ChemicalBook >> CAS DataBase List >>(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one structure

CAS No.: 39777-61-2

Chemical Name:: (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one

Synonyms: RPN77612;TFEB activator 1;Curcumin analog C1;Curcumin analog compound C1;TFEB activator 1, 10 mM in DMSO;Curcumin analog C1(TFEB activator 1 );(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1;1,5-Bis-(2-methoxy-phenyl)-penta-1,4-dien-3-one;(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one;(1E,4E)-1,5-Bis(2-methoxyphenyl)-1,4-pentadien-3-one

CBNumber:: CB82631480

Molecular Formula:: C19H18O3

Molecular Weight:: 294.34

MDL Number:: MFCD00719180

MOL File:: 39777-61-2.mol

MSDS File:: SDS

Last updated:2025-04-18 09:52:57

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(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Properties

Melting point	120-122 °C(Solv: ethanol (64-17-5); water (7732-18-5))
Boiling point	467.2±40.0 °C(Predicted)
Density	1.128±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 125 mg/mL (424.68 mM)
form	A solid
color	Light yellow to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H319-H315-H335

Precautionary statements

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501

NFPA 704

	0
2		0

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
AK Scientific	X5503	(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one	39777-61-2	50mg	$196	2021-12-16	Buy
CSNpharm	CSN25353	TFEBactivator1	39777-61-2	100mg	$300	2021-12-16	Buy
Ambeed	A370554	(1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one 95%	39777-61-2	250mg	$346	2021-12-16	Buy
DC Chemicals	013005	CurcuminanalogC1(TFEBactivator1)	39777-61-2	002	$800	2021-12-16	Buy
Ambeed	A370554	(1E,4E)-1,5-Bis(2-methoxyphenyl)penta-1,4-dien-3-one 95%	39777-61-2	1g	$906	2021-12-16	Buy

Product number	Packaging	Price	Buy
X5503	50mg	$196	Buy
CSN25353	100mg	$300	Buy
A370554	250mg	$346	Buy
013005	002	$800	Buy
A370554	1g	$906	Buy

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Chemical Properties,Uses,Production

Uses

TFEB activator 1 is an orally effective, mTOR-independent activator of TFEB. TFEB activator 1 significantly promotes the nuclear translocation of Flag-TFEB with an EC50 of 2167 nM. TFEB activator 1 enhances autophagy without inhibiting the mTOR pathway and has the potential for neurodegenerative diseases treatment[1].

in vivo

The medium lethal dose (LD₅₀) value of TFEB activator 1 (Compound C1) is 175 mg/kg in the acute toxicity assay (single-dose i.v. tail vein injection; in rats) ^[1].
? Short-term oral administration of TFEB activator 1 (low dosage 10 mg/kg and high dosage 25 mg/kg; for 24 h) dose-dependently increases the expression of LC3B-II and TFEB in the liver, frontal cortex and striatum of the brain^[1].
? Chronic administration of TFEB activator 1 (10 mg/kg per day; orally administered by gavage) activates TFEB and enhances autophagy in rat brains^[1].

Animal Model:	Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g^[1]
Dosage:	10 mg/kg and 25 mg/kg
Administration:	Short-term oral administration; for 24 hours
Result:	Activated TFEB and enhanced autophagy and lysosome biogenesis in rat brain.

Animal Model:	Adult male Sprague-Dawley (SD) rats weighing 350 to 400 g^[1]
Dosage:	10 mg/kg
Administration:	Chronic oral administration; daily; for 21 days
Result:	Activated TFEB and enhanced autophagy in rat brains.

References

[1] Song JX, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016 Aug 2;12(8):1372-89. DOI:10.1080/15548627.2016.1179404

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Preparation Products And Raw materials

Raw materials

Preparation Products

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Suppliers

Global( 63)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Shenzhen Excellent Biotech Co., Ltd.	13480692018	ramyan@ex-biotech.com	CHINA	954	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32159	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30231	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23541	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38630	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Alchem Pharmtech,Inc.	58
Shenzhen Excellent Biotech Co., Ltd.	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
ANHUI WITOP BIOTECH CO., LTD	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58

View Lastest Price from (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2024-11-19	TFEB activator 1 39777-61-2	US $35.00-85.00 / mg		99.77%	10g	TargetMol Chemicals Inc.

TFEB activator 1
39777-61-2
US $35.00-85.00 / mg
99.77%
TargetMol Chemicals Inc.

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one Spectrum

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one(39777-61-2)¹HNMR

(1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1,4-dien-3-one 1,4-Pentadien-3-one, 1,5-bis(2-Methoxyphenyl)-, (1E,4E)- Curcumin analog C1 1,5-Bis-(2-methoxy-phenyl)-penta-1,4-dien-3-one TFEB activator 1 (1E,4E)-1,5-Bis(2-Methoxyphenyl)penta-1 Curcumin analog compound C1 RPN77612 (1E,4E)-1,5-Bis(2-methoxyphenyl)-1,4-pentadien-3-one Curcumin analog C1(TFEB activator 1 ) disease,TFEB,Inhibitor,inhibit,mTOR-independent,TFEB activator1,TFEB activator 1,neurodegenerative,orally,Autophagy,effective,TFEB activator-1 TFEB activator 1, 10 mM in DMSO 39777-61-2