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ChemicalBook >> CAS DataBase List >>1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Structure
1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- structure
CAS No.
918504-27-5
Chemical Name:
1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-
Synonyms
B-Raf IN 11;ZINC72115182;ZINC-72115182,ZINC72115182;B-Raf IN 11, 10 mM in DMSO;N-[3-(5-Bromo-7-azaindole-3-carbonyl)-2,4-difluorophenyl]-1-propanesulfonamide;N-(3-(5-broMo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide;N-{3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide;N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide;1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-;Propane-1-sulfonic acid [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]amide,
CBNumber:
CB82595245
Molecular Formula:
C17H14BrF2N3O3S
Molecular Weight:
458.28
MDL Number:
MFCD18207768
MOL File:
918504-27-5.mol
MSDS File:
SDS
Last updated:2025-04-18 09:52:51
Request For Quotation

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Properties

Density 1.689±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka 6.19±0.10(Predicted)
form Solid
color Off-white to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- price More Price(14)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation HCH0369680 N-(3-(5-BROMO-1H-PYRROLO[2,3-B]PYRIDINE-3-CARBONYL)-2,4-DIFLUOROPHENYL)PROPANE-1-SULFONAMIDE 95.00% 918504-27-5 5MG $495.67 2021-12-16 Buy
Matrix Scientific 100551 N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 95+% 918504-27-5 250mg $742 2021-12-16 Buy
AK Scientific 5505AC N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 918504-27-5 250mg $1051 2021-12-16 Buy
Matrix Scientific 100551 N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 95+% 918504-27-5 1g $1647 2021-12-16 Buy
Chemenu CM149556 N-(3-(5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide 95%+ 918504-27-5 5g $1397 2021-12-16 Buy
Product number Packaging Price Buy
HCH0369680 5MG $495.67 Buy
100551 250mg $742 Buy
5505AC 250mg $1051 Buy
100551 1g $1647 Buy
CM149556 5g $1397 Buy

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Chemical Properties,Uses,Production

Uses

B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1]

IC 50

B-RafV600E: 76 nM (IC50); BRAFWT: 238 nM (IC50)

References

[1] Yao H, et al. Identification and Characterization of Small-Molecule Inhibitors to Selectively Target the DFG-in over the DFG-out Conformation of the B-Raf Kinase V600E Mutant in Colorectal Cancer. Arch Pharm (Weinheim). 2016 Oct;349(10):808-815. DOI:10.1002/ardp.201600184

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

1-PropanesulfonaMide, N-[3-[[5-broMo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-

1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- Suppliers

Global( 56)Suppliers
Supplier Tel Email Country ProdList Advantage
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
career henan chemical co 		+86-0371-86658258 +8613203830695 sales@coreychem.com China 29858 58
Jinan Finer Chemical Co., Ltd 		+86-531-88989536 +86-15508631887 sales@finerchem.com China 2957 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Aceschem Inc. 		+1-817863-6948 +1-（817）863-6948 sales@aceschem.com United States 19632 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. 		+8618950047208 ellena@amitychem.com China 43416 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873 sales@chemdad.com China 39927 58
Supplier Advantage
ATK CHEMICAL COMPANY LIMITED 		60
career henan chemical co 		58
Jinan Finer Chemical Co., Ltd 		58
TargetMol Chemicals Inc. 		58
Aceschem Inc. 		58
Shanghai Acmec Biochemical Technology Co., Ltd. 		58
Aladdin Scientific 		58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		58
XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. 		58
Chongqing Chemdad Co., Ltd 		58

View Lastest Price from 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
B-Raf IN 11 pictures 2024-11-19 B-Raf IN 11
918504-27-5
 US $30.00 / mg 99.46% 10g TargetMol Chemicals Inc.
1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- pictures 2019-07-06 1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-
918504-27-5
 US $1.00 / KG 1KG 99% 1000KG Career Henan Chemical Co
  • B-Raf IN 11 pictures
  • B-Raf IN 11
    918504-27-5
  • US $30.00 / mg
  • 99.46%
  • TargetMol Chemicals Inc.
1-PropanesulfonaMide, N-[3-[(5-broMo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- N-(3-(5-broMo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonaMide N-[3-[(5-Bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide Propane-1-sulfonic acid [3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl]amide, ZINC72115182 B-Raf IN 11 ZINC-72115182,ZINC72115182 N-[3-(5-Bromo-7-azaindole-3-carbonyl)-2,4-difluorophenyl]-1-propanesulfonamide N-{3-[(5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide B-Raf IN 11, 10 mM in DMSO 918504-27-5 C17H14BrF2N3O3S