5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
![5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Structure](CAS/GIF/209481-24-3.gif)
- CAS No.
- 209481-24-3
- Chemical Name:
- 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride
- Synonyms
- SB 271046A;SB 271046A; SB-271046A;SB-271046A >=98% (HPLC);SB 271046 HCl (SB-271046A);SB 271046 hydrochloride, 10 mM in DMSO;SB 271046 hydrochloride, 5-HT6 antagonist;4-[(3-chloro-1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide;5-Chloro-N-(4-methoxy-3-piperazin-1-yl-phenyl)-3-methyl-2-benzo-thiophenesulfonamide hydrochloride;5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride;Benzo[b]thiophene-2-sulfonaMide, 5-chloro-N-[4-Methoxy-3-(1-piperazinyl)phenyl]-3-Methyl-, Monohydrochloride
- CBNumber:
- CB82604235
- Molecular Formula:
- C20H23Cl2N3O3S2
- Molecular Weight:
- 488.44
- MDL Number:
- MFCD10565914
- MOL File:
- 209481-24-3.mol
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Properties
| storage temp. | 2-8°C |
|---|---|
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | White to light brown |
| FDA UNII | X289JNP23G |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | nwg |
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride price More Price(17)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S5326 | SB-271046A ≥98% (HPLC) | 209481-24-3 | 5mg | $127 | 2024-03-01 | Buy |
| Sigma-Aldrich | S5326 | SB-271046A ≥98% (HPLC) | 209481-24-3 | 25mg | $500 | 2024-03-01 | Buy |
| Cayman Chemical | 18513 | SB-271046 (hydrochloride) ≥95% | 209481-24-3 | 5mg | $81 | 2024-03-01 | Buy |
| Cayman Chemical | 18513 | SB-271046 (hydrochloride) ≥95% | 209481-24-3 | 10mg | $152 | 2024-03-01 | Buy |
| Cayman Chemical | 18513 | SB-271046 (hydrochloride) ≥95% | 209481-24-3 | 25mg | $356 | 2024-03-01 | Buy |
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Chemical Properties,Uses,Production
Uses
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methyl-benzo[b]thiophene-2-sulfonamide Hydrochloride is a 5-Hydroxytryptamine6 receptor antagonist.
Biological Activity
The first potent and selective 5-HT6 antagonist. Training in cognitive tasks, as well as administration SB-271046, induces an increase in pERK1/2 and pCREB1 levels, while CREB2 levels are significantly reduced; cognition-enhancing properties of SB-271046 are attributed to the effect on pERK1/2, not pCREB1/2. SB-271046 reverses MK-801-induced, but not scopolamine-induced, learning impairments. However, with coadministration of galanthamine, both types of learning impairments were ameliorated.
in vivo
SB 271046 Hydrochloride (10?mg/kg; p.o.) produces an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ?0.1?mg/kg p.o. and maximum effect at 4?h post-dose[1].
| Animal Model: | Male Sprague Dawley rats[1] |
| Dosage: | 10?mg/kg |
| Administration: | P.o. |
| Result: | Produced an increase in seizure threshold over a wide-dose range in the rat maximal electroshock seizure threshold (MEST) test, with a minimum effective dose of ?0.1?mg?kg?1 p.o. and maximum effect at 4?h post-dose. The level of anticonvulsant activity achieved correlated well with the blood concentrations of SB-271046 (EC50 of 0.16?μM) and brain concentrations of 0.01-0.04?μM at Cmax. |
IC 50
5-HT6 Receptor: 8.92-9.02 (pKi); 5-HT1D Receptor: 6.55 (pKi); 5-HT1A Receptor: 6.35 (pKi); 5-HT1B Receptor: 6.05 (pKi); 5-HT1F Receptor: 5.95 (pKi); 5-HT2A Receptor: 5.62 (pKi); 5-HT2B Receptor: 5.41 (pKi); 5-HT7 Receptor: 5.39 (pKi); 5-HT4 Receptor: 5.27 (pKi); 5-HT1E Receptor: <4.99 (pKi); Human 5-HT2C Receptor: 5.73 (pKi)
storage
Desiccate at RT
5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32293 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38669 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
| Chembest Research Laboratories Limited | +86-21-20908456 | sales@BioChemBest.com | China | 6005 | 61 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10266 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
View Lastest Price from 5-Chloro-N-[4-methoxy-3-(1-piperazinyl)phenyl]-3-methylbenzo[b]thiophene-2-sulfonamide hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | SB 271046 hydrochloride
209481-24-3
|
US $32.00-133.00 / mg | 99.57% | 10g | TargetMol Chemicals Inc. |
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- SB 271046 hydrochloride
209481-24-3
- US $32.00-133.00 / mg
- 99.57%
- TargetMol Chemicals Inc.