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4-Chloro-3-(trifluoromethyl)phenyl isocyanate

4-Chloro-3-(trifluoromethyl)phenyl isocyanate Structure
4-Chloro-3-(trifluoromethyl)phenyl isocyanate structure
CAS No.
327-78-6
Chemical Name:
4-Chloro-3-(trifluoromethyl)phenyl isocyanate
Synonyms
1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene;JC0002;Sorafenib INT1;Regorafenib Impurity 61;Sorafenib intermediate 3;Sorafenib related compound 36;2-nitro-4-chlorophenylaceticacid;4-Chloro-3-(trifluoromethyl)benzene;4-chloro-a,a,a-trifluoro-M-tolyl ester;4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate
CBNumber:
CB8262374
Molecular Formula:
C8H3ClF3NO
Molecular Weight:
221.56
MDL Number:
MFCD00013874
MOL File:
327-78-6.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-11-04 16:50:45
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4-Chloro-3-(trifluoromethyl)phenyl isocyanate Properties

Melting point 40-42 °C(lit.)
Boiling point 86-90 °C14 mm Hg(lit.)
Density 1.4720 (estimate)
vapor pressure 91Pa at 20℃
Flash point 211 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility soluble in Chloroform, Methanol
form Low Melting Solid, Powder or Chunks
color White to yellow
Sensitive Moisture Sensitive
BRN 522032
InChI InChI=1S/C8H3ClF3NO/c9-7-2-1-5(13-4-14)3-6(7)8(10,11)12/h1-3H
InChIKey AHFPRSSHNSGRCU-UHFFFAOYSA-N
SMILES C1(Cl)=CC=C(N=C=O)C=C1C(F)(F)F
CAS DataBase Reference 327-78-6(CAS DataBase Reference)
FDA UNII 6TE36JKP7L
Comptox DTXSID DTXSID70369818
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)Health Hazard (GHS08)
GHS05,GHS07,GHS08
Signal word  Danger
Hazard statements  H302+H312+H332-H315-H317-H318-H334-H335
Precautionary statements  P261-P264-P280-P301+P312-P302+P352+P312-P305+P351+P338
target organs Respiratory system
PPE dust mask type N95 (US), Eyeshields, Gloves
Hazard Codes  Xn
Risk Statements  20/21/22-36/37-36/37/38-42-20/22
Safety Statements  7-26-27-37/39-36/37/39-45-23
RIDADR  UN 2206 6.1/PG 3
WGK Germany  3
Hazard Note  Harmful/Moisture Sensitive
HazardClass  6.1
PackingGroup  III
HS Code  29291090
Storage Class 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications Acute Tox. 4 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Eye Dam. 1
Resp. Sens. 1
Skin Irrit. 2
Skin Sens. 1
STOT SE 3
REACH Registrations Active
NFPA 704
1
4 1

4-Chloro-3-(trifluoromethyl)phenyl isocyanate price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 374881 4-Chloro-3-(trifluoromethyl)phenyl isocyanate 98% 327-78-6 5g $30.9 2026-04-30 Buy
TCI Chemical C2778 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >98.0%(GC) 327-78-6 5g $56 2026-04-30 Buy
TCI Chemical C2778 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate >98.0%(GC) 327-78-6 25g $178 2026-04-30 Buy
Usbiological 267374 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Asreported 327-78-6 5g $365 2026-06-03 Buy
Usbiological 267374 4-Chloro-3-(trifluoromethyl)phenyl isocyanate Asreported 327-78-6 10g $505 2026-06-03 Buy
Product number Packaging Price Buy
374881 5g $30.9 Buy
C2778 5g $56 Buy
C2778 25g $178 Buy
267374 5g $365 Buy
267374 10g $505 Buy

4-Chloro-3-(trifluoromethyl)phenyl isocyanate Chemical Properties, Uses, Production

Chemical Properties

White solid or melt

Uses

4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of:

  • N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea
  • [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea]
  • trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea

Uses

4-Chloro-3-(trifluoromethyl)phenyl isocyanate may be used in the synthesis of: N-(5′-deoxy-3′-O-tert-butyldimethylsilyl-β-D-thymidin-5′-yl)-N′-(4-chloro-3-trifluoromethylphenyl)-thiourea [1,3-bis(4-chloro-α,α,α-trifluoro-m-tolyl)urea] trans-1-(4-chloro-3-trifluoromethyl-phenyl)-3-(4-hydroxy-cyclohexyl)-urea

General Description

4-Chloro-3-(trifluoromethyl)phenyl isocyanate participates in an efficient methodology for the synthesis of 5-methyl-3-aryl-2-thiooxazolidin-4-ones.

