-
CBNumber:
CB82590442
Molecular Formula:
C18H22Cl2N2O4S
Molecular Weight:
433.35
MDL Number:
MFCD18382110
MOL File:
457897-92-6.mol
Last updated:2023-05-21 10:59:17
Request For Quotation

CAY10608 Properties

Boiling point 611.8±65.0 °C(Predicted)
Density 1.392±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 12.5 mg/ml; DMSO: 14 mg/ml; DMSO:PBS (pH 7.2) (1:10): 0.1 mg/ml
form A crystalline solid
pka 8.81±0.10(Predicted)

CAY10608 price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 13358 CAY10608 ≥98% 457897-92-6 1mg $38 2024-03-01 Buy
Cayman Chemical 13358 CAY10608 ≥98% 457897-92-6 5mg $166 2024-03-01 Buy
Cayman Chemical 13358 CAY10608 ≥98% 457897-92-6 10mg $292 2024-03-01 Buy
Cayman Chemical 13358 CAY10608 ≥98% 457897-92-6 25mg $638 2024-03-01 Buy
AK Scientific 1898AH N-[4-[(2S)-3-[[2-(3,4-Dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide 457897-92-6 10mg $424 2021-12-16 Buy
Product number Packaging Price Buy
13358 1mg $38 Buy
13358 5mg $166 Buy
13358 10mg $292 Buy
13358 25mg $638 Buy
1898AH 10mg $424 Buy

CAY10608 Chemical Properties,Uses,Production

Description

N-Methyl-D-aspartate (NMDA) receptors are Ca2+ permeable ligand-gated channels of the central nervous system that are activated after binding of the co-agonists glutamate and glycine. CAY10608 is a propanolamine that potently, selectively, and non-competitively antagonizes the NR2B subunit of NMDA receptors (IC50 = 50 nM).1 It does not inhibit NR1, NR2A, NR2C, and NR2D subunits and has no significant effects on α-amino-3-hydroxy-5-methyl-4-isoxazolepropioinic acid (AMPA) or kainate receptors.1 CAY10608 is neuroprotective, since it prevents NMDA-triggered release of lactate dehydrogenase from cultured cortical neurons. Also, CAY10608, when administered intraperitoneally, reduces brain infarct volume resulting from transient ischemia via carotid artery occlusion.1

References

1. Tahirovic, Y.A., Geballe, M., Gruszecka-Kowalik, E., et al. Enantiomeric propanolamines as selective N-methyl-D-aspartate 2B receptor antagonists J. Med. Chem. 51,5506-5521(2008).

CAY10608 Preparation Products And Raw materials

Raw materials

Preparation Products

CAY10608 Suppliers

Global( 14)Suppliers
Supplier Tel Email Country ProdList Advantage
BOC Sciences 1-631-485-4226; 16314854226 info@bocsci.com United States 14059 65
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 23963 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8739 58
Supplier Advantage
BOC Sciences 65
Shanghai Hongye Biotechnology Co. Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
CAY10608 N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]-methanesulfonamide CAY10608 Exclusive Methanesulfonamide, N-[4-[(2S)-3-[[2-(3,4-dichlorophenyl)ethyl]amino]-2-hydroxypropoxy]phenyl]- 457897-92-6