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LY 2606368

CAS No.
1234015-52-1
Chemical Name:
LY 2606368
Synonyms
CS-1453;LY 2606368;Prexasertib;Prexasertib free base;Prexasertib (LY2606368);LY 2606368;LY-2606368;PREXASERTIB;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile;5-[[5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile;2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-;5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile LY2606368
CBNumber:
CB82667926
Molecular Formula:
C18H19N7O2
Molecular Weight:
365.39
MDL Number:
MFCD25977016
MOL File:
1234015-52-1.mol
MSDS File:
SDS
Last updated:2024-07-02 08:55:20

LY 2606368 Properties

Boiling point 608.5±55.0 °C(Predicted)
Density 1.37±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in DMSO
form A crystalline solid
pka 11.89±0.10(Predicted)
color Light yellow to brown
FDA UNII 820NH671E6
NCI Drug Dictionary prexasertib

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

LY 2606368 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 21490 LY2606368 ≥98% 1234015-52-1 1mg $116 2024-03-01 Buy
Cayman Chemical 21490 LY2606368 ≥98% 1234015-52-1 5mg $486 2024-03-01 Buy
Cayman Chemical 21490 LY2606368 ≥98% 1234015-52-1 10mg $799 2024-03-01 Buy
Cayman Chemical 21490 LY2606368 ≥98% 1234015-52-1 25mg $1141 2024-03-01 Buy
Usbiological 454002 LY 2606368 1234015-52-1 500ug $566 2021-12-16 Buy
Product number Packaging Price Buy
21490 1mg $116 Buy
21490 5mg $486 Buy
21490 10mg $799 Buy
21490 25mg $1141 Buy
454002 500ug $566 Buy

LY 2606368 Chemical Properties,Uses,Production

Description

LY2606368 is a checkpoint kinase 1 (Chk1) inhibitor with a Ki value of 0.9 nM against the purified target and IC50 values of <13 nM in a viability study of multiple colorectal cancer cell lines. Inhibition of Chk1 causes double-strand DNA breakage in cells leading to an excessive cell damage burden and subsequent cell death. In vitro, LY2606368 inhibits the doxorubicin-activated G2/M checkpoint in p53-deficient HeLa cells with an EC50 value of 9 nM. LY2606368, at 25 nM, also significantly induces apoptosis and inhibits colony formation in AGS and MKN1 gastric cancer cells.

Uses

LY 2606368 is a novel CHK1 inhibitor under investigation as a chemopotentiating agent. It causes double-stranded DNA breakage while simultaneously removing the protection of the DNA damage checkpoints. LY 2606368 is representative of a novel class of drugs for the treatment of cancer and tumor growth inhibition.

References

[1] wu w, bi c, bence a k, et al. antitumor activity of chk1 inhibitor ly2606368 as a single agent in sw1990 human pancreas orthotopic tumor model. cancer research, 2012, 72(8 supplement): 1776.
[2] lainchbury m, matthews t p, mchardy t, et al. discovery of 3-alkoxyamino-5-(pyridin-2-ylamino) pyrazine-2-carbonitriles as selective, orally bioavailable chk1 inhibitors. journal of medicinal chemistry, 2012, 55(22): 10229-10240.
[3] mcneely s c, burke t f, durlandbusbice s, et al. abstract a108: ly2606368, a second generation chk1 inhibitor, inhibits growth of ovarian carcinoma xenografts either as monotherapy or in combination with standard-of-care agents. molecular cancer therapeutics, 2011, 10(supplement 1): a108.

LY 2606368 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 2606368 Spectrum

LY 2606368 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile LY2606368 5-[[5-[2-(3-Aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]-2-pyrazinecarbonitrile 5-((5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-yl)amino)pyrazine-2-carbonitrile Prexasertib LY 2606368;LY-2606368;PREXASERTIB Prexasertib (LY2606368) CS-1453 2-Pyrazinecarbonitrile, 5-[[5-[2-(3-aminopropoxy)-6-methoxyphenyl]-1H-pyrazol-3-yl]amino]- Prexasertib free base SIK,Prexasertib,LY 2606368,Checkpoint Kinase (Chk),HT-29,S296,Apoptosis,DNA,double-stranded,inhibit,autophosphorylation,H2AX,ATP-competitive,HeLa,MELK,RSK1,CDK2,LY-2606368,Inhibitor,S516,ARK5,replication,BRSK2,CDC25A 1234015-52-1 C18H19N7O2