WP1066
- CAS No.
- 857064-38-1
- Chemical Name:
- WP1066
- Synonyms
- WP1066;CS-604;WP1066, >=99%;WP1066/WP-1066;WP1066 USP/EP/BP;STAT Inhibitor III;WP1066 (DMSO solution);WP1066; WP 1066;WP-1066;wp1066(STAT Inhibitor III);Stat3 Inhibitor III, WP1066
- CBNumber:
- CB82616030
- Molecular Formula:
- C17H14BrN3O
- Molecular Weight:
- 356.22
- MDL Number:
- MFCD12912450
- MOL File:
- 857064-38-1.mol
- MSDS File:
- SDS
Melting point | 90-93oC |
---|---|
Boiling point | 569.9±50.0 °C(Predicted) |
Density | 1.425 |
storage temp. | +2C to +8C |
solubility | Soluble in DMSO (up to at least 25 mg/ml) |
form | Off-white solid |
pka | 11.00±0.46(Predicted) |
color | White |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
FDA UNII | 63V8AIE65T |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
HS Code | 29333990 | |||||||||
NFPA 704 |
|
WP1066 price More Price(33)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | 573097 | STAT3 Inhibitor III, WP1066, CAS 857064-38-1, is a cell-permeable AG490 tyrphostin analog that acts as a STAT3 pathway inhibitor. A potent anti-tumor agent. | 857064-38-1 | 10mg | $216 | 2024-03-01 | Buy |
Cayman Chemical | 14736 | WP1066 ≥95% | 857064-38-1 | 1mg | $32 | 2024-03-01 | Buy |
Cayman Chemical | 14736 | WP1066 ≥95% | 857064-38-1 | 5mg | $78 | 2024-03-01 | Buy |
Cayman Chemical | 14736 | WP1066 ≥95% | 857064-38-1 | 10mg | $109 | 2024-03-01 | Buy |
Cayman Chemical | 14736 | WP1066 ≥95% | 857064-38-1 | 25mg | $220 | 2024-03-01 | Buy |
WP1066 Chemical Properties,Uses,Production
Description
WP1066 is a cell-
Uses
WP1066 is a cell-permeable inhibitor of STAT3 that directs dephosphorylation and nuclear export of constitutively phosphorylated STAT3 in U87-MG and U373-MG malignant glioma cells.
target
JAK2
References
1) Kong?et al.?(2005),?Discovery of WP1066, a novel Stat3/c-myc inhibitor with potent antitumor activity against human melanoma in vitro and in vivo;?Cancer Res.?65?1387 2) Iwamaru?et al.?(2007),?A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both invitro and in vivo;?Oncogene?26?2435 3) Ferraioli?et al.?(2007),?WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in acute Myelogenous Leukemia Cells;?Cancer Res.?67?11291 4) Kong,?et al.?(2008),?A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells;?Clin. Cancer Res.?14?5759 5) Kong,?et al.?(2009),?A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells;?Cancer Immunol. Immunother.?58?1023 6) Ma,?et al.?(2017),?Stat3 inhibitor abrogates the expression of PD-1 ligands on Lymphoma cell lines;?J. Clin. Exp. Hematop.?57?21
WP1066 Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32835 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29899 | 58 |
Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39916 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 23430 | 58 |
Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9923 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
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