Mito-TEMPO
- CAS No.
- 1334850-99-5
- Chemical Name:
- Mito-TEMPO
- Synonyms
- MitoTEMP0;Mito-TEMPO;MitoTEMPO >=98% (HPLC);MitoTEMPO, a mitochondrial targeted antioxidant;(2-(2,2,6,6-Tetramethylpiperidin-1-oxyl-4-ylamino)-2-oxoethyl)triphenylphosphonium chloride;inhibit,Mito-TEMPO,Mitochondrial Metabolism,Reactive Oxygen Species,MitoTEMPO,Mito TEMPO,Inhibitor
- CBNumber:
- CB82645108
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD26406410
- MOL File:
- Mol file
- MSDS File:
- SDS
Mito-TEMPO price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0737 | MitoTEMPO ≥98% (HPLC) | 1334850-99-5 | 5mg | $88.2 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0737 | MitoTEMPO ≥98% (HPLC) | 1334850-99-5 | 25mg | $357 | 2024-03-01 | Buy |
| ChemScene | CS-0067207 | Mito-TEMPO 98.05% | 1334850-99-5 | 50mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-0067207 | Mito-TEMPO 98.05% | 1334850-99-5 | 100mg | $700 | 2021-12-16 | Buy |
| ChemScene | CS-0067207 | Mito-TEMPO 98.05% | 1334850-99-5 | 10mg | $110 | 2021-12-16 | Buy |
Mito-TEMPO Chemical Properties,Uses,Production
Description
Mito-TEMPO (1334850-99-5) is a mitochondria-targeted antioxidant. Partially prevents mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery.1?Resolves mitochondrial oxidative stress and rescues coronary collateral growth in Zucker obese fatty rats.2?Protects mitochondrial membrane potential and attenuates reperfusion-induced ROS production in a mouse ventricular myocyte model.3?Abrogates the induction of senescence in a human vascular smooth muscle cell model.4
Uses
MitoTEMPO has been used as a mitochondria-targeted antioxidant.
Biochem/physiol Actions
MitoTEMPO is a mitochondrially targeted antioxidant, a specific scavenger of mitochondrial superoxide. MitoTEMPO is a combination of the antioxidant piperidine nitroxide TEMPO with the lipophilic cation triphenylphosphonium, giving MitoTEMPO the ability to pass through lipid bilayers with ease and accumulate several hundred-fold in mitochondria. Mitochondrial dysfunction and oxidative stress contribute to a variety of disorders involving cardiovascular, kidney, liver disorders, Parkinson′s and Alzheimer′s disease.
References
1) Liang?et al.?(2010)?SOD1 and MitoTEMPO partially prevent mitochondrial permeability transition pore opening, necrosis and mitochondrial apoptosis after ATP depletion recovery; Free Radic. Biol. Med.?49?1550 2) Pung?et al.?(2012)?Resolution of mitochondrial oxidative stress rescues coronary collateral growth in Zucker obese fatty rats; Arterioscler. Thromb. Vasc. Biol.?32?325 3) DeSantiago?et al.?(2013)?Ischemia/Reperfusion injury protection by mesenchymal stem cell derived antioxidant capacity; Stem Cells Dev.?22?2497 4) Mistri?et al.?(2013)?A role for mitochondrial oxidants in stress-induced premature senescence of human vascular smooth muscle cells; Redox. Biol.?1?411
Mito-TEMPO Preparation Products And Raw materials
Raw materials
Preparation Products
Mito-TEMPO Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32165 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | meilunui@163.com | China | 4727 | 58 |
| Shanghai Qianhao Biotechnology Co., LTD | 13524877553 | 13524877553@163.com | China | 32 | 58 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4861 | 58 |
| ShangHai Caerulum Pharma Discovery Co., Ltd. | 18149758185 18149758185 | sales-cpd@caerulumpharma.com | China | 3466 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4512 | 55 |