PPARγ Ligand Pack

Description

The Cayman PPARγ Ligand Pack contains a combination of frequently used ligands for the nuclear PPARγ. Each kit contains Ciglitazone, the first characterized member of the thiazolidinedione (TZD) class that binds to the PPARγ ligand-binding domain with an EC₅₀ value of 3.0 μM. Rosiglitazone, a key reference TZD also called BRL 49653, its more potent structural homolog MCC-555, and PPARγ-1-selective pioglitazone are other PPARγ agonists provided. Also included is Troglitazone (Resulin™), another TZD; it was withdrawn from human therapeutic use due to hepatotoxicity. Also in this assortment is 15-deoxy-Δ^12,14-Prostaglandin J₂, a potent PPARγ ligand derived from PGD₂. The actions of all of these compounds can be antagonized by the selective PPARγ antagonist, GW 9662, which is also in the kit.