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GLI1-Mediated transcription inhibitor

GLI1-Mediated transcription inhibitor structure

CAS No.: 496794-70-8

Chemical Name:: GLI1-Mediated transcription inhibitor

Synonyms: 104683;HhAntag;GLI1-Mediated transcription inhibitor;HhAntag,Smoothened,Smo,Inhibitor,inhibit;N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3;N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;N-[4-Chloro-3-[5-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide;BenzaMide, N-[4-chloro-3-[6-(diMethylaMino)-1H-benziMidazol-2-yl]phenyl]-3,5-diMethoxy-;N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide;N-(4-chloro-3-(5-(diMethylaMino)-1H-benzo[d]iMidazol-2-yl)phenyl)-3,5-diMethoxybenzaMide

CBNumber:: CB82627904

Molecular Formula:: C24H23ClN4O3

Molecular Weight:: 450.92

MDL Number:: MFCD25976715

MOL File:: 496794-70-8.mol

Last updated:2024-07-02 08:55:20

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GLI1-Mediated transcription inhibitor Properties

Density	1.337±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	insoluble in H2O; ≥13.3 mg/mL in DMSO; ≥52.3 mg/mL in EtOH with gentle warming
form	solid
pka	10.34±0.10(Predicted)
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302

Precautionary statements

P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

GLI1-Mediated transcription inhibitor price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	28296	HhAntag	496794-70-8	5mg	$116	2024-03-01	Buy
Cayman Chemical	28296	HhAntag	496794-70-8	25mg	$456	2024-03-01	Buy
Cayman Chemical	28296	HhAntag	496794-70-8	1mg	$32	2024-03-01	Buy
Cayman Chemical	28296	HhAntag	496794-70-8	10mg	$214	2024-03-01	Buy
ChemScene	CS-1233	HhAntag 98.70%	496794-70-8	5mg	$295	2021-12-16	Buy

Product number	Packaging	Price	Buy
28296	5mg	$116	Buy
28296	25mg	$456	Buy
28296	1mg	$32	Buy
28296	10mg	$214	Buy
CS-1233	5mg	$295	Buy

GLI1-Mediated transcription inhibitor Chemical Properties,Uses,Production

Biological Activity

hhantag is a hedgehog signaling antagonist. ligand-dependent activation of the hedgehog (hh) signaling pathway has been associated with tumorigenesis in a number of human tissues.

in vitro

hhantag has been evaluated for its effect on hh pathway across a large panel of cancer cell lines. hhantag demonstrated to be around 10-times more potent than cyclopamine at inhibiting the activity of hh pathway. a range of cellular sensitivities to hhantag was observed with ic50 values for growth inhibition ranging from ~2 μm to >30 μm. in contrast to previous reports, no tissue specificity of in vitro sensitivity to hhantag was observed [1].

in vivo

oral administration of hhantag to mice with primary human xenografts resulted in significant growth delay in both pancreatic and colon adenocarcinoma models, with average tumour growth inhibitions of 29% and 48%, respectively. moreover, the hhantag doses required to inhibit the tumor growth were similar to the doses required to fully inhibit endogenous hh target genes in tumour stroma or in surrogate normal tissues, indicating that such growth inhibition was a specific consequence of hh inhibition [1].

IC 50

from ~2 μm to >30 μm

References

[1] yauch rl,gould se,scales sj,tang t,tian h,ahn cp,marshall d,fu l,januario t,kallop d,nannini-pepe m,kotkow k,marsters jc,rubin ll,de sauvage fj. a paracrine requirement for hedgehog signalling in cancer. nature.2008 sep 18;455(7211):406-10.

GLI1-Mediated transcription inhibitor Preparation Products And Raw materials

Raw materials

Preparation Products

GLI1-Mediated transcription inhibitor Suppliers

Global( 55)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29826	58
Coresyn Pharmatech Co., Ltd.	+86-571-86626709 +86-18157142896	cbc@coresyn.com	China	9991	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8474	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
ChemShuttle, Inc.	0510-83588313-802 18800520310;	sales@chemshuttle.com	China	2993	62
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4863	58

Supplier	Advantage
career henan chemical co	58
Coresyn Pharmatech Co., Ltd.	58
TargetMol Chemicals Inc.	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
ChemShuttle, Inc.	62
Haoyuan Chemexpress Co., Ltd.	61
MedChemexpress LLC	58

View Lastest Price from GLI1-Mediated transcription inhibitor manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2020-01-02	N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide 496794-70-8	US $1.00 / KG	1KG	Min98% HPLC	g/kg/ton	Career Henan Chemical Co

N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide
496794-70-8
US $1.00 / KG
Min98% HPLC
Career Henan Chemical Co

GLI1-Mediated transcription inhibitor Spectrum

GLI1-Mediated transcription inhibitor(496794-70-8)MS

496794-70-8(GLI1-Mediated transcription inhibitor)Related Search:

N-(4-chloro-3-(5-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide hydrochloride

GLI1-Mediated transcription inhibitor BenzaMide, N-[4-chloro-3-[6-(diMethylaMino)-1H-benziMidazol-2-yl]phenyl]-3,5-diMethoxy- HhAntag N-(4-chloro-3-(5-(diMethylaMino)-1H-benzo[d]iMidazol-2-yl)phenyl)-3,5-diMethoxybenzaMide N-[4-Chloro-3-[5-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide N-(4-Chloro-3-(6-(dimethylamino)-1H-benzo[d]imidazol-2-yl)phenyl)-3,5-dimethoxybenzamide N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3 104683 N-[4-chloro-3-[6-(dimethylamino)-1H-benzimidazol-2-yl]phenyl]-3,5-dimethoxybenzamide HhAntag,Smoothened,Smo,Inhibitor,inhibit 496794-70-8