Flammability and Explosibility

Non flammable

4-Chloro-3-(trifluoromethyl)phenyl isocyanate synthesis

32315-10-9
320-51-4
327-78-6
Synthesis of 4-Chloro-3-(trifluoromethyl)phenyl isocyanate from Triphosgene and 4-Chloro-3-(trifluoromethyl)aniline

4-Chloro-3-(trifluoromethyl)phenyl isocyanate Preparation Products And Raw materials

Raw materials

2-Chloro-5-nitrobenzotrifluoride 4-Chloro-3-(trifluoromethyl)aniline 2-Chlorobenzotrifluoride

Preparation Products

Regorafenib iMpurity Regorafenib Sorafenib

4-Chloro-3-(trifluoromethyl)phenyl isocyanate Suppliers

Global Suppliers ( 501)
Supplier Tel Email Country ProdList Advantage
shandong XuanHong Pharmaceutical Technology Co.,Ltd +86-0531-88801869 15090917080 2955128025@qq.com China 295 55
ELION INTERNATIONAL(HONGKONG) CO., LTD 0571-85381529,0571-85381539; 15967138206 sales@hzbrown.com China 77 62
Beijing Jianuode Pharmaceutical Technology Co., Ltd. 010-67267894 18611880885 gianord@163.com China 33 58
Shandong Jincheng Pharmaceutical Group Co.,Ltd. 0533-5439427 13964385406; henry.zhang@jinchengpharm.com China 44 58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 022-60189726 18812034280 188120342808@163.com China 144 61
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Energy Chemical 400-0056266 sales8178@energy-chemical.com China 44567 61
Supplier Advantage
shandong XuanHong Pharmaceutical Technology Co.,Ltd 55
ELION INTERNATIONAL(HONGKONG) CO., LTD 62
Beijing Jianuode Pharmaceutical Technology Co., Ltd. 58
Shandong Jincheng Pharmaceutical Group Co.,Ltd. 58
TIANJIN PHARMACN MEDICAL TECHNOLOGY CO.,LTD. 61
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Alfa Aesar 84
TCI (Shanghai) Development Co., Ltd. 81
Energy Chemical 61

View Latest Price from 4-Chloro-3-(trifluoromethyl)phenyl isocyanate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4-Chloro-3-(trifluoromethyl)phenyl isocyanate pictures 2026-11-06 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
 1kg 99%min 100kg WUHAN FORTUNA CHEMICAL CO., LTD
4-Chloro-3-(trifluoromethyl)phenyl isocyanate pictures 2026-09-02 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
 $6.00 1KG 99% Henan Fengda Chemical Co., Ltd
4-Chloro-3-(trifluoromethyl)phenyl isocyanate pictures 2026-08-20 4-Chloro-3-(trifluoromethyl)phenyl isocyanate
327-78-6
 $1.10 1g 99.9% 100 Tons Min Dideu Industries Group Limited

4-Chloro-3-(trifluoromethyl)phenyl isocyanate Spectrum

4-Chloro-3-(trifluoromethyl)phenyl isocyanate(327-78-6)1HNMR4-Chloro-3-(trifluoromethyl)phenyl isocyanate(327-78-6)Raman4-Chloro-3-(trifluoromethyl)phenyl isocyanate(327-78-6)IR

327-78-6 (4-Chloro-3-(trifluoromethyl)phenyl isocyanate) Related Search:

Propyl isocyanate 4-Chlorobenzotrifluoride 4-(Chloromethyl)benzoic acid 3-Fluorobenzotrifluoride Vinylbenzyl chloride
Phenyl butyrate Chlorosulfonyl isocyanate Diphenyl chlorophosphate Phenyl isothiocyanate 2-Methylbenzotrifluoride
Phenyl chloroformate Phenylhydrazine Trityl olmesartan Benzotrifluoride Phenyl valerate
Phenyl acetate 4-Chloro-3-(trifluoromethyl)aniline Epichlorohydrin

1of4

4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE 3-TRIFLUOROMETHYL-4-CHLORO-PHENYL ISOCYANATE 4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL ISOCYANATE 98% 4-Chloro-α,α,α-trifluoro-m-tolyl isocyanate 4-Chloro-3-(trifluoromethyl)phenyl isocyanate,98% 4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 98% 5GR Benzene, 1-chloro-4-isocyanato-2-(trifluoromethyl)- 4-chloro-a,a,a-trifluoro-M-tolyl ester 4-Chloro-3-(trifluoroMethyl)phenyl isocyanate, 97.5% 4-Chloro-3-(trifluoroMethoxy)phenyl Isocyanate Three fluorine chlorine - 4-3 - Methyl phenyl isocyanate Sorafenib INT1 Isocyanic Acid 4-Chloro-3-(trifluoromethyl)phenyl Ester 4-CHLORO-3-TRIFLUROMETHYL)PHENYL ISOCYANATE 4-Chloro-3-(trifluoromethyl)phenyl isocyanate(327-78-6) 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate > 4-Chloro-3-(trifluoromethy) phenyl isocyanate Phenyl 4- chloro -3- trifluoromethyl isocyanate Sorafenib intermediate 3 2-nitro-4-chlorophenylaceticacid JC0002 Regorafenib Impurity 61 4-Chloro-3-(trifluoromethyl)benzene Sorafenib related compound 36 1-Chloro-4-isocyanato-2-(trifluoromethyl)benzene 327-78-6 372-78-6 327-18-6 ClC6H3CF3NCO ARYL ISOCYANATE Building Blocks Organic Building Blocks Nitrogen Compounds Isocyanates Phenyl isocyanate&Phenyl isothiocyanate Isocyanates Nitrogen Compounds Organic Building Blocks