GDC-0834
- CAS No.
- 1133432-50-4
- Chemical Name:
- GDC-0834
- Synonyms
- GDC-0834 (S-enantiomer);GDC 0834 S enantiomer,GDC0834 Senantiomer;Benzo[b]thiophene-2-carboxamide, N-[3-[6-[[4-[(2S)-1,4-dimethyl-3-oxo-2-piperazinyl]phenyl]amino]-4,5-dihydro-4-methyl-5-oxo-2-pyrazinyl]-2-methylphenyl]-4,5,6,7-tetrahydro-
- CBNumber:
- CB82677398
- Molecular Formula:
- C33H36N6O3S
- Molecular Weight:
- 596.74
- MDL Number:
- MFCD26142642
- MOL File:
- 1133432-50-4.mol
GDC-0834 price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6128 | GDC-0834S-enantiomer 95.11% | 1133432-50-4 | 2mg | $264 | 2021-12-16 | Buy |
| ChemScene | CS-6128 | GDC-0834S-enantiomer 95.11% | 1133432-50-4 | 5mg | $420 | 2021-12-16 | Buy |
| ChemScene | CS-6128 | GDC-0834S-enantiomer 95.11% | 1133432-50-4 | 10mg | $600 | 2021-12-16 | Buy |
| Crysdot | CD11348722 | GDC-0834S-Enantiomer 95+% | 1133432-50-4 | 50mg | $508 | 2021-12-16 | Buy |
| Crysdot | CD11348722 | GDC-0834S-Enantiomer 95+% | 1133432-50-4 | 5mg | $133 | 2021-12-16 | Buy |
GDC-0834 Chemical Properties,Uses,Production
Biological Activity
GDC-0834 is a potent and selective Bruton's tyrosine kinase (Btk) inhibitor, The IC50 values in biochemical and cellular assays is 5.9 and 6.4 nM. The in vivo IC50 values in mouse and rat are 1.1 and 5.6 μM, respectively. B cell antigen receptor (BCR) stimulation phosphorylated and activated Btk. Btk gene defects result in a disease named as X-linked agammaglobulinemia which profoundly decreased mature B cells due to a block in B cell development.
in vivo
In a rat collagen-induced arthritis (CIA) model, administration of GDC-0834 (30-100 mg/kg) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology.In PXB chimeric mice with humanized liver, GDC-0834 exhibited low clearance. in most samples from the cohorts dosed orally at 35 and 105 mg GDC-0834, plasma concentrations of GDC-0834 in humans were below the limit of quantitation (<1 ng/ml). High interest in a BTK inhibitor for clinical evaluation and uncertainty in human pharmacokinetic prediction prompted an investigational new drug strategy, in which GDC-0834 was rapidly advanced to a single-dose human clinical trial.
GDC-0834 Preparation Products And Raw materials
Raw materials
Preparation Products
GDC-0834 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Jinan Trio PharmaTech Co., Ltd. | +86 (531) 88811783 | sales@trio-pharmatech.com (International market) | China | 1856 | 62 |
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24734 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Shanghai Maclean Biochemical Technology Co., LTD | 021-50706066 15221275939 | shenlinxing@macklin.cn | China | 29802 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9268 | 58 |