BIX02189
- CAS No.
- 1265916-41-3
- Chemical Name:
- BIX02189
- Synonyms
- BIX02189（d）;BIX02189 (BIX 02189);(Z)-3-((3-((Dimethylamino)methyl)phenylamino)(phenyl)methylene)-N,N-dimethyl-2-oxoindoline-6-c;(3Z)-3-[[[3-[(Dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide;1H-Indole-6-carboxamide, 3-[[[3-[(dimethylamino)methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo-, (3Z)-;Mitogen-activated protein kinase kinase,inhibit,MAP2K,MAPKK,MEK,BIX02189,Extracellular signal regulated kinases,Inhibitor,ERK,BIX-02189
- CBNumber:
- CB82624099
- Molecular Formula:
- C27H28N4O2
- Molecular Weight:
- 440.54
- MDL Number:
- MFCD18074528
- MOL File:
- 1265916-41-3.mol
| Boiling point | 653.4±55.0 °C(Predicted) |
|---|---|
| Density | 1.230±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility |
DMSO:34.48(Max Conc. mg/mL);78.27(Max Conc. mM) DMF:15.0(Max Conc. mg/mL);34.05(Max Conc. mM) DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.13(Max Conc. mM) Ethanol:10.0(Max Conc. mg/mL);22.7(Max Conc. mM) |
| form | A crystalline solid |
| pka | 11.61±0.20(Predicted) |
| color | White to yellow |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS02 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315+H320-H335-H336-H226 |
| Precautionary statements | P501-P261-P270-P240-P210-P233-P243-P241-P242-P271-P264-P280-P370+P378-P337+P313-P305+P351+P338-P362+P364-P303+P361+P353-P332+P313-P301+P312+P330-P304+P340+P312-P403+P233-P403+P235-P405 |
| HS Code | 2933790090 |
BIX02189 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 16999 | BIX02189 ≥98% | 1265916-41-3 | 5mg | $117 | 2024-03-01 | Buy |
| Cayman Chemical | 16999 | BIX02189 ≥98% | 1265916-41-3 | 10mg | $210 | 2024-03-01 | Buy |
| Cayman Chemical | 16999 | BIX02189 ≥98% | 1265916-41-3 | 25mg | $290 | 2024-03-01 | Buy |
| Cayman Chemical | 16999 | BIX02189 ≥98% | 1265916-41-3 | 50mg | $760 | 2021-12-16 | Buy |
| TRC | B591765 | BIX02189 | 1265916-41-3 | 10mg | $250 | 2021-12-16 | Buy |
BIX02189 Chemical Properties,Uses,Production
Uses
BIX 02189 inhibits TGF-b1-induced lung cancer cell metastasis by directly targeting TGF-b type I receptor.
Definition
ChEBI: 3-[[3-[(dimethylamino)methyl]anilino]-phenylmethylidene]-N,N-dimethyl-2-oxo-1H-indole-6-carboxamide is an indolecarboxamide.
Enzyme inhibitor
This selective MEK/ERK pathway inhibitor (FW = 440.54 g/mol; CAS 1265916-41-3; Solubility: 100 mM in DMSO; 100 mM for monohydrochloride salt), also named (3Z)-3-[[[3-[(dimethylamino) methyl]phenyl]amino]phenylmethylene]-2,3-dihydro-N,N-dimethyl-2-oxo- 1H-indole-6-carboxamide, targets Mitogen/Extracellular signal-regulated Kinase-5, or MEK5 (IC50 = 1.5 nM), and Extracellular-signal-Regulated Kinase, or ERK5 (IC50 = 59 nM), showing far weaker effects on MEK1 (IC50 = 6200 nM), MEK2 (IC50 = >6200 nM), ERK1 (IC50 >6200 nM), JNK2 (IC50 >6200 nM), TGFβR1 (IC50 = 580 nM), EGFR (IC50 >6300 nM), and STK16 (IC50 >6300 nM). Pharmacology: ERK5 is an atypical MAPK that is activated in the heart by pressure overload. ERK5 regulates cardiac hypertrophy and hypertrophy-induced apoptosis, and silencing ERK5 expression or inhibiting its kinase activity with BIX02189 reduces Myocyte Enhancer Factor-2 (MEF2) transcriptional activity and blunted hypertrophic responses in neonatal rat cardiomyocytes, or NRCMs. By applying BIX02189 to NRCMs, ERK5 phosphorylation is blocked without affecting other MAP kinases. BIX02189 induces apoptosis in acute myeloid leukemia tumor cells without affecting T cells from healthy donors
storage
Store at -20°C
BIX02189 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30250 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 